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Ramanjaneyulu, J.
- A Study on Antidepressant Activity of Medha gulika-a Polyherbal Formulation in Experimental Animal Models
Abstract Views :287 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 2 (2015), Pagination: 115-121Abstract
According to WHO, depression is a common mental disorder, characterized by sadness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness and poor concentration. The objective of the proposed study was to investigate the therapeutic potential of poly herbal formulation Medhagulika on Depression in different animal models. Evaluation of antidepressant activity was done by using 3 doses of Medhagulika (53.85, 102.77 and 154.16mg/kg) in vivo models. Animals treated with all three doses of Medhagulika witnessed a decrease in their immobility times in FST and TST which was significant when compared with control. Similarly, animals treated with imipramine (15mg/kg), as expected showed a significant decrease in the immobility time. In learned Helplessness Test, The Medhagulika treated mices showed significant increase in avoidance response and decreased in escape failure in response to shock treatment. Open field test utilizes behavioural changes in rodent exposed to novel environments and is used to confirm the observed antidepressant effect is not due to stimulation of general motor activity.Keywords
Medhagulika, Forced Swim Test, Tail Suspension Test, Anti Depressant, Open Field Test.- Studies on Memory Enhancing Property of Bravobol-A Polyherbal Formulation in Experimentally Induced Alzheimers Disease in Experimental Animals
Abstract Views :180 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 2 (2015), Pagination: 1-8Abstract
In recent decades, it has become one of the principal pillars of a branch of science called cognitive neuroscience, an interdisciplinary link between cognitive and neuroscience. The objective of this to investigate the neuropsychological effect of a polyherbal formulation Bravobol on learning and memory processes in mice by elevated plus maze and Morris water maze model. Bravobol contains Evolvulus alsinoids (Shankhpushpi), Bacopa monnieri (Brahmi), Withania somnifera (Ashwagandha), Celastrus paniculatus (Malkangani) and Abhrak bhasma. Its effect (250, 500, and 750 mg/kg, p.o.) was tested on learning and memory processes. Activity of Bravobol on acquisition and retention was studied using elevated plus maze model (EPM) and spatial memory using Morris water maze model (MWM) in mice. The results were compared with the vehicle-treated group. Administration of Bravobol (250, 500 and 750 mg/kg, p.o) showed significant reduction in transfer latency in EPM and escape latency in MWM as compared to the control group. Bravobol may act as a memory enhancer formulation and may also be useful as a supportive adjuvant in the treatment of Alzheimers disease.Keywords
Polyherbal Formulation, Elevated Pluz Maze, Moriss Water Maze.- Studies on Memory Enhancing Property of Sumenta-A Polymherbal Formulation in Experimentally Induced Alzhiemers Disease in Experimental Animals
Abstract Views :233 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN
1 Department of Pharmacology, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore, IN