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Pandey, Himanshu
- Antiulcer Potential of Cucumis melo Var. Momordica (Roxb.), Duthie & Fuller Fruits in Experimental Animal
Abstract Views :205 |
PDF Views:73
Authors
Arvind Kumar Srivastava
1,
Alok Mukerjee
1,
P. W. Ramteke
2,
Himanshu Pandey
2,
Shanti Bhushan Mishra
1
Affiliations
1 Department of Pharmaceutical Chemistry, United Institute of Pharmacy, Naini, Allahabad, IN
2 Department of Pharmaceutical Sciences, SHUATS, Allahabad, IN
1 Department of Pharmaceutical Chemistry, United Institute of Pharmacy, Naini, Allahabad, IN
2 Department of Pharmaceutical Sciences, SHUATS, Allahabad, IN
Source
Journal of Pharmaceutical Research, Vol 16, No 3 (2017), Pagination: 218-223Abstract
Purpose: This study was aimed to evaluate the antiulcer potential of Cucumis melo var. momordica (Roxb.) Duthie&Fuller, fruits.
Methodology: Ethanol and pylorus ligation induced ulcer methods were used in rats for the study. The aqueous and ethanolic extracts (200 and 400 mg/kg body weight) were administered orally and effects on volume of gastric secretions, ulcer index, total and free acidity were evaluated.
Findings: A significant dose dependent reduction (P < 0.05) in the acid parameters like ulcer index, gastric volume, free and total acidity and elevation in pH were observed after treatment with 200 and 400 mg/kg extracts in Pylorus ligation and ethanol-induced ulcer models.This reduction in acid-secretary parameters and ulcer score suggesting that acid inhibition accelerates ulcer healing.
Conclusion: Based on our findings, we presume that the anti-secretary properties of both extracts were responsible for its anti-ulcer potency. These findings suggest the potential for use of Cucumis melo extract as an adjuvant in the treatment of gastric ulcer.
Keywords
Antiulcer, Cucumis melo Var. Momordica (Roxb.) Duthie & Fuller, Ethanolic Extract Pylorus Ligation.Full Text
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- Pathophysiology and Management of Diabetes:A Review
Abstract Views :437 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111(C.G.), IN
1 Department of Pharmacology, Columbia Institute of Pharmacy, Tekari, Near Vidhansabha, Raipur- 493111(C.G.), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 4 (2017), Pagination: 219-222Abstract
Diabetes mellitus is a very common metabolic disorder of endocrine system, every year large Number of people suffered from diabetes. According to recent survey in India about 50.8 million people are suffered from diabetes in 2010, and it will rise to 87.0 million till 2030. For the management and prevention of type 1 and type 2 diabetes different approaches have been done throughout the time In this article we have briefly discuss about evaluation of anti-diabetic activity by the use of different in vivo methods including animal model and in vitro method with special reference to cell line techniques. Article also reflect the evaluation of various anti diabetics phytoconstituents which is obtain from different plant source their activity, mechanism of action and it also highlight the advancement that has been done in past few year by different scientist their work title in different beta cell line technique and what output come from their effort to understand diabetes and to overcome it.Keywords
Diabetes Mellitus, Pathophysiology, In-Vivo, In-Vitro Method, Treatment.
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