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Raj, Hasumati
- Development and Validation of Analytical Method for Clopidogrel Bisulphate and Irbesartan by Simultaneous Equation Spectroscopic Method
Abstract Views :184 |
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Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat 394110, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat 394110, IN
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat 394110, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat 394110, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 2 (2016), Pagination: 102-108Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Clopidogrel Bisulphate and Irbesartan in synthetic mixture using simultaneous equation Method. In this spectroscopic method, for Clopidogrel Bisulphate 220.00 nm and 250.00 nm wavelengths were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 10-50 μg/ml at their respective λmax with correlation coefficient (r2) of 0.9996 and 0.9998 for Clopidogrel Bisulphate and Irbesartan, respectively. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (< 2%). The limit of determination was 0.243 μg/ml and 0.323 μg/ml for Clopidogrel Bisulphate and Irbesartan, respectively. The limit of quantification was 0.737 μg/ml and 0.980 μg/ml for Clopidogrel Bisulphate and Irbesartan, respectively. Recovery of Clopidogrel Bisulphate and Irbesartan were found to be 99.57 % and 99.68 % respectively confirming the accuracy of the proposed method. % Assay was found to be 99.41 % and 99.22 % for Clopidogrel Bisulphate and Irbesartan, respectively. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.Keywords
Clopidogrel Bisulphate, Irbesartan, Simultaneous Estimation, Validation Method.- Development and Validation of Analytical Method for Aripiprazole and Escitalopram Oxalate by Simultaneous Equation Spectroscopic Method
Abstract Views :184 |
PDF Views:2
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 1 (2016), Pagination: 41-46Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Aripiprazole and Escitalopram Oxalate in synthetic mixture using simultaneous equation Method. In this spectroscopic method, 255.00 nm and 238.00 nm wavelengths were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 5-30 μg/ml and 15-75 μg/ml at their respective λmax. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.129 and 0.223μg/ml Aripiprazole and Escitalopram Oxalate, respectively. The limit of quantification was 0.392 and 0.677 for Aripiprazole and Escitalopram Oxalate, respectively. Recovery of Aripiprazole and Escitalopram Oxalate in were found to be 100.66 % and 100.70 % respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.Keywords
Aripiprazole, Escitalopram Oxalate, Simultaneous Estimation, Simultaneous Equation Method, Analysis Method.- Candesartan Cilexetil: A Review of Spectroscopic and Chromatographic Method
Abstract Views :184 |
PDF Views:2
Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 1 (2016), Pagination: 53-58Abstract
Candesartan Cilexetil is classified as an AT1 Angiotensin II receptor antagonist as a Antihypertensive agent. There are widely used in treatment of diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and Pharmcodynamic and pharmacokinetic studies as well as stability study. There are many article examines published analytical methods reported so far in the literature for the determination of Candesartan Cilexetil in biological samples and pharmaceutical formulations. These article comprise reviews of analytical methods like Spectrophotometric methods, Chromatographic method including HPLC, HPTLC.Keywords
Candesartan Cilexetil, Spectrophotometry, HPLC, Anti-Hypertensive Agent, AT1 Angiotensin II Receptor Antagonist.- Atorvastatin: A Review on Analytical Method and Its Determination in Pharmaceuticals and Biological Matrix
Abstract Views :220 |
PDF Views:3
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 3 (2015), Pagination: 151-160Abstract
Atorvastatin is the most efficacious of the currently available HMG-CoA Reductase inhibitors used in antilipidemic and also used in athresclerosis, stroke, cardiac risk. The clinical and pharmaceutical analysis of this drug requires effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies as well as stability study. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. This review covers the most recent many analytical methods including spectrophotometric methods, chromatographic method including HPLC, HPTLC and RP HPLC, liquid chromatography tendam mass spectroscopy were reported.Keywords
Atorvastatin, Analytical Method, HPLC, Hmg-Coa Reductase Inhibitors, Antilipidemic.- Simultaneous Estimation of Irbesartan and Atorvastatin by Q Absorption Ratio Method in Their Synthetic Mixture
Abstract Views :218 |
PDF Views:0
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 1 (2015), Pagination: 9-15Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Irbesartan and atorvastatin in synthetic mixture using Q absorption Ratio Method. In this spectroscopic method, 234.7 nm (as an isoabsorptive point) and 226 nm wavelengths (λmax of any of the two drugs) were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 05-30 μg/ml at their respective λmax and at the isoabsorptive point. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.365μg/ml and 0.0622μg/ml for Irbesartan and atorvastatin, respectively. The limit of quantification was 1.108μg/ml and 0.188μg/ml for Irbesartan and atorvastatin, respectively. Recovery of Irbesartan and atorvastatin were found to be 100.51% and 100.16% respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.Keywords
Irbesartan, Atorvastatin, Simultaneous Estimation, Q Absorption Ratio Method, Q Value Analysis Method.- Development and Validation of Stability Indicating Reverse Phase High Performance Liquid Chromatographic Method for Estimation of Donepezil Hcl from Bulk Drug
Abstract Views :180 |
PDF Views:0
Authors
Affiliations
1 Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Shree Dhanvantary Pharmacy College, Kim, Surat, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 2 (2015), Pagination: 96-101Abstract
Stability of Donepezil Hydrochloride(DONE) was investigated using stability indicating Reverse phase high performance liquid chromatography (RP-HPLC) utilizing C-18 column and mobile phase containing Acetonitrile: Water (pH 3.5) in ratio of 40:60 at flow rate of 1 ml min-1. Peaks of donepezil and degradation products were well resolved at retention times < 7 min. Stability was performed in 0.1N hydrochloric acid, 0.1N sodium hydroxide, 3 % hydrogen peroxide, neutral, photolytic and dry heat conditions. Fast hydrolysis was seen in alkaline condition as compared to oxidative and neutral conditions. Methods was validated with respect to linearity, precision, accuracy, specificity and robustness LOQ and LOD. It was also found to be stability indicating, and therefore suitable for the routine analysis of Donepezil hydrochloride in the pharmaceutical formulation.Keywords
Donepezil Hydrochloride, RP- HPLC, Method Development, Stability Studies.- Development and Validation of Stability Indicating High Performance Liquid Chromatographic Method for Indapamide
Abstract Views :182 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
2 Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, IN
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, IN
2 Dharmaj Degree of Pharmacy, Dharmaj, Anand, Gujarat, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 3 (2015), Pagination: 158-164Abstract
An approach of forced degradation study was successfully applied for the development of a stability-indicating high performance liquid chromatographic method for Indapamide in the presence of its degradation products. In the present study a simple, accurate and precise reverse phase liquid chromatographic method has been developed of Olmesartan Indapamide in bulk. Developed Method was achieved on symmetry C18 (150 mm × 4.6 mm, 5 μ) column using a Acetonitrile: 0.02 M Na2HPO4(45:55 v/v) mobile phase and pH 7 adjusted with ortho phosphoric acid. Isocratic elution mode at a flow rate of 1.0 ml/min at Room temperature with a load of 20μl Injection volume. The detection was carried out at 240 nm. The linearity of the proposed method was investigated in the range of 10-50 microg/mL (r2 = 0.998) for Indapamide. The retention time of Indapamide was found to be around 4.79 min and 7.59 min respectively. The drug substances were subjected to stress conditions of acid hydrolysis, base hydrolysis, Oxidative, photolytic and thermal. The developed RP-HPLC method was validated with respect to linearity, accuracy, precision, robustness, LOD and LOQ.Keywords
Indapamide, Hypertension, Stability Study.- Simultaneous Estimation of Irbesartan and Atorvastatin by First Order Derivative Spectroscopic Method in Their Synthetic Mixture Use in Hypertension Condition
Abstract Views :190 |
PDF Views:2
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 1 (2015), Pagination: 1-7Abstract
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of Irbesartan (IRB) and Atorvastatin (ATR) in synthetic mixture. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra was obtained in methanol and the determinations were made at 225.20 nm (ZCP of Atorvastatin) for Irbesartan and 308.15 nm (ZCP of Irbesartan) for Atorvastatin. The linearity was obtained in the concentration range of succinate 5-30 μg/ml for Irbesartan and 5- 30 μg/ml for Atorvastatin Succinate. The mean recovery was 99.25 and 99.65% for Irbesartan and Atorvastatin succinate, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of Irbesartan and Atorvastatin in synthetic mixture. The results of analysis have been validated statistically and by recovery studies. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.Keywords
Irbesartan, Atorvastatin, Simultaneous Estimation,First Order Derivative, Spectroscopy.- Combined Treatment of Aripiprazole and Escitalopram Oxalate Therapy to Treat Major Depressive Disorders
Abstract Views :188 |
PDF Views:2
Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, IN
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 6, No 2 (2016), Pagination: 113-115Abstract
This review article presents the pharmacology of combined treatment of Aripiprazole and Escitalopram oxalate in treatment of Major Depressive Disorders. Aripiprazole is anti psychotic agent. Escitalopram Oxalate is also an antidepressant agent (Selective Serotonin Reuptake Inhibitor). Aripiprazole's antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia. Escitalopram Oxalate is selective serotonin reuptake inhibitors (SSRIs) are a group of chemically diverse antidepressant drugs that specifically inhibit serotonin reuptake. The SSRIs block the reuptake of serotonin, leading to increased concentrations of the neurotransmitter in the synaptic cleft and, ultimately, to greater postsynaptic neuronal activity. The combination of both have decrease dose and improve Depression. Combination of both the drugs were approved by us government and has been used in Major Depressive Disorders. The main objective of this review article is to provide pharmacological information of combined therapy of of Aripiprazole and Escitalopram Oxalate to researcher in development of combined dosage form of this.Keywords
Aripiprazole, Escitalopram Oxalate, Major Depressive Disorders, Pharmacology.- Development and Validation of Analytical Method for Bromhexine Hydrochloride, Chlorpheniramine Maleate and Guaifenesin by Simultaneous Equation Spectroscopic Method
Abstract Views :194 |
PDF Views:0
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 QualityAssurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 QualityAssurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 5, No 2 (2015), Pagination: 69-71Abstract
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Bromhexine hydrochloride, Chlorpheniramine maleate and Guaifenesin in syrup using simultaneous equation Method. In this spectroscopic method, 249.00 nm and 261.00 nm and 274.00 nm wavelengths respectively were selected for measurement of slope and intercept according to its calibration curves. Bromhexine, Chlorpheniramine maleate and Guaifenesin show linearity in a concentration range of 02-10μg/ml, 01-05μg/ml and 25-125μg/ml at their respective λ max. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.102μg/ml, 0.169μg/ml and 0.312μg/ml for Bromhexine, chlorpheniramine maleate and guaifenesin respectively. The limit of quantification was 0.311μg/ml, 0.947μg/ml and 0.514μg/ml for Bromhexine, chlorpheniramine maleate and guaifenesin respectively. Recovery of Bromhexine, guaifenesin and chlorpheniramine maleate were found to be 100.02 %, 101.17 and 100.66% respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.Keywords
Bromhexine Hydrochloride, Guaifenesin, Chlorpheniramine Maleate, Simultaneous Estimation, Simultaneous Equation Method, Analysis Method.- A Review: Determination of Clopidogrel Bisulphate in Biological Fluid and Pharmaceutical Dosage Forms
Abstract Views :266 |
PDF Views:0
Authors
Affiliations
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat-394110, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat-394110, IN
1 Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat-394110, IN
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Kim, Dist: Surat, Gujarat-394110, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 1 (2016), Pagination: 66-70Abstract
Clopidogrel Bisulphate is a mainly use in Anti platelet agent as a ADP receptor blocker and administration of oral tablet dosage form. Chemically, it is Methyl 2-(2- Chlorophenyl) -2-(6, 7-dihydro thieno [3,2-C] Pyridine- 5(4H)-yl) Acetate sulphate. It is used in the treatment of various cardiovascular diseases like Ischemic stroke as well as in Glomerular inflammation, Myocardial infarction, Atherosclerosis disease, Unstable Angina. An extensive survey of the literature published in various analytical and pharmaceutical chemistry related journals has been conducted and the instrumental analytical methods which were developed and used for determination as single or combination with other drugs in bulk drugs, formulations and biological fluids have been reviewed. These reviews of analytical methods including Spectrophotometric methods like Spectrophotometry, Chromatographic method including HPLC, HPTLC were reported.Keywords
Clopidogrel Bisulphate, Analytical Methods, Compendial Method, UV Spectroscopic Method, Chromatographic Methods.- Development and Validation of Analytical Method for Irbesartan and Atorvastatin by Simultaneous Equation Spectroscopic Method
Abstract Views :187 |
PDF Views:0
Authors
Affiliations
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN
1 Gujarat Technological University, Gujarat, IN
2 Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat, IN