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Pathak, Hardik
- Sulodexide in the Diabetic Nephropathy
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Affiliations
1 Intas Pharmaceuticals, 7th floor, Premier House 1, Opp.Gurudwara, SG Highway, Bodakdev, Ahmedabad-382481, IN
2 LTMMC Hospital and Sion Hospital, Mumbai, IN
1 Intas Pharmaceuticals, 7th floor, Premier House 1, Opp.Gurudwara, SG Highway, Bodakdev, Ahmedabad-382481, IN
2 LTMMC Hospital and Sion Hospital, Mumbai, IN
Source
The Indian Practitioner, Vol 66, No 12 (2013), Pagination: 767-770Abstract
No Abstract.- Luliconazole: Paradigm Shift in the Management of Topical Tinea Infections
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Affiliations
1 Dr. Reddy’s Laboratories Ltd, Hyderabad, Telangana, IN
1 Dr. Reddy’s Laboratories Ltd, Hyderabad, Telangana, IN
Source
The Indian Practitioner, Vol 72, No 2 (2019), Pagination: 42-46Abstract
Luliconazole is an imidazole topical antifungal agent with a unique structure. Pre-clinical studies have demonstrated excellent activity against dermatophytes. Although luliconazole belongs to the azole group, it has strong antifungal activities against Trichophyton spp. This may be attributed to a combination of strong in vitro antifungal activity and favourable pharmaco kinetic properties in the skin. Clinical trials have demonstrated its superiority over placebo in dermatophytosis, and performed better than terbinafine. The frequency of application (once daily) and duration of treatment (one week for tinea corporis/cruris and 2 weeks for interdigital tinea pedis) was favourable when compared to other topical regimens in treating tinea pedis. Such regimens include 2–4 weeks of twice-daily treatment with econazole, up to 4 weeks of twice-daily treatment with sertaconazole, 1–2 weeks of twice-daily treatment with terbinafine, 4 weeks of once-daily application of naftifine and 4–6 weeks of once-daily treatment with amorolfine. Luliconazole 1% cream was approved in Japan in 2005 for the treatment of tinea infections. Recently, the US Food and Drug Administration (USFDA) approved luliconazole for interdigital tinea pedis, tinea cruris, and tinea corporis treatment. Topical luliconazole has a favourable safety profile, with mild application-site reactions reported occasionally.Keywords
Luliconazole, Tinea pedis, Tinea corporis, Tinea cruris, once a dailyReferences
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- LUZU label. Prescribing information http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/204153s000lbl.pdf assessed on 30th December, 2018.
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- Gupta AK, Daigle D. A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections. Infection and Drug Resistance 2016; 9: 1–6.
- Feng X et al. Efficacy and tolerability of luliconazole cream 1% for dermatophytoses: A Meta-analysis. Journal of Dermatology 2014; 41: 779–782.
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- Jarratt M et al. Efficacy and safety of once-daily luliconazole 1% cream in patients ≥12 years of age with interdigital tinea pedis: a phase 3, randomized, double-blind, vehicle-controlled study. J Drugs Dermatol. 2014; 13(7):838-46.
- Characterization of 4t Engine Oil Degrading Indigenous Bacteria Isolated from Semi Arid Zone of Rajasthan (Churu)
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Authors
Affiliations
1 Department of Biotechnology, JECRC University, Jaipur Department of Chemistry, JECRC University, Jaipur, Rajasthan,, IN
1 Department of Biotechnology, JECRC University, Jaipur Department of Chemistry, JECRC University, Jaipur, Rajasthan,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 201-205Abstract
The biodegradation potential of petroleum hydrocarbons such as polycyclic aromatic hydrocarbons (PAHs) and n-branched alkanes etc. of 4T engine oil were evaluated in aqueous media using bacterial strain isolated from petroleum contaminated soil of semi Arid region (Churu) of Rajasthan (India). Out of 12 petroleum hydrocarbons degrading bacterial strain one of the most growing bacteria was identified as Achromobacter xylosoxidans M66 by morphological, physiological, biochemical and partial sequencing of 16s rDNA. This strain was capable to degrade 68 ± 2% of n-alkanes, 28 ± 4% PAHs, and the abiotic loss was 20 ± 2% during 28 days incubation period. 64 ± 3% of n-alkanes and 26 ± 3% PAHs were biodegraded and abiotic loss during this period was 21 ± 3% in 35 days of incubation. As expected abiotic losses were decreases with increasing long chain alkanes and PAH’s concentration. Correlation between cell number and biodegradation rate showed that as the number of cell increased the degradation rate is also increased. The hydrocarbon contents were measured by Gas chromatography Mass spectroscopy (GC-MS) QP-2010 plus Shimadzu) carriedColumn-Rtx-5 MS, 30-meter X 0.25 mm i.d. X 0.25 μm film thickness, 1 ml/min; pressure 72.6 kPa and split ratio 10%. The initial temperature was 60ºC kept for 6 minutes and final temperature for 260ºC was kept for 20 minutes with total running time of 50 minutes.Keywords
GC MS, Achromobacter xylosoxidans, n- Alkanes, PAHs, Petroleum hydrocarbonReferences
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- Pandey P, Pathak H and Dave S. Biodegradation of Diesel Oil by Pseudomonas Balearica Strain UKMS3P3 Isolation from Soil around Mathura Refinery. Indian Journal of Environmental Protection. 2018; 8(6): 467-476.
- Bushnell DL and Hass HF. The utilization of certain hydrocarbons by Microorganism. Kansas Agriculture Experiment Station. 1941; 199: 653-673.
- Latha R and Kalaivani R, Bacterial degradation of crude oil by gravimetric analysis. Advances in Applied Science Research. 2012; 3(5): 2789-2795.
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- Jadhav VV et al. Studies on biosurfactant from Oceanobacillus sp. BRI 10 isolated from Antarctic sea water. Desalination. 2013; 318: 64-71.
- Saitou N and Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Molecular biology and evolution. 1987; 4(4): 406-425.
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