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Gourchala Freha ¹, Mihoub Fatma ¹, Derradj Meriem ², Henchiri Cherifa ²

Affiliations
1 Faculty of Natural Sciences and Life, Ibn Khaldoun Tiaret University, DZ
2 Faculties of Sciences, Badji Mokhtar Annaba University, DZ

Abstract

The purpose of our study is to determine the Glycemic Indexes (GIs) of three Algerians varieties of dates in healthy subjects evaluate the satiety and effect on arterial pressure after their consumption. We have first documented the chemical composition of the dates. 10 healthy subjects consumed the dates (carbohydrates content of 50 g) in order to determine the GIs. The responses of glycaemia were monitored during two hours after the dates taking and compared to the reference glucose. In a randomized trial, 20 healthy adults consumed the dates after 12h of fast. We reported the level of satiety on a Visual Analog Scale for 2h further to the ingestion of the dates. Furthermore, 28 normotensives and 45 hypertensive individuals ingested the three varieties in randomized order during 21 days to assess their impact on the Pressure Arterial Systolic (PAS) and Pressure Arterial Diastolic (PAD). We noted significant differences (p<0.05) for the different fractions of sugars, soluble fibers, polyphenols, K⁺, Mg²⁺. The low GIs are denoted among 44.31-52.35, deducting a moderate impact on blood glucose level. The dates reduced hunger and increased satiety. Our varieties studied following their ingestion induced a significant hypotensive activity (p<0.05) on the PAS and, PAD from hypertensive subjects.

Keywords

Algerians Dates, Blood Pressure, Glycemic Index, Humans Subjects, Satiety.

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Gourchala Freha ¹, Mihoub Fatma ¹, Henchiri Cherifa ²

Affiliations
1 Laboratory of Agro-Biotechnology and Nutrition in Semi-Arid Area, Ibn Khaldoun University, Tiaret, DZ
2 Laboratory of Applied Biochemistry and Microbiology, Badji Mokhtar Annaba University, DZ

Abstract

Folic acid or vitamin B9 or pteroylglutamic acid, is a relatively simple molecule with two characteristics; firstly, it must be reduced by 2 or 4 hydrogen atoms to be metabolically active which makes it sensitive to oxidation and must be protected by ascorbic acid, secondly it may include in addition to the constituent residues of the molecule, 1-7 glutamate residue at one of its ends. These polyglutamate forms that make up the largest share of food folate, must be deconjugated by a specific enzyme present in the intestinal lumen before being absorbed in the jejunum. It is in the methylated form after passing through the enterocyte it is transported in the blood, excreted in bile and reabsorbed. It must be demethylated to integrate folic cell cycle and methyl transfer, that allows the synthesis of methionine (only possible in the presence of vitamin B12), purine, serine and especially thymidylic acid, constitutive DNA. As a methyl donor that plays a fundamental role in cerebral and nervous metabolism. Folates are involved in cell division thus; any folic acid deficiency causes a slowdown in rapid multiplication systems which may lead to red blood cell disorders (macrocytic anemia), immunity, and neural tube defects, in addition to physiological disorders (cardiovascular, cancer ...). Folic acid supplementation appears to allow the correction of these disorders.

Keywords

Deficiency, Disorders, Folic Acid, Supplementation.

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