Informatics Publishing Limited

Galib Ruknuddin ¹, B. J. Patgiri ¹, P. K. Prajapati ¹, B. K. Ashok ², B. Ravishankar ³

Affiliations
1 Department of Rasa Shastra and Bhaishajya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, IN
2 Drug Discovery Group, R&D Centre, The Himalaya Drug Company, Makali, Bangalore, IN
3 SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, IN

Abstract

Introduction: Arthritis is the most common cause of disability, limiting the activities of adults throughout the world. Apart from the conventional treatment strategies using non-steroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and glucocorticoids, newer and safer drugs are continuously being searched, as long-term usage of these drugs have resulted in adverse effects. Besides this, currently a number of medicinal plants are under scientific evaluation to develop a promising remedy in these cases. There is a need to investigate the complete therapeutic potential of these herbals for providing newer and safer treatment options with minimum side effects. Considering this, a polyherbal Ayurvedic compound formulation (Dashanga Ghana) has been studied in experimental animals to evaluate anti-arthritic activity. Materials and Methods: Dashanga Ghana has been prepared in the laboratory by following standard guidelines. Charles Foster albino rats were used to evaluate the activity through Freund’s adjuvant induced arthritis model. Results and Conclusions: Dashanga Ghana is found to possess significant anti-arthritic activity. Further studies are required to identify and characterize exact active phyto-constituents and to elucidate the exact mechanism of action, which is responsible for the observed pharmacological profile.

Keywords

Arthritis, Ayurveda, Dashanga Ghana, Freund’s Adjuvant, Paw Oedema.

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Swapnil Y. Chaudhari , Galib Ruknuddin , Patgiri Biswajyoti , Prajapati Pradeep Kumar

Abstract

Introduction: Tamra Bhasma (TB) and its forms like Somnathi Tamra Bhasma (STB), etc., are in vogue since centuries in Ayurveda. The present study is carried out to evaluate the effect of TB and STB in different dose levels on ponderal and biochemical parameters in wistar strain albino rats to provide scientific basis for its safety profile. Materials and Methods: TB and STB were prepared as per the classical guidelines and administered to wistar strain albino rats for 45 consecutive days. Blood was collected and rats were sacrificed on the 46th day. Ponderal and biochemical parameters were studied. Results: Results showed significant decrease in serum cholesterol, High Density Lipoprotein (HDL) cholesterol, triglycerides, total protein, and serum alkaline phosphatase levels. Comparatively, all the differences in between the groups are insignificant and no pathological changes at ponderal and biochemical levels were observed. Conclusion: Based on these observations, it can be said that these formulations can be safely used in cases of hyperlipidemia.

Keywords

Bhasma, biochemical parameters, copper, ponderal parameters, Somnathi Tamra Bhasma, Tamra Bhasma

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