Informatics Publishing Limited

Subhashis Debnath ¹, G. Vijay Kumar ², Debarshi Datta ¹, D. Swetha ¹, M. Niranjan Babu ¹

Affiliations
1 Seven Hills College of Pharmacy, Tirupati, 517 561, A.P., IN
2 Vikas Institute of Pharmaceutical Sciences, Andhra Pradesh, IN

Abstract

Chronopharmaceutics has been described as a branch of pharmaceutics devoted to the design and evaluation of drug delivery system that release a bioactive agent at a rhythm that ideally matches the biological requirement of a given drug therapy. The circadian clock acts like a multifunction timer to regulate homeostatic systems such as sleep and activity, hormone levels, appetite, and other bodily functions with 24h cycles. Diseases such as hypertension, asthma, peptic ulcer, arthritis, etc, follow the body's circadian rhythm. The goal in drug delivery research is to develop formulations to meet therapeutic needs relating to particular pathological conditions. Research in the chronopharmacological field has demonstrated the importance of biological rhythm in drug therapy, and this has brought a new approach to the drug delivery systems. The application of biological rhythm to pharmacotherapy may be correlated by the appropriate timing of dosing of these drug delivery systems to synchronize drug concentrations to rhythms in disease state.

Keywords

Chronopharmaceutics, Bioactive Agent, Circadian Clock, Circadian Rhythm, Chronopharmacological, Pharmacotherapy.

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G. Vijay Kumar ¹, M. Sreedevi ¹

Affiliations
1 School of Computing, K.L.College of Engineering, Vaddeswaram, Guntur (D.T) Andhrapradesh, IN

Abstract

The paper presents the data warehousing architecture and practices used at a major. Retailing company. Many considerations were assessed when deciding which data warehousing architecture to adopt. The paper discusses the two pre-dominant styles in data warehousing, namely the “Bill Inmon Style” or the top-down approach and the “Ralph Kimball Style” or the bottom-up approach. The com-pany chose the Inman style due to a unique combination of circumstances in their business and technical environments, which are being discussed in detail. Much of the information presented in this paper is based upon the direct experiences of the lead data architect assigned to the projects under which this retailing company’s customer data warehouse evolved. The architecture has evolved over time and currently has been accepted at the company as a best practice. It is interesting to mention that both the hardware platform (CPU and disk drives) and Relational Database Management System (RDBMS) soft-ware employed today at this company for data ware-housing is not the same as was selected for the first instantiation. The implication was that the best plan or practice was a flexible one. There were many challenges, like organizational, technical, data sourcing and data naming, needed to be solved during the pre-project, initial stages, and throughout the project and beyond. The initial data warehouse, implemented in 1996, was termed an overall success and approved for expansion. The current data warehouse data are being used by over six hundred registered users to fine-tune customer marketing and leverage and share data in an enterprise manner. The data warehouse has allowed the company to strengthen customer relation-ship management (CRM) core capabilities and business partnerships. Today, there are many departments benefiting from queries and requests for data warehouse data, many anticipated, some not.

Keywords

Data Warehouse, Business Intelligence, CRM.

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A. Anirudh Kumar ¹, A. Vasanth Kumar ², G. Vijay Kumar ¹, G. Prabhakar Rao ¹, S. Nagaraju ¹

Affiliations
1 Department of General Medicine, Santhiram Medical College, Nandyal, Kurnool, Andhra Pradesh, IN
2 Sri Vijaya Durga Cardiac Centre, Kurnool, Andhra Pradesh, IN

Abstract

Super vasmol is an emulsion based hair dye commonly used in India. There is no specific antidote for its main ingredient paraphenylene diamine (PPD) and treatment is mainly supportive. Supervasmol poisoning with bradycardia and reversible left ventricular systolic dysfunction is a rare association. The exact mechanism of the cause is not known. We report a case of 45-year-old female who consumed "SUPER VASMOL" for suicidal purpose and developed sinus bradycardia and reversible left ventricular systolic dysfunction which was treated successfully and discharged. Cardiac manifestations were rare and also life threatening. Unless the patient is monitored continuously and prompt treatment instituted, it may prove fatal.

Keywords

Hair Dye Poisoining, Paraphenylene Diamine (PPD), Reversible Left Ventricular Systolic Dysfunction, Bradycardia.

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