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- H. A. Rabari
- S. S. Pandya
- B. Gajra
- N. P. Upadhyay
- Anil G. Jadhav
- Sachin B. Narkhede
- Mrutyunjay B. Patil
- Atul R. Bendale
- S. M. Sarode
- M. A. Chaudhari
- M. K. Kale
- G. S. Talele
- Prakash S. Sukhramani
- Piyush M. Patel
- A. G. Jadhav
- S. P. Narkhede
- S. B. Narkhede
- Y. A. Chaudhari
- J. U. Somani
- M. Mittal
- P. Sharma
- B. Shrivastava
- G. K. Gajare
- Poonam R. Faldu
- Sandip K. Dadhaniya
- Chirag J. Patel
- Jayk Khunt
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- A. R. Bendale
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- Neha Patel
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- Ashok G. Jiladia
Journals
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Vidyasagar, G.
- Anti-Inflammatory and Wound Healing Activity of Melhania Futteyporensis Munro Ex Masters Leaf
Abstract Views :242 |
PDF Views:2
Authors
Affiliations
1 Veerayatan Institute of Pharmacy, Jakhania, Bhuj-Mandvi Road, Kachchh, Gujarat-370460, IN
2 Pharmacy College, Rampura, Post-Kakanpur, Tal.-Godhra, Panchmahal (District), Gujarat-389713, IN
1 Veerayatan Institute of Pharmacy, Jakhania, Bhuj-Mandvi Road, Kachchh, Gujarat-370460, IN
2 Pharmacy College, Rampura, Post-Kakanpur, Tal.-Godhra, Panchmahal (District), Gujarat-389713, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 3 (2010), Pagination: 233-238Abstract
The methanolic and aqueous extract of Melhania futteyporensis leaves, at the doses of 200 and 400 mg/kg body weight, were tested for antiinflammatory and wound healing activity. The carrageenan induced rat paw edema model was selected to evaluate anti-inflammatory activity. The percentage inhibition of paw edema by the extracts was found to be significant at the dose of 400 mg/kg body weight, compared to control. The exhibited anti-inflammatory activity of Melhania futteyporensis was comparable with the standard drug aspirin. The wound healing activity was evaluated by using excision wound model of albino wistar rats. The percentage of wound contraction by both the methanolic and aqueous extracts was found to be significant at the dose of 400 mg/kg body weight. The exhibited wound healing activity was comparable with the standard drug povidone iodine ointment. The extract treated wounds were found to epithelize faster as compared to controls.Keywords
Melhania futteyporensis, Anti-Inflammatory Activity, Carrageenan Wound Healing Activity.
References
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- Hepatoprotective Activity of Bauhinia variegata Bark against Carbon Tetrachloride Induced Hepatotoxicity in Female Albino Wistar Rats
Abstract Views :225 |
PDF Views:4
Authors
Affiliations
1 Dept. of Pharmacognosy KLES College of Pharmacy, Belgaum, Karnataka, IN
2 Dept. of Pharmacognosy Smt.BNB Swaminarayan Pharmacy College, Salvav (Vapi), IN
3 Veerayatan Institute of Pharmacy, Jakhania, Bhuj-Mandvi Road, Kutch-370460, Gujarat, IN
1 Dept. of Pharmacognosy KLES College of Pharmacy, Belgaum, Karnataka, IN
2 Dept. of Pharmacognosy Smt.BNB Swaminarayan Pharmacy College, Salvav (Vapi), IN
3 Veerayatan Institute of Pharmacy, Jakhania, Bhuj-Mandvi Road, Kutch-370460, Gujarat, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 3 (2010), Pagination: 239-242Abstract
In recent times lot of interest has been generated to find out a natural remedy for hepatic disorders caused by toxins like alcohol and hepatitis virus. The present study is designed and investigate the hepatoprotective activity of Bauhinia variegata bark against carbon tetrachloride (CCl4) induced hepatotoxicity in female Albino Wistar rats. Forty two Albino Wistar female rats were divided in to seven equal groups each containing six animals. Four groups received the extracts of Bauhinia variegata bark and intraperitoneal (i.p.) CCl4 (2 ml/kg) with administration of extracts. One group was control, one treated with CCl4 and one with normal saline. The hepatotoxicity was assessing by plasma concentration of serum bilirubin and enzymes activities. The aqueous extract (500mg/kg b.w.) of Bauhinia variegata bark significantly reduced carbon tetrachloride induce damages in the liver which is measured by SGOT, SGPT, SALP and serum bilirubin levels in blood. The attempt has been made to extract the active constituent and identified by phytochemical investigation and hepatoprotective activity of Bauhinia variegata bark.Keywords
Bauhinia variegataReferences
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- Pokhrel, Naba Raj, R.P. Adhikari and M.P. Baral. In-vitro evaluation of the antimicrobial activity of Bauhinia variegata. World Journal of Microbiology and Biotechnology; 18(1): 69-71(2002).
- Rajkapoor B, Jayakar B, Murugesh N. Antitumour activity of Bauhinia variegata on Dalton's ascitic lymphoma. J Ethnopharmaco.; Nov; 89(1): 107-109 (2003).
- Rajkapoor, B., B. Jayakar, R. Anandan and S. Kavimani. Antiulcer effect of Bauhinia variegata Linn. in rats, Journal of Natural Remedies; 3: 2-4 (2003).
- Rajkapoor, BB, Jayakar and Murugesh N. Antitumour activity of Bauhinia variegata against Ehrlich ascites carcinoma induced mice, Pharmaceutical Biology; 41, 8: 604-607 (2003).
- Reitman, S. and Frankel AS. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol.; 26: 56-57 (1967).
- Shivrajan VV, and Indira B. Ayurvedic drugs and their plants sources, Oxford and IBH publishers, New Delhi; 2004, pp.207.
- The Wealth of India - A Dictionary of Indian Raw Materials and Industrial products. Vol-I, CSIR, New Delhi, 1952. Reprint 1989, pp. 161.
- Vaidya VM, Gogte. Ayurvedic Pharmacology and Therapeutic uses of medicinal plant. Published by Shri S. Ramkrishanan Executive Secretary, Bhartia Vaidya Bhavan, Kulapati manshi marg, Mumbai; Reprint 2000, pp. 340.
- Yadava RN, Reddy VM. Anti-inflammatory activity of a novel flavonol glycoside from the Bauhinia variegata Linn ; Nat Prod Res.17(3):165-9 (2003).
- Computer Literacy in Pharmacy Students (A Survey Carried out at Smt. B. N. B. Swaminarayan Pharmacy College, Affiliated to GTU, Gujarat)
Abstract Views :215 |
PDF Views:0
Authors
Affiliations
1 (Dept. of Pharmaceutical Chemistry) Smt. B. N. B. Swaminarayan Pharmacy College, NH-08, Salvav (Vapi), Gujarat, IN
2 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
3 Kutch University, Bhuj, Gujarat, IN
1 (Dept. of Pharmaceutical Chemistry) Smt. B. N. B. Swaminarayan Pharmacy College, NH-08, Salvav (Vapi), Gujarat, IN
2 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
3 Kutch University, Bhuj, Gujarat, IN
Source
Research Journal of Science and Technology, Vol 3, No 1 (2011), Pagination: 29-33Abstract
The purpose of this study was to determine first-year bachelor of pharmacy student's computer backgrounds and attitudes. Fifty students from Smt. B. N. B. Swaminarayan Pharmacy College, Salvav, Vapi (Gujarat) completed a survey that assessed their computer experience, types of software used, and attitudes about computers. From this survey it is come to know that 24% students are daily user of computers, 30% students used computer once in a month, 16% twice in a month and 14% thrice in a month. one important aspect observe that all students (100%) are aware of computer applications in pharmaceutical field. Most (78%) had home computers; however, 20% said they relied on a school-based computer laboratory. Software use ranged from a high of 96% (MS WORD) to a low of 4% (Statistical Package). In case of MS-Office- 86% students have basic skill, 13% have intermediate skill and 1% has an expert skill. Most indicated positive attitudes about computers they feel apprehensive about learning to use a PC (88%). Students viewed computers as important parts of their professional education, but appeared to want courses that included both computer and human components. These findings suggest that faculty should consider differences in student's attitudes about and experiences with computers when planning computer-based course assignments and developing computer-based instructional innovations in Pharmacy field.- Preparation and Characterization of Self Emulsifying Drug Delivery System (SEDDS)
Abstract Views :153 |
PDF Views:0
Authors
Affiliations
1 C/O M. B. Sarode, Shanti Nagar, Plot no.6, Yawal road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
1 C/O M. B. Sarode, Shanti Nagar, Plot no.6, Yawal road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 4 (2010), Pagination: 290-294Abstract
A mixture of oil and surfactant (especially non-ionic) forms clear and transparent isotropic solution known as self-emulsifying system (SES). Lovastatin is HMG-CoA enzyme inhibitor. This enzyme is needed by the body to make cholesterol. Lovastatin causes cholesterol to be lost from LDL, but also reduces the concentration of circulating LDL (low density lipoprotein) particles. Animals studies demonstrated that lovastatin crosses the blood-brain and placental barriers. Elderly patients or those with renal insufficiency may have higher plasma concentrations of lovastatin after administration and may require a lower dose. SEDDS is prepared and filled in hard gelatin capsules. In vitro dissolution indicates that the release of lovastatin from SEDDS varied according to the type and ratio of the oil and surfactants. It was concluded that there was an increase in both the solubility and dissolution rate of drug in SEDDS form as compared to marketed tablet.Keywords
SEDDS, Enzymes.- Formulation and Evaluation of Antihypertensive Microparticulate Drug Delivery System
Abstract Views :184 |
PDF Views:0
Authors
Affiliations
1 C/O M. B. Sarode, Shanti Nagar, Plot No.6, Yawal Road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
3 J.Z.M.D.S. College of Pharmacy, Mamurabad, IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
1 C/O M. B. Sarode, Shanti Nagar, Plot No.6, Yawal Road, Bhusawal (M.S.), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon (M.S.), IN
3 J.Z.M.D.S. College of Pharmacy, Mamurabad, IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 3 (2010), Pagination: 237-240Abstract
The phenomenon of absorption via a limited part of the GI tract has been termed the "narrow absorption window", once the dosage form passes the absorption window, the drug will be neither bioavailable nor effective. In extreme cases, drugs, e.g. methyldopa, Captopril, that are insufficiently absorbed due to narrow absorption cannot be delivered entirely, and are either given by a parentral route, or the development of such medication, which is otherwise safe and effective, is stopped altogether. Diltiazem HCL is a calcium channel blocker widely used for the treatment of angina pectoris, arrhythmias and hypertension. Its short biological half life and thus frequent administration (usually three to four times a day) makes it a potential candidate for CR: SR preparations. It has a short plasma half life of about 3 hours. Diltiazem HCL microspheres were prepared by chemical cross linking method. The microspheres were spherical, discrete and free-flowing. Encapsulation efficiency was found to be 95.62 %. Diltiazem HCL release from microspheres was slow and diffusion controlled. Good liner relationships were observed between percent coat and release rate of the microspheres.Keywords
Microencapsulation, Controlled Release, Chitosan.- In-vitro Screening of Ficus racemosa for Anticancer Activity
Abstract Views :182 |
PDF Views:0
Authors
Affiliations
1 JJT University, Vidyanagari, Jhunjhunu – Churu Road, Dist: Jhunjhunu, Rajasthan – 333001, IN
2 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi – 370460, Dist: Kutch, Gujarat, IN
3 Shree B.M Shah College of Pharmaceutical Education and Research, Modasa - 383315, Dist: Sabarkantha, Gujarat, IN
1 JJT University, Vidyanagari, Jhunjhunu – Churu Road, Dist: Jhunjhunu, Rajasthan – 333001, IN
2 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi – 370460, Dist: Kutch, Gujarat, IN
3 Shree B.M Shah College of Pharmaceutical Education and Research, Modasa - 383315, Dist: Sabarkantha, Gujarat, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 5, No 3 (2013), Pagination: 119-122Abstract
Ficus racemosa is a moderate sized avenue tree found throughout India. It is popular in indigenous system of medicine like Ayurveda, Siddha, Unani and Homoeopathy. Aim of the present study was undertaken with an objective to find out the anticancer activity of Ficus racemosa plant extracts using standard in-vitro MTT bioassay against various cancer cell lines (HL-60, HepG2, NCI-H23 and HEK-293T). With use of MTT dye, % cell viability and % inhibition of the hit compounds was evaluated within respective wavelengths prior with standard compounds. Data obtained from MTT bioassay screening revealed that methanolic extract of Ficus racemosa shown cytotoxic activity against HL-60 and HepG2 cell line with profound IC50 values and shown negligible toxicity against normal cell line (HEK- 293T).Keywords
Ficus racemosa Linn., MTT Bioassay, Anticancer Activity.- Formulation and Evaluation of Ethyl Cellulose Coated Microspheres of Aceclofenac
Abstract Views :170 |
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Authors
Affiliations
1 C/O M. B. sarode, Shanti Nagar, Plot no.6, Yawal Road , Bhusawal (M.S.), IN
2 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
3 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
1 C/O M. B. sarode, Shanti Nagar, Plot no.6, Yawal Road , Bhusawal (M.S.), IN
2 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
3 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 41-43Abstract
The pain is symptomatic of some form of dysfunction and resultant inflammatory processes in the body. More than 15% of the worldwide population suffers for instance from some form of osteoarthritis and this incidence is even higher in elderly. As the world population is grows older, this incidence will continue to rise. Aceclofenac has been shown to have potent analgesic and anti-inflammatory activities and due to its preferential cox-2 blockade it has better safety than conventional NSAIDs with respect to adverse effects on gastrointestinal and cardiovascular system. Ethyl cellulose microspheres of Aceclofenac were prepared by emulsion- solvent evaporation technique that is an industrially feasible technique. The microspheres are spherical, discrete and free-flowing. Encapsulation efficiency was found to be 81%. Aceclofenac release from microspheres was slow and diffusion controlled. Good liner relationships were observed between percent coat and release rate of the microspheres. These microspheres were found suitable for oral controlled release.
Keywords
Microencapsulation, Controlled Release, Aceclofenac.- Isolation of Cordia rothii Roxb Mucilage and Its Comparative Evaluation as a Binding Agent with Standard Binder
Abstract Views :167 |
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Authors
Affiliations
1 Veerayatan Institute of Pharmacy, Kutch-370 460, Gujarat, IN
2 Department of Pharmacognosy, Smt. B.N.B. Swaminarayan Pharmacy College, Salvav, Vapi, Pin: 396191, Gujarat, IN
3 Department of Pharmacy, Jodhpur National University, Narnadi, Jodhpur, Rajasthan, IN
1 Veerayatan Institute of Pharmacy, Kutch-370 460, Gujarat, IN
2 Department of Pharmacognosy, Smt. B.N.B. Swaminarayan Pharmacy College, Salvav, Vapi, Pin: 396191, Gujarat, IN
3 Department of Pharmacy, Jodhpur National University, Narnadi, Jodhpur, Rajasthan, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 6 (2010), Pagination: 472-475Abstract
Cordia rothii Roxb. found wild in the forest region, drupe usually single seeded containing mucilage. To isolate mucilage pulp is removed and the seed were macerated with water then filter. Acetone precipitation method is used to isolate mucilage from filtrate and dried in vacuum dryer at 40°C. The physicochemical characteristic of mucilage has performed such as swelling index, solubility, loss on drying. This study was carried out to compare the binding effects of isolated mucilage with starch. Granule properties such as angle of repose, moisture content, bulk and tapped densities and tablet properties which included weight uniformity, friability, disintegration times, and dissolution rates using standard methods. Mucilage of varying concentrations of 8, 10 and 12%w/w were used to produce aceclofenac granules by wet granulation method and compressed into tablets at arbitrary pressure load unit of 6 tons. An increase in binder concentration led to decrease in friability and increase in disintegration time of the tablets. The results indicate that mucilage obtained from Cordia rothii fruit possesses comparable binding properties.Keywords
Cordia rothii, Binder, Aceclofenac, Mucilage.- Antimicrobial Studies on Selected Medicinal Plants in Khandesh Region, Maharashtra, India
Abstract Views :164 |
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Authors
Affiliations
1 Gandhi Chowk, Savda, Dist-Jalgaon, IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
3 TVES’S Hon’ble L. M. C. College of Pharmacy, Faizpur, IN
4 Department of Pharmacology, K.Y.D.S.C.T’s College of Pharmacy, Sakegaon- 425201, IN
1 Gandhi Chowk, Savda, Dist-Jalgaon, IN
2 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
3 TVES’S Hon’ble L. M. C. College of Pharmacy, Faizpur, IN
4 Department of Pharmacology, K.Y.D.S.C.T’s College of Pharmacy, Sakegaon- 425201, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 5 (2010), Pagination: 386-390Abstract
Medicinal plants contribute in human health care system. Most of the plants utilized by village peoples as a folk medicine. Now we are turned in to medicinal plant analysis of active compounds and conservation aspect. In the present study we had select the four important medicinal plants in the Khandesh region. Such plants are widely used in this region for ayurvedic purpose by villagers and local herbal health masters. We have colleted four medicinally important medicinal plants such as Acalypha indica, Cassia auriculata, Eclipta alba and Phyllanthus niruri for antimicrobial studies. The experiment carried out in the selected medicinal plants leaves and ischolar_mains. The results are discussed with the available literature.- Pharmacognostical and Phytochemical Studies of Melhania futteyporensis Munro ex Masters Leaf
Abstract Views :138 |
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Authors
Affiliations
1 Veerayatan Institute of Pharmacy, Jakhania-Mandvi, Kachchh, Gujarat-370460, IN
2 Pharmacy College, Rampura-Kakanpur, Panchmahal (District), Gujarat-389713, IN
1 Veerayatan Institute of Pharmacy, Jakhania-Mandvi, Kachchh, Gujarat-370460, IN
2 Pharmacy College, Rampura-Kakanpur, Panchmahal (District), Gujarat-389713, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 1 (2010), Pagination: 52-56Abstract
The leaves of Melhania futteyporensis Munro ex Masters (Sterculiaceae) are reported to have good medicinal values in traditional system of medicines. The present study deals with pharmacognostical examination of morphological and microscopical characters and phytochemical investigations of Melhania futteyporensis leaves including determination of loss on drying, ash values and extractive values. The preliminary phytochemical screening of powdered drug was also carried out. The qualitative chemical examinations revealed the presence of various phytoconstituents like carbohydrates, saponins, phenolic compounds and mucilages in the leaf extracts.Keywords
Melhania futteyporensis, Hanju, Leaf Microscopy, Phytochemical Screening.- Preparation and Evaluation of Inclusion Complexes Using Cyclodextrins and Its Derivatives
Abstract Views :154 |
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Authors
Affiliations
1 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, IN
2 Bhagwan College of Pharmacy, Aurangabad, IN
3 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
1 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, IN
2 Bhagwan College of Pharmacy, Aurangabad, IN
3 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 5, No 1 (2012), Pagination: 131-135Abstract
Domperidone is a widely used antiemetic, poorly water soluble drug, erratically absorbed in stomach and possess several dissolution related problems thus it has poor bioavailability. Solubility of a drug plays a very important role in dissolution and hence absorption of drug which ultimately affects its bioavailability. Hence, by considering the facts related to drug, attempts have been made to formulate inclusion complexes using various derivative of cyclodextrins.
Inclusion complexes were prepared using methylated betacyclodextrin and hydroxy propyl betacyclodextrin in 1:1 and 1:2 molar ratios. Kneading, ultrasonification and physical mixture method were used for preparation of inclusion complexes. The solubility and dissolution results revealed that there was an increase in solubility and dissolution of all inclusion complexes as compared to pure drug but was highest in case of methylated betacyclodextrin in 1:1molar ratio using ultrasonification method(USM1) and with hydroxypropyl betacyclodextrin in 1:2 molar ratio using ultrasonification method(USHP2).
Keywords
Cyclodextrins , Inclusion Complex.- Multi-Component Reaction and their Application in Drug Discovery
Abstract Views :217 |
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Authors
Affiliations
1 Veerayatan Institute of Pharmacy, Mandvi-Kutch, Gujarat, IN
2 R.B. Patel Mahila Pharmacy College, Atkot, Gujarat, IN
1 Veerayatan Institute of Pharmacy, Mandvi-Kutch, Gujarat, IN
2 R.B. Patel Mahila Pharmacy College, Atkot, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 12 (2011), Pagination: 1818-1824Abstract
Multicomponent reactions (MCRs) provide a powerful tool towards the one-pot synthesis of diverse and complex compounds on the one hand and small and 'drug-like' heterocycles on the other hand. No other single synthesis technology enables chemists to search such large chemical spaces as provided by MCRs. This review describes various three component and four component reaction example and recent advances in the application of isocyanide-based multicomponent reactions (IMCRs) in drug discovery.Keywords
Multicomponent Reaction, Three Component Reaction, Four Component Reaction, Application, Isocyanide Based Reaction.- Mechanochemistry-A New Era in Synthesis for Pharmaceutical Researchers
Abstract Views :217 |
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Authors
Atul R. Bendale
1,
Jayk Khunt
1,
Sushil P. Narkhede
1,
Sachin B. Narkhede
1,
Anil G. Jadhav
1,
G. Vidyasagar
2
Affiliations
1 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
2 Dean (Pharmacy Department) Kutch University, Bhuj, Gujarat, IN
1 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
2 Dean (Pharmacy Department) Kutch University, Bhuj, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 6 (2011), Pagination: 851-856Abstract
Mechanochemistry is the emerging branch of chemical science which obeys the principles of green chemistry. The power of mechanical friction is the source of energy for completion of reaction. Basically it was classified in the metallurgical sciences but due to its compatibility and ease of practice it will readily adopted in science of chemical synthesis. Organics as well as inorganic substances can be subjected to modification by virtue of it. It appears to be a science with a sound theoretical foundation which exhibits a wide range of potential application. The simplest and best example is of KBr plates; it will induced by milling and pressing of analyte with KBr to form a disk for IR spectroscopy, resulting in a change of the spectrum of the analyte. So it was worthwhile to adopt this technique in synthesis of pharmaceuticals.Keywords
Green Chemistry, Mechanochemistry, Mechanical Friction, Synthesis.- Preparation and Evaluation of Anti-Inflammatory Transdermal Drug Delivery System
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Authors
S. M. Sarode
1,
A. R. Bendale
2,
M. Mittal
1,
M. A. Chaudhri
3,
M. K. Kale
3,
G. Vidyasagar
4,
B. Shrivastava
5
Affiliations
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur- 425201, IN
2 B.N.B.Swaminarayan College of Pharmacy, Vapi, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
5 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, IN
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur- 425201, IN
2 B.N.B.Swaminarayan College of Pharmacy, Vapi, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
5 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 5 (2011), Pagination: 791-794Abstract
An abundance of the anti-inflammatory drugs are available for use in current medicine which have an established use in the treatment of arthritis and other painful conditions, amongst them one of the novel drug is Aceclofenac. Gels are an excellent formulation for several routes of administration such as oral, topical, nasal, vaginal, and rectal. Gel can be clear formulations when all of the particles completely dissolve in the dispersing medium. But this doesn't occur in all gels, and some are therefore turbid. This need has emphasized the importance of developing a topical dosage form of such drugs.
Aceclofenac is novel non steroidal anti-inflammatory drug which have proven its effectiveness in many of painful diseased conditions like osteoarthritis, rheumatoid arthritis, spondylitis etc. Like other NSAIDs it is also associated with adverse effects, majority of them are of gastrointestinal system (dyspepsia, abdominal pain, nausea and diarrhea). Present study was undertaken to develop an effective and stable topical formulations of Aceclofenac gel.
Keywords
TDDS, Aceclofenac.- Sonochemical Synthesis of 2, 3-Diphenylquinoxaline Using Different Catalysts, a Green Chemistry Approach
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Authors
Atul R. Bendale
1,
Neha Patel
1,
Sushil P. Narkhede
1,
Sachin B. Narkhede
1,
Anil G. Jadhav
1,
G. Vidyasagar
2
Affiliations
1 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
2 Dean (Pharmacy Department) Kutch University, Bhuj, Gujarat, IN
1 Smt. B. N. B. Swaminarayan Pharmacy College, Salvav (Vapi), Gujarat, IN
2 Dean (Pharmacy Department) Kutch University, Bhuj, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 6 (2011), Pagination: 887-889Abstract
A simple, highly efficient and green procedure for the condensation of aryl and alkyl 1, 2-diamines with α-diketones in the presence of different catalyst at room temperature is described. And the recycled catalyst was used for the next run under identical reaction conditions. Using this method, quinoxaline derivatives as biologically interesting compounds are produced in high to excellent yields and short reaction times. Present synthesis complies with principle of Green chemistry. As part of current studies, we here in report efficient practical technique of sonication reaction (sonosynthesis). The overall progress of the reaction was monitored by TLC and characterized by IR and NMR. Compared with traditional methods, these methods are more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. The synthesized 2, 3-diphenyle quinoxaline was confirmed by physical constant and spectroscopic studies. Low cost, reuse of worn catalyst and maximum efficiency are some advantages of this synthesis. Compared with traditional method, this method is more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. From these features present methods can be correlated for safer and efficient synthesis of other products.Keywords
Sonochemistry, Quinoxaline, Catalyst.- Estimation of Rosiglitazone in Bulk and Tablet Dosage Forms by HPTLC Method
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Authors
Affiliations
1 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi-370460, IN
2 Babaria Institute of Pharmacy, Vadodara-391240, IN
3 Jiladia Hospital, New Anjar, Anjar (Kutch)-370110, IN
1 Veerayatan Institute of Pharmacy, Bhuj-Mandvi Road, Jakhania, Mandvi-370460, IN
2 Babaria Institute of Pharmacy, Vadodara-391240, IN
3 Jiladia Hospital, New Anjar, Anjar (Kutch)-370110, IN