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R. Deivendran ¹, G. Vanithakumari ¹

Affiliations
1 Department of Zoology, Bharathiar University, Coimbatore 46, IN

Abstract

Ciprofloxacin, a non-steroidal antiinflammatory drug was screened for its probable toxicity on male accessory sex organ, the epididymis, at different doses (250 mg and 400 mg/60 kg bwt/day respectively, for seven consecutive days). The drug had caused an increase in body weight and organ weights but it had lowered in sperm count, sperm motility as well as the activities of steroidogenic enzymes were also adversely affected. The above adverse changes in epididymal function indicate the toxic effect of ciprofloxacin. Drug withdrawal for 14 days in high dose groups could not reverse the adverse biochemical changes suggesting the permanent effect of the drug.

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K. Sakthishree ¹, M. Selvaraj ¹, G. Vanithakumari ¹

Affiliations
1 Department of Zoology, Bharathiar University, Coimbatore-641046, IN

Abstract

The effects of diclofenac sodium on the activities of the steroidogenic enzymes 3β-Phydroxy steroid dehydrogenase and 17β-Phydroxy steroid dehydrogenase as well as testosterone hormone titres were studied in albino rats, at a dosage of 300μg/kg. body weight for short, mid and long duration treatments. The effect of withdrawal of the drug for a month and supplementation with vitamin E were also studied.

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M. Selvaraj ¹, G. Vanithakumari ¹

Affiliations
1 Department of Zoology, Bharathiar University, Coimbatore-641046, IN

Abstract

Non-steroidal anti-inflammatory drug, diclofenac sodium (Voveran) was injected intramuscularly at 1.5mgand3.0mg/kgbody weight respectively and vitamin E was administered orally at 4.0 mg/kg body weight for a period of 4 weeks to adult male albino rats. Low dose of diclofenac given for 4 weeks brought about marked reduction in the caudal tubular diameter. The infiltration of intra tubular connective tissue were pronounced.

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G. Vanithakumari ¹, K. Banu Arifa ¹, R. Deivendran ¹, C. Anbalagan ¹

Affiliations
1 Division of Endocrinology, Department of Zoology, Bharathiar University, Coinibatore-641046, IN

Abstract

The effect of ibuprofen in two different doses (1.5mg and 3mg/100gram b. wt/day, respectively for 7 days) was screened in male albino rats with special reference to body weight, organ weight and structure of thyroid gland. The drug had not caused any significant change in body weight in all the treatment groups. The weight of the gland was increased in low dose ibuprofen treated group and decreased in high dose treatment group. The histological studies revealed modest enlargement, increased hyperplasia of central microfollicular and macrofollicular cells, with the latter having significant colloid accumulation and central positioning in low dose drug treated animals.

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G. Vanithakumari ¹, K. Banu Arifa ¹, R. Deivendran ¹, C. Anbalagan ¹

Affiliations
1 Department of Zoology, Bharathiar University, Coimbatore-641046, IN

Abstract

Ibuprofen, a new generation non-steroidal anti-inflammatory drug, widely used world over, was studied for its probable effect on body weight, organ weight and structure of adrenal gland in male albino rats. Two different drug doses (1.5mg and 3mg/100 gram b. wt/day, respectively) were given to the animals for seven consecutive days.

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