Informatics Publishing Limited

Ashok P. Pingale ¹, A. R. Rote ², R. B. Saudagar ³, Rima R. Patil ², G. B. Jadhav ³

Affiliations
1 Department of Pharmaceutical Chemistry, MVP College of Pharmacy, University of Pune, Maharashtra, Nashik 422002, IN
2 Department of Pharmaceutical Chemistry, M.G.V’s Pharmacy College (Pune University), Mumbai, IN
3 KCT’s R. G. Sapkal College of Pharmacy, Anjineri, Nashik, Maharashtra, IN

Abstract

Spectrophotometric method were proposed for the simultaneous analysis of Drotaverine HCl and Nimesulide in a tablet formulationby absorbance ratio method at 278 nm (isoabsorptive point) and 304 nm(λ max of Drotaverine HCl ) with mean percentage recovery 98.25%±0.66 and 100.5%±0.95, respectively. Beer's law for both methods was obeyed in the concentration range 5-25μg/ml of drotaverine HCl and Nimesulide respectively. The suggested method were successfully applied for the analysis of the two drugs in their pharmaceutical formulation. The obtained results were statistically agreed with those obtained by the reported method.

Keywords

Drotaverine HCl, Nimesulide, Absorbance Ratio Method.

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