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Hassan, Ekram M.
- Kinetic Method for the Determination of Cisapride in Pharmaceutical Preparations
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Authors
Affiliations
1 Department of Analytical Chemistry, College of Pharmacy, Alexandria University, EG
2 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, SA
1 Department of Analytical Chemistry, College of Pharmacy, Alexandria University, EG
2 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, SA
Source
Scientia Pharmaceutica, Vol 68, No 3 (2000), Pagination: 281-296Abstract
An accurate kinetic method for the determination of cisapride is described. The method is based on the reaction of cisapride with potassium dichromate in 2.5 M sulphuric acid at room temperature for a fixed-time of 10 min, afterwards the absorbance of the reaction product is measured at 527 nm. The concentration of cisapride is computed using the corresponding calibration equation for the fixed-time method. The method is applied successfully to commercial tablets and oral suspension dosage forms. The results obtained are compared statistically with the British Pharmacopoeia method. The determination of cisapride by other kinetic methods is feasible with calibration equation obtained but the fixed-time method proves to be more applicable.Keywords
Kinetic Method, Cisapride, Pharmaceutical Preparations.References
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