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E. Thirupavai ¹, S. Veni ¹, S. Sitta Djody ¹, R. Ilangovan ¹, M. Balaganesh ¹, N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, IN

Abstract

Bone marrow is a complex tissue, which contains stem cells for haematopoietic and mesenchymal lineage. Among various growth factors that regulate bone remodeling, TGF-bl is the major growth fator, which is synthesized and stored in bone in large amount. But, the exact role of TGF-bl on the differentiation and mineralization of bone marrow stem cells (BMSCs) is still not clear. Hence, the present study is designed to delineate the role of rhTGF-bl on the differentiation and mineralization of rat BMSC in vitro. Bone marrow stem cells were isolated from the femur bones of healthy rats and cultured with osteogenic medium (OM).

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S. Veni ¹, E. Thirupavai ¹, S. Sitta Djody ¹, R. Ilangovan ¹, N. Srinivasan ¹

Affiliations
1 Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai-600113, IN

Abstract

Bone marrow stem cells (BMSC) develop into pre-osteoblast, mature into osteoblast and attain sensitivity as osteocytes. Among the potential regulators of bone formation, insulin like growth factor-I (IGF-I) occupies an important position because of its ability to stimulate osteoblast proliferation and differentiation. Although, it is well known that osteoblasts are important target cell types, little is known about the effect of rhIGF-I on osteoprogenitors.

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