Informatics Publishing Limited

Dasari Nirmala ¹, Swapna Nandhini ¹, M. Sudhakar ¹

Affiliations
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally and Secunderabad -500100 Affiliated to Osmania University, IN

Abstract

Present research was aimed with the objective of formulation of Zolpidem fast dissolving oral films, for rapid dissolution of drug and absorption, which may produce the rapid on set off action. The fast dissolving oral films were prepared by solvent casting method using various polymers like HPMC E5, HPMC E15, HPMC K15, microcrystalline cellulose and poly vinyl alcohol. Glycerol used as plasticizer. Prepared films were evaluated for various physicochemical parameters like film thickness, tensile strength, folding endurance, content uniformity, estimation of moisture content, disintegration studies and dissolution studies. As polymer concentration increases thickness increases. Thickness directly proportion to tensile strength so as thickness increases tensile strength also increases. Folding endurance increases as polymer concentration increases. The moisture uptake studies revealed that, the film take up very little moisture (1-2%) in high humid environment, hence this may favors the stability as well as compatability. In vitro drug release studies reveals that among all formulations F7 formulation highest amount of drug release compared to other formulations, hence F7 formulation was taken as optimized formulation for further studies. Short term stability studies were conducted for optimized formulation up to 3 months at 40±2c 75% R.H. after stability studies films were transparent all physical parameters were favorable and drug release was satisfactory.

Keywords

Fast Dissolving Films, Zolpidem, Solvent Casting Method, HPMC E5, E15 and K15, Oral Thin Films.

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Dasari Nirmala ¹, Enjamuri Aslesha ¹, M. Sudhakar ¹

Affiliations
1 Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad-500100, Telangana State affiliated to Osmania University, IN

Abstract

The present study was carried out with an objective of formulation and evaluation of floating tablets of baclofen for prolongation of gastric residence time with a view to deliver the drug at controlled manner in gastrointestinal tract and consequently into systemic circulation. Baclofen, a centrally acting skeletal muscle relaxant, is indicated in the long-term treatment of spasticity resulting for multiple sclerosis and spinal cord injuries. Therefore baclofen floating tablets were prepared by direct compression method using 3 grades of Eudragit (Eudragit L100, Eudragit S100, and Eudragit RSPO). Fourier transform Infrared spectroscopy confirmed the absence of any drug/polymers/excipient interactions. The prepared floating tablets were evaluated for hardness, weight variation, thickness, friability, drug content uniformity, total floating time, water uptake (swelling index) and in-vitro dissolution studies. Among the 12 formulations F3 showed drug release 98.37% in pH 1.2 dissolution medium. All the formulations showed drug content ranging from 80.93 to 98.37%. Drug release rate kinetics studies shown that drug release follows Higuchi mechanism.

Keywords

Floating Tablets, Floatation, Sustained Release, Baclofen, Direct Compression, Eudragit.

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Dasari Nirmala ¹, Vaddi Harika ¹, Muvvala Sudhakar ¹

Affiliations
1 Malla Reddy College of Pharmacy, Department of Pharmaceutics, Maisammaguda, Dhulapally, Secunderabad - 500100 Affiliated by Osmania University, IN

Abstract

The aim of present study was to formulation and evaluation of Mucoadhesive buccal tablets of Resperidone. Mucoadhesive buccal tablets of Resperidone were prepared by direct compression method using polymers such as Karaya gum, tamarind gum, carbopol, and Sodium carboxy methyl cellulose. The Buccal tablets were evaluated for various physical, drug content uniformity, in-vitro drug release and drug- excipient interactions (FT-IR). FT-IR spectroscopic studies indicated that there were no drug-excipient interactions. The formulation F9 (containing 30mg of Carbopol) were found to be best formulation, which showed maximum drug release within 8 h. These formulations have showed good bioadhesion strength (18 gm).

Keywords

Risperidone, Mucoadhesive Buccal Tablets, Carbopol, Karaya Gum, and Sodium Carboxy Methyl Cellulose

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