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F. Nikhat ¹, D. Satyanarayana ¹, M. G. Purohit ¹, M. A. Hadi ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy, Gulbarga-585201, IN

Abstract

The main objective of the present investigation is to evaluate the analgesic activity of formulate topical gel containing ScReX-2b 2%, Carbopol 940 1.0%, Triethanol amine 0.50%, Propylene glycol 10%, Methanol 2.5% Water 100ml and evaluated for the same.

Keywords

Analgesic, Topical, Gel, Evaluated.

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F. Nikhat ¹, D. Satyanarayana ², D. K. Suresh ², M. G. Purohit ², H. Raza ², S. M. Hamza ²

Affiliations
1 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy, Gulbarga-585201, IN
2 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy, Gulbarga-585201, IN

Abstract

The present study was carried out to investigate the analgesic activity of the prepared formulation 50mg/kg and 200mg/kg body weight in the form of gel on albino rats by Tail immersion method. The different dose level of prepared gel was applied to the rat according to the body weight to the tail which is marked at 5cm and was subjected to analgesic activity. The significance analgesic activity is observed after 1_/2 hr of the application which was compared with standard dichlofenac gel, the activity decreased after 2 hr of the application. The gel was prepared from the isolated constituents of syzygium cuminii (L) skeel ischolar_main extract. The aim of the work is to prepare such a formulation which is having natural analgesic activity. The expected result from the formulation was obtained for first time. The further work is going on in our laboratory.

Keywords

Analgesic, Dichlofenac Gel, Formulation, Constituents.

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F. Nikhat ¹, D. Satyanarayana ¹, E. V. S. Subhramanyam ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Mangalore-574160 Karnataka, IN

Abstract

The object of this review is to highlight the importance of multipurpose indigenous plant Zizyphus mauritiana Lamk Belonging to the family Rhamnaceae . It has been used for centuries as folk remedy in India to treat different disease such as antidiabetic, antioxidant, anti-inflammatory and neurological disorders such as sedative hypnotics, overine complication. It contain several constituent belonging to category alkaloide, Glycoside , flavanoids, triterpinoides, steroids and fruit pulp contain important nutrients . There are five reports are available on the clinical uses of this plant. Indeed the purpose is to outline the Research student to explore the Phytochemistry and pharmacology of indigenous system of medicine. This was a simple tribute to focus on the economical importance of Indian medicinal plants.

Keywords

Zizyphus mauritiana Lamk, Rhamunaceae, Antidiabetic, Antioxidant, Anti-Inflammatory, Alkaloids, Glycoside, Flavanoids, Triterpinoides, Steroids.

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F. Nikhat ¹, D. Satyanarayana ¹, M. G. Purohit ¹, Bharat ¹, A. Moid ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy, Gulbarga-585201, IN

Abstract

Syzygium cuminii (L) skeel commonly known as 'jamun' is widely used in Indian folk medicine for the treatment of diabetes Mellitus. The present study an attempt has been made to produce a complete analytical and chemical profile of the isolated constituents of ischolar_main's of syzygium cuminii(L) skeel . The pharmacological and pharmaceutical work is going on in our laboratory.

Keywords

Syzygium cuminii (L) skeel, Constituents, Diabetes.

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F. Nikhat ¹, D. Satyanarayana ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Luqman College of Pharmacy Gulbarga-585201, IN

Abstract

The present study depends on the collection of plant material authentication, extraction, isolation, characterization and toxicity study. The aim of the present work is to isolate the pure plant material in a signal form to carry out the pharmacological activity.

Keywords

Authentication, Extraction, Isolation, Characterization, Toxicity.

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D. Sri Lakshmi ¹, Jane T. Jacob ², D. Srinivasa Sastry ¹, D. Satyanarayana ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Aditya Pharmacy College, Surampalem, Andhra Pradesh, IN
2 Nitte University, NGSMIPS, Department of Pharmaceutical Chemistry, Mangalore, Karnataka, IN

Abstract

A simple, sensitive and precise RP-UPLC method for estimation of Metformin, Glimeperide and Voglibose has been developed and validated for determination of compounds in commercial tablet dosage form. The compounds were well separated isocratically on a Inertsil ODS column using a mobile phase consisting of buffer (pH 3), and Methanol in the ratio of 70:30 v/v 0.4 ml/min flow rate with PDA detector. Retention time for Metformin, Glimeperide and Voglibose was found to be 0.903, 2.619, 3.818 min respectively. The method was validated in accordance with ICH guidelines. The study showed that the reverse phased liquid chromatography was sensitive and selective for detecting Metformin, Glimeperide and Voglibose using the single mobile phase.

Keywords

Metformin, Glimeperide, Voglibose Ultra Performance Liquid Chromatography, Validation, Degaradation.

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D. Satyanarayana ¹, T. V. S. R. K. Prasad ¹

Affiliations
1 Mechanical Engg. Dept., Vignan's Engg. College, Vadlamudi, Guntur Dist., IN

Abstract

Today's production planning and control strategies have to deal with an increasingly dynamic environment, shorter production cycles, customized products, smaller batches and technological constraints are some of the factors that stretch the actual job scheduling strategies to the limit. Number of optimization techniques are available to solve these type problems. Combinatorial optimization problems are too difficult to be solved optimally, and hence heuristics are used to obtain "good" solutions in reasonable time. Many optimization problems from the industrial engineering world, in particular the manufacturing systems are very complex in nature and quite hard to solve by conventional optimization techniques. The specific goal of this paper is to do a comparative evaluation of Genetic Algorithm with conventional heuristic algorithms. The Genetic Algorithm (G.A.) is a potentially powerful tool for solving complex optimization problems. In this paper, the heuristic procedures considered are (1) Palmer's algorithm (2) Dannenbring's Rapid Access algorithm (3) C. D. S. (Campbell dudek and smith) algorithm. The results are compared and evaluated for the objective of minimizing the makespan.

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Akash P. Dahake ¹, D. Satyanarayana ¹, Arun B. Joshi ¹, K. S. Chandarshekhar ¹, Himanshu Joshi ¹

Affiliations
1 Dept. of Pharmacognosy, N.G.S.M Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore-574160, IN

Abstract

The investigation was carried out to study the antihyperglycemic effects of ethanolic extract of Anacardium occidentale leaves in normal, glucose loaded and alloxan induced diabetic rats. The ethanolic extract of A. occidentale at a dose of 100, 200, 400 mg/kg of body weight (p.o) and standard drug glibenclamide 500 μg/kg, in all three animal models. The serum glucose level was determined at 0, 4, 8 and 12 days after treatment. The extract exhibited significant hypoglycemic activity in all three animal models when compared with a standard antidiabetic agent Glibenclamide. The hypoglycemia produced by the extract may be due to increased uptake of glucose at tissue level and or increase in pancreatic β-cell function or due to inhibition of intestinal glucose absorption of glucose. The study indicated that the ethanolic extract of Anacardium occidentale is a potential antidiabetic agent and lends scientific support for it’s use in folk medicine.

Keywords

Anacardium occidentale, Diaebetes, Alloxan.

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