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Sottas, Chantal
- The Biology of Leydig Cell Development
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Authors
Affiliations
1 Center for Biomedical Research, Population Council, New York, NY 10021, US
2 Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine Auburn University, 109 Greene, Hall, Auburn, AL 36849, US
1 Center for Biomedical Research, Population Council, New York, NY 10021, US
2 Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine Auburn University, 109 Greene, Hall, Auburn, AL 36849, US
Source
Journal of Endocrinology and Reproduction, Vol 8, No 1&2 (2004), Pagination: 13-26Abstract
Greater understanding of the growth factor regulation of Leydig cells during their postnatal differentiation has been achieved. Increasingly, attention will shift toward the goal of isolating Leydig stem cells because of their therapeutic potential in the treatment of male hypogonadism and the syndrome of androgen deficiency of aging males (ADAM). Markers of Leydig stem cells such as Kit receptor can be exploited in harvesting enriched fractions from the testis for amplification in vitro. When subsequently implanted back into the same testis, we expect the amplified stem cells to undergo differentiation into steroidogenic Leydig cells.Keywords
Androgen Deficiency, Leydig Cell, Stem Cell, Steroidogenesis.- Modulation of the Male Reproductive Axis by an Environmental Antiandrogen Dl (2-Ethylhexyl) Phthalate
Abstract Views :321 |
PDF Views:0
Authors
Affiliations
1 Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, 109 Greene Hall, Auburn Univ AL 36849, US
2 Center for Biomedical Research, Population Council, New York, NY 10021, US
1 Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, 109 Greene Hall, Auburn Univ AL 36849, US
2 Center for Biomedical Research, Population Council, New York, NY 10021, US