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C. Maheswari ¹, R. Venkatnarayanan ², P. Babu ³, C. S. Kanadasamy ⁴

Affiliations
1 Department of Pharmacology, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, Tamilnadu, IN
2 Department of Pharmacognosy, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore, Tamilnadu, IN
3 Department of Pharmaceutical Chemistry, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore Tamilnadu, IN
4 Department of Pharmacognosy, R.V.S. College of Pharmaceutical Sciences, Sulur, Coimbatore Tamilnadu, IN

Abstract

Aim of this study was to evaluate the in vivo anti-snake venom activity of leaves of Orthosiphon stamineus were studied against Cobra (Naja Naja) venom. The in vivo study was carried out by using Swiss albino mice in modifying the lethal effect of the test dose of the Cobra venom. In in vivo model the effectiveness of the extract was evaluated by oral administration of two different doses (200 and 400 mg/kg) of the methanolic extract of the leaves of Orthosiphon stamineus 5 minutes prior to the injection of the venom and the percentage of mortality was observed. The extract markedly decreased the percentage of mortality in venom induced toxicity in mice at the dose of 400mg/kg b.w which indicates the significant anti-snake venom activity of the plant there by justifying its use in the indigenous system of medicine. The present study has confirmed the ethnomedical use of the plant for the treatment of snake bite.

Keywords

Snake venom, Naja Naja, Orthosiphon stamineus, Leaves, Mice.

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R. Suresh ¹, D. Benitojohnson ¹, C. Maheswari ¹, R. Venkatnarayanan ², R. Manavalan ³

Affiliations
1 Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
2 RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN
3 Department of Pharmaceutics, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore-641402, IN

Abstract

The chemopreventive potential was assessed by monitoring the tumour incidence, total no of tumours and tumour volume and also by analyzing the level of biochemical markers such as 17-β estradiol (E2), TBARS and antioxidants during DMBA induced mammary carcinoma. A single subcutaneous injection of DMBA (25mg/kg) produced mammary carcinoma in female Sprague-Dawley rats. Oral administration of 100mg/kg and 200mg/kg of TRM to DMBA treated rats significantly prevented the tumour incidence, total no of tumours, tumour volume and brought back the above said biochemical markers to normal. The present study confirmed the chemopreventive activity of leaves of Triumfetta rhomboidea in mammary carcinoma

Keywords

Mammary Carcinoma, Triumfetta rhomboidea, Leaves, DMBA, Antioxidants.

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R. Pavithra ¹, C. Maheswari ¹

Affiliations
1 Dept of EEE, Dr.N.G.P IT, Coimbatore, IN

Abstract

The work presented in this paper concerns the speed control of a switched reluctance motor (SRM) by use of a Maximum Power Point Tracking (MPPT) strategy applied to a SEPIC converter. A PV generator is used for energy supply. Fuzzy logic control has become an important methodology in many fields. This paper proposes a Fuzzy Logic Controller (FLC) to control the speed of SRM motor. The main objective of this work is to compare the operation of P& PI based conventional controller and gives the effective performance using Fuzzy Logic Control. The present work concentrates on the design of a fuzzy logic controller for the SRM speed control. Thus the result of applying fuzzy logic controller to a SRM drive gives the best performance and high robustness than a conventional P&PI controller. Simulation is carried out using Matlab simulink.

Keywords

Switched Reluctance Motor (SRM), Photovoltaic’s, MPPT Control, Sepic Converter, Fuzzy Logic Control.

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