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Gyana Kumari, C.
- Synthesis, Characterization, DNA Binding and Antimicrobial Activity of Copper (II) Complexes with 4-Aminoantipyrine Schiff Bases
Authors
1 Department of Chemistry, Osmania University, Hyderabad-500007, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 10 (2011), Pagination: 1529-1535Abstract
The Schiff bases namely 5-Me SALAAP, 3-OMe SALAAP, 3-Br, 5-Cl SALAAP have been prepared by reacting 4- amino antipyrine with 5-methyl salicylaldehyde/3-methoxy salicylaldeyde /3-Br, 5-Cl salicylaldehyde. The Cu(II) complexes have been prepared by reacting copper(II) chloride with those of Schiff bases in alcoholic medium .The complexes are non electrolytes in DMSO. These have been characterized by using elemental analysis, IR, UV-VIs, 1H, 13C NMR, Mass spectra, ESR spectra, Magnetic susceptibility, conductance measurements and thermal (TGA and DTA) anaylsis. The complexes were found to have composition ML2.On basis of elemental and spectral studies, six coordinated geometry is assigned for these complexes. The Schiff bases act as tridentate and coordinate through the azomethine nitrogen, carbonyl oxygen and phenolic oxygen respectively. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied by spectroscopic methods. The synthesized ligands and their metal complexes were screened against bacteria. (E.coli and Staphylococcus aureus). The activity data show that the metal complexes are more potent than Schiff bases.
Keywords
Schiff Bases, Aminoantipyrine, DNA Binding , Cu (II)Complexes, Microbial Activity.
- Synthesis, Spectral Characterization, Molecular Modeling and Antimicrobial Studies of Transition Metal Complexes and the Schiff Base Derived From 3-Formylchromone and Tryptamine
Authors
1 Department of Chemistry, Osmania University, Hyderabad, Andhra Pradesh-500 007, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 7 (2011), Pagination: 1043-1049Abstract
An attempt to find alternative ways of producing polymers from non-petroleum oil specifically, soybean oil, was A series of Cu(II) , Ni(II) , Co(II) , Mn(II) and Zn(II) complexes have been synthesized from the novel schiff base ligand L. The schiff base ligand 3-[(2-(1H-indole-3-yl)ethylimino)methyl]-4H-chromen-4-one (L) has been synthesized by the reaction between chromone-3-carbaldehyde and tryptamine. The nature of bonding and geometry of the transition metal complexes as well as schiff base ligand L have been deduced from elemental analysis, FT-IR, UV-Vis, 1HNMR, 13CNMR, ESR spectral studies, mass, thermal (TGA and DTA) analysis, magnetic susceptibility and molar conductance measurements. All the metal ions are forming 1:1(M:L) metal complexes. Based on elemental, conductance and spectral studies, six-coordinated geometry was assigned for Mn(II) and Co(II) complexes, fourcoordinated geometry was assigned for Cu(II), Ni(II) and Zn(II) complexes. Except cobalt complex remaining four metal ion complexes are neutral in DMSO, cobalt complex is 1:1 electrolyte. The ligand L acts as bidentate and coordinates through nitrogen atom of azomethine group and oxygen atom of keto group of γ-pyrone ring. The 3D molecular modeling and energies of all the compounds are furnished and their analysis for bond length has been carried out for one of the representive complexes. The biological activity of the ligand and its complexes have been studied on E.coli, and Edwardella by well disc and fusion method and found that some of the metal chelates are more active than the free schiff base ligand.