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- S. B. Patil
- G. M. Chavan
- D. S. Ghodke
- Nilofar S. Naikwade
- R. S. Ghodake
- N. S. Patole
- N. S. Naikwade
- Archana R. Dhole
- Giraja G. Shendage
- Shardha Pethkar
- S. K. Mohite
- Rohan Patil
- Neha Patil
- Aniket Patil
- S. J. Shid
- V. N. Dange
- A. B. Hajare
- M. M. Nitalikar
- V. V. Patil
- M. S. Kondawar
- Rohan R. Vakhariya
- Swati Talokar
- Swati Talolkar
- Vidya Dange
- Shubhangi Shid
- M. Y. Lende
- V. S. Thakur
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- Akshada Kakade
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- D. Raut Indrayani
- Gharge Manisha
- Dandwde Sonli
- Rutuja R. Shaha
- A. C. Patil
- A. R. Patil
Journals
- Research Journal of Pharmacology and Pharmacodynamics
- Asian Journal of Pharmacy and Technology
- Research Journal of Topical and Cosmetic Sciences
- Asian Journal of Pharmaceutical Analysis
- Asian Journal of Pharmaceutical Research
- Asian Journal of Research in Pharmaceutical Sciences
- Research Journal of Pharmaceutical Dosage Form and Technology
- Research Journal of Pharmacognosy and Phytochemistry
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Magdum, C. S.
- Screening of Some Indigenous Plants for Their Antipyretic Activity
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Authors
Affiliations
1 Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli-416 416, IN
1 Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli-416 416, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 143-144Abstract
In the present study, aqueous extract of leaves of Capparis zeylanica Linn, Annona reticulata Linn and Clerodendron phlomidis Linn were given at a dose of 200mg/kg, 400mg/kg (p.o.).
The antipyretic activity was done after inducing hyperpyrexia by injecting subcutaneously 20% aqueous suspension of Brewer's yeast in rats. Rats developing 0.5° C-1° C or more rises in rectal temperature 18 h after injection were taken for study.
The results proved that the aqueous extract of leaves of Clerodendron phlomidis Linn and Annona reticulata Linn has significant antipyretic activity and were compared with paracetamol (150 mg/kg body weight, p.o.), a standard antipyretic agent. Aqueous extract of leaves of Capparis zeylanica Linn has not reduced elevated fever in experimental rats.
Keywords
Capparis zeylanica Linn, Clerodendron phlomides Linn, Annona reticulata Linn, Antipyretic Activity.
References
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- Kritikar KR. and Basu BD. Indian medicinal plants. Vol.II. Lalit mohan Basu Prakashan, Allahabad. 1933.
- Nadkarni KM. Indian Materia medica, Popular Prakashan, Bombay. 1982.
- Loux JJ, Depalma PD, Yankell SL. Antipyretic testing of aspirin in rats, Toxicol Appl Pharmacol. 1972; 2: 672-5.
- Murugesan, T.,et al. Evaluation of Antipyretic potential of Jussiaea suffruticosa Linn. Extract in rat. Phytomedicine. 2000; 7(3): 231.
- Subrata K. et. al. Antipyretic activity of Eupatorium adenophorum leaf extract, Indian J. Nat. Prod. 2005; 21(1): 16-17.
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- In Vitro Anthelmintic Activity of Medicinal Plants against Pheretima posthuma
Abstract Views :445 |
PDF Views:2
Authors
Affiliations
1 Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli - Miraj Road, Sangli. 416416, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, IN
1 Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli - Miraj Road, Sangli. 416416, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 3 (2011), Pagination: 112-114Abstract
In this study, in vitro activity of were conducted to determine the possible anthelmintic activity of different solvent extracts like aqueous extract of leaves of cajanus cajan Linn, methanolic extract of leaves of vitex negundo Linn, Ethanolic extract of bark of Euphorbia tirucalli Linn and ethyl acetate extract of leaves of synadiium grantii Linn, methanolic extract of leaves of Euphorbia nerrifolia Linn against Indian worm Pheretima posthuma. With regard to effect of extract of Euphorbia tirucalli Linn, Euphorbia nerrifolia Linn, cajanus cajan Linn showed significant action on earthworm, vitex negundo Linn showed moderate activity. All the extracts were found not only to paralyse (vermifuse) but also death (vermicidal) except ethyl acetate extract of synadiumm graantii.Keywords
Anthelminitic Activity, Pheretima posthuma, Euphorbia nerrifolia Linn. Euphorbia tirucalli Linn, Synadiium grantii Linn, cajanus cajan Linn, vitex Negundo Linn.References
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- Ravishankar B, Bhaskaran NR, Sasikala CK. Pharmacological evaluation of Vitex negundo (Nirgundi) leaves. Bull Med Ethno Bot Res 1985; VI (1): 72–92.
- Gupta M, Mazumder UK, Bhawal SR. CNS activity of Vitexnegundo Linn in mice. Indian J Exp Biol 1999; 37; 143–146.
- Avadhoot Y, Rana AC. Hepatoprotective effect of Vitex negundo against carbon tetrachloride induced liver damage.Arch Pharm Res 1991; 14(1): 96–98.
- Nair AM and Saraf MN. Inhibition of antigen and compound 48/80 induced contraction of guinea pig trachea by ethanolic extract of the leaves of Vitex negundo Linn. Indian J Pharmacol 1995; 27: 230– 233.
- Kuvar SD and Bapat UC medicinal plant used by kokani tribals of nasik district Maharashtra to cure cuts and wounds. Indian journal of traditional knowledge VOL.9(1) , 2010, pp,144-115.
- Uma Shankar Sharma,In vitro anthelmintic activity of Murraya koenigii Linn leaves extract. International Journal of Pharma and Bio Sciences Vol.1 (3) 2010 pg no. 1-4.
- Drug used in Inflammatory Bowel Disease (IBD) - Brief Review
Abstract Views :262 |
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walva, Dist.-Sangli - 415 404, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walva, Dist.-Sangli - 415 404, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 3 (2014), Pagination: 153-161Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which includes Crohn's disease (CD) and ulcerative colitis (UC). These diseases have become important health problems. Medical therapy for IBD has advanced dramatically in the last decade with the introduction of targeted biologic therapies, the optimization of older therapies, including drugs such as immunomodulators and 5-aminosalicylic acid (5-ASA), and a better understanding of the mucosal immune system and the genetics involved in the pathogenesis of IBD. The goal of IBD therapy is to induce and maintain remission. Drug delivery to the appropriate site(s) along the gastrointestinal tract also has been a major challenge, and second-generation agents have been developed with improved drug delivery, increased efficacy, and decreased side effect The current treatment paradigm involves a step-up approach, moving to aggressive, powerful therapies only when milder therapies with fewer potential side effects fail or when patients declare themselves to have an aggressive disease. This review focuses on the, symptoms, diagnosis and current treatments for inflammatory bowel disease.Keywords
Inflammatory Bowel Disease (IBD), 5-Aminosalicylates, Corticosteroids, Infliximab, Herbal Drugs, Symptoms, Diagnosis.References
- Longstreth GF. Definition and classification of irritable bowel syndrome: current consensus and controversies. Gastroenterol. Clin. North Am. 2005; 34: 173-87.
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- WHO. International Statistical Classification of Diseases and Related Health Problems, 10th edn. Geneva, Switzerland: World Health Organization, 2007.
- Manning AP, Thompson WG, Heaton KW, Morris AF. Towards positive diagnosis of the irritable bowel. BMJ 1978; 2 (6138): 653-4.
- Brandt LJ, Bjorkman D, Fennerty MB et al. Systematic review on the management of irritable bowel syndrome in North America. Am. J. Gastroenterol. 2002; 97 (11 Suppl.): S7-26.
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- McClean, VA, USA: Degnon Associates, 2006. 7 Thompson WG, Irvine EJ, Pare P, Ferrazzi S, Rance L. Functional gastrointestinal disorders in Canada: first population-based survey using Rome II criteria with suggestions for improving the questionnaire. Dig. Dis. Sci. 2002; 47: 225-35.
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- Palsson OS, Drossman DA. Psychiatric and psychological dysfunction in irritable bowel syndrome and the role of psychological treatments. Gastroenterol. Clin. North Am. 2005; 34: 281-303.
- Cash BD, Chey WD. Irritable bowel syndrome-an evidence based approach to diagnosis. Aliment. Pharmacol. Ther. 2004; 19: 1235-45.
- Park JM, Choi MG, Kim YS et al. Quality of life of patients with irritable bowel syndrome in Korea. Qual. Life. Res. 2009; 18: 435-46.
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- Bommelaer G, Dorval E, Denis P et al. Prevalence of irritable bowel syndrome in the French population according to the Rome I criteria. Gastroenterol. Clin. Biol. 2002; 26: 1118-23.
- World Gastroenterology Organization, 2009 WGO Global Guideline IBD4
- Barnes PJ, Karin M: Nuclear factor-_B. A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med, 1997, 336, 1066-1071.
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- Preparation and Evaluation of Fast Dissolving Tablet Tramadol Hydrochloride
Abstract Views :163 |
PDF Views:4
Authors
Rohan Patil
1,
Neha Patil
1,
Aniket Patil
1,
S. J. Shid
1,
V. N. Dange
1,
C. S. Magdum
1,
S. K. Mohite
1
Affiliations
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 3 (2016), Pagination: 183-185Abstract
Novel drug delivery system assists to achieve better patient compliance. Fast dissolving tablets are one of them. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. FDDT formulation combines the advantage of both liquid and conventional tablet formulation while also offering advantage over both traditional dosage forms. This review gives a view of advantages, limitations, need for formulating FDTS, Formulation factors, excipients used, and methodology and evaluation parameters.
Fast dissolving tablets (FDTs) can be prepared by different methods, such as direct compression, freeze-drying, spray drying, sublimation, wet granulation method4. The basic approach for the development of FDTs is the use of superdisintegrants. The aim of this study was to formulate FDTs with sufficient mechanical integrity and to achieve faster disintegration in the oral cavity without water. To achieve this goal, mannitol used as diluent as well as sweetening agent for the formulation of tablets. Attempts were made to enhance dissolution rate along with faster disintegration using superdisintegrants, like microcrystalline cellulose. Tramadol hydrochloride, a centrally acting synthetic opioid analgesic, was selected as the active pharmaceutical ingredient in the study.
Keywords
Tramadol Hydrochloride, Direct Compression Method, Microcrystalline Cellulose.- Formulation and Optimization of Dermatological Dosage form for Comparative in-vitro Evaluation of Semisolid Bases
Abstract Views :259 |
PDF Views:0
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal- Walwa, Dist-Sangli, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Tal- Walwa, Dist-Sangli, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 7, No 2 (2016), Pagination: 46-54Abstract
The aim of this study was to improve the permeation of Diclofenac Sodium. Permeation studies were carried out in - vitro using cellophane membrane. Topical formulations of diclofenac sodium were prepared by using various polymers. Gel, cream and ointment of the drug were prepared with polymers and the formulations were subjected for evaluation. Gel formulations were containing carbopol 940, triethanolamine, and preservatives. Cream was formulated by using stearic acid, glycerin, lanolin and preservatives. Ointment was also formulated by using the ingredients cetostearyl alcohol, hard paraffin, white soft paraffin and wool fat. In-vitro permeation studies by using cellophane membrane in diffusion cell revealed better permeation characteristics of diclofenac sodium. These types of topical dosage forms could give sustained delivery of drug on to the skin, so they are interesting promises to improve skin absorption of non steroidal anti-inflammatory drugs and to prevent side effects associated. The Topical formulations are excellent in the percutaneous absorption of diclofenac or its salts and provide good properties upon use and superior medical effects of diclofenac or its salts.Keywords
Diclofenac Sodium, Gel, Cream, Ointment, Diffusion Cell.- Formulation of Gel and its UV Protective Study of Some Medicinal Flowers
Abstract Views :179 |
PDF Views:0
Authors
Affiliations
1 Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli – 416416, IN
2 Rajarambapu College of pharmacy, Kasegaon, Sangli, IN
1 Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli – 416416, IN
2 Rajarambapu College of pharmacy, Kasegaon, Sangli, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 2, No 2 (2011), Pagination: 64-65Abstract
The present study was designed to prepare sunscreen herbal formulations gel. Hibiscus rosa-sinesis L. (Malvaceae), Rosa Damascena (Rosaceae), Spathodea campanulata L. (Bignoniaceae) is one of the well-known drugs for its therapeutic values in traditional medicine. In the present study the drug was screened for its cosmetic use. All the three herbal drugs containing flavonoid showed sunscreen activity. The sunscreen activities of gel formulations could be related to the free radical scavenging properties of polyphenol compounds in the extracts incorporated in it. The method is performed by UV -visible spectrophotometry in the range of 200-400nm. Result of the extracts alone and gel formulation showed maximum absorbance at 270-300nm.Keywords
Hibiscus rosa-sinesis L,Rosa damascena, Spathodea campanulata L. Sunscreen Gel.- Comparative Standardization Study of Two Marketed Shatavari Churna Formulation
Abstract Views :220 |
PDF Views:1
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon. 415404, IN
1 Rajarambapu College of Pharmacy, Kasegaon. 415404, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 1 (2016), Pagination: 1-6Abstract
Majority of Ayurvedic practitioners uses traditional herbal preparations for their treatment purposes made by them. So it is necessary to improve safety of herbal drugs by developing certain quality control parameters and by following the WHO guidelines for herbal medicines. Our adulteration. Now days, old methods are necessary but there are lots of limitations to these methods due to shortage of many drugs, unavailability or limited source, adulteration, lack of knowledge of drug identification and adverse effects of drugs etc. Standardization of herbal formulation is essential in order to assess the quality of drugs for therapeutic value. The World Health Organization (WHO) in 1999 has given a detail protocol for the standardization of herbal drugs comprising of a single content, but very little literature is available for the standardization of Shatavari Churna. Two marketed preparations were used for the study. Performed the various parameters including organoleptic characteristics and physicochemical parameters. The set parameters were found to be sufficient to standardize the Shatavari Churna.Keywords
Traditional, Standardization, Shatavari Churna, Physicochemical Parameters.- OPLC- A Novel Technique
Abstract Views :219 |
PDF Views:2
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa Dist. Sangli-415,404 Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa Dist. Sangli-415,404 Maharashtra, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 3 (2015), Pagination: 161-167Abstract
OPLC is coming of age. Its rudimentary beginnings, some 25 years ago, have lead to innovative, highperformance products. The commercialization of modern, high efficiency columns has eliminated the need for analysts to prepare their own from TLC plates, making the technique even more accessible. Optimum performance laminar chromatography (OPLC) is a pumped flow chromatography technique that combines the user-friendly interface of HPLC with the capacity of flash chromatography and the multidimensionality of thinlayer chromatography. This review will describe the basis of modern OPLC instrumentation and the separation techniques, as well as give a brief account of some recent applications in OPLC.Keywords
OPLC, Instrumentation, Application.- A Review:Dry Emulsion
Abstract Views :298 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, IN
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 4 (2015), Pagination: 208-210Abstract
The dry Emulsion formulation aim to improve the bioavailability of drug substances and reduce their side effects. Dry Emulsions are attractive because they are physically and microbiologically stable formulations. They represent a potential oral drug delivery system for lipophilic and low soluble drug substances. Dry emulsions are prepared by drying liquid o/w emulsions containing a solid carrier in the aqueous phase. The solid carrier provides the dry emulsions with bulk and mass. Dry emulsions can be prepared by spray drying, lyophilization and rotary evaporation. Unfortunately the dry emulsions were cohesive powders. The cohesiveness are reduced by addition of sucrose. For preparing dry Emulsions the organic fillers used are Lactose, Mannitol, Malto-dextrins.Keywords
Dry Emulsion, Lipophilic Drugs, Solid Carriers etc.- Formulation of Gel and its UV Protective Study of Some Medicinal Flowers
Abstract Views :234 |
PDF Views:0
Authors
Affiliations
1 Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli – 416416, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, IN
1 Appasaheb Birnale College of Pharmacy, South Shivajinagar, Sangli – 416416, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 1, No 2 (2011), Pagination: 34-35Abstract
The present study was designed to prepare sunscreen herbal formulations gel. Hibiscus rosa-sinesis L. (Malvaceae), Rosa Damascena (Rosaceae), Spathodea campanulata L. (Bignoniaceae) is one of the well-known drugs for its therapeutic values in traditional medicine. In the present study the drug was screened for its cosmetic use. All the three herbal drugs containing flavonoid showed sunscreen activity. The sunscreen activities of gel formulations could be related to the free radical scavenging properties of polyphenol compounds in the extracts incorporated in it. The method is performed by UV -visible spectrophotometry in the range of 200-400nm. Result of the extracts alone and gel formulation showed maximum absorbance at 270-300nm.Keywords
Hibiscus rosa-sinesis L, Rosa damascena, Spathodea campanulata L., Sunscreen Gel.- Protective Effect From UV Rays by Medicinal Flowers
Abstract Views :158 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivaji nagar, Sangli ,Maharashtra – 416 416, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, IN
3 P.S.G.V.P. Mandal's College of Pharmacy, Shahada, Maharashtra, IN
1 Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivaji nagar, Sangli ,Maharashtra – 416 416, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, IN
3 P.S.G.V.P. Mandal's College of Pharmacy, Shahada, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 1 (2012), Pagination: 24-25Abstract
Sunscreen resources mostly obtained from plants in form of natural substances which are ability to absorb ultraviolet ray in the UVA region. This paper evaluates UV absorption ability of flowers from various varieties of Clitoria ternata Linn (Fabaceae), Canna indica Linn (Scitaminaceae), as an anti-solar agent. Extracts were prepared by maceration with a mixture of distilled water and methanol (1:1). The method is performed by UV spectrophotometer in the range of 200 to 400 nm and results of all the extracts shows effective UV absorption in the given range.Keywords
UV Protection, Clitoria ternata Linn, Canna indica Linn, Hydro-Alcoholic Extract.- A Review on Solid Lipid Nanoparticle
Abstract Views :266 |
PDF Views:4
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon Tal-Walwa, Dist Sangli–415 404, IN
1 Rajarambapu College of Pharmacy, Kasegaon Tal-Walwa, Dist Sangli–415 404, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 3 (2016), Pagination: 218-220Abstract
Solid lipid nanoparticles (SLN) are the emerging field of nanotechnology having many potential applications in drug delivery as well as in research. Lipid nanoparticles offer possibility to develop new therapeutics due to their unique size dependent properties. The ability of incorporating drug molecules into nanocarriers provides a new prototype in drug Delivery which could be used for drug targeting. Therefore solid lipid nanoparticles have great promise for increasing the goal of controlled and site specific drug delivery. Present review focus on broad treatment of solid lipid nanoparticles with their aims, production procedures, advantages, limitations and their possible remedies. SLN are sub-micron colloidal carriers ranging from 50 to 1000 nm, which are composed of physiological lipid, dispersed in water or in aqueous surfactant solution. Solid lipid nanoparticle offer unique properties such as very small size, large surface area, high drug loading and the interaction of phases at the interface and are attractive for their potential to increase performance of pharmaceuticals.- Potentials of Eulophia ochreata Lindl:A Review
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon-415404, IN
1 Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon-415404, IN
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Research Journal of Pharmacognosy and Phytochemistry, Vol 6, No 3 (2014), Pagination: 132-136Abstract
Medicines derived from plant extracts are being increasingly utilized to treat a wide variety of diseases, though relatively little knowledge about their mode of action is available. There is a growing interest in the pharmacological evaluation of various plants used in Indian traditional systems of medicine. Thus, the present review highlights the overview of Eulophia ochreata Lindl. It is an important medicinal plant from Orchidaceae family and it has diverse biological activity. It is used in traditional folk medicine system in most part of the mahatrastra district. Based on survey, herbs used for the review has well established histories of human use for the treatment of rheumatic and arthritic conditions. The present review article also highlights the properties, potential, therapeutic uses, pharmacological activity and research on Eulophia ochreata L. Hence, there is urgent need to utilize ancient knowledge of Eulophia ochreata L. to bring its maximum potential in the field of medical and pharmaceutical sciences in novel herbal drug development which will economically benefited for common man.Keywords
Eulophia ochreata Lindl, Orchidaceae, Survey, Amarkand, Anti-Inflammatory.- Anti-inflammatory Activity of Aqueous and DCM Extracts of Jatropha gossypifolia Linn in Albino Rats
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, IN
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Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 4 (2011), Pagination: 148-150Abstract
Medicinal herbs are the local heritage with global importance. World is endowed with a rich wealth of medicinal herbs. The different variety of plants with different therapeutic properties is quiet astonishing. Jatropha gossypifolia Linn (Euphorbiaceae) is a large genus of shrubs, herbs and trees distributed in the tropical parts of the world. A decoction of the bark is used as an emmenagogue, that of the leaves for stomach ache, venereal diseases and as blood purifier. The plant has been used ethnomedically to prevent cancerous growth. The plant is very popular in all Maharashtra and Jatropha gossypifolia Linn has suggested in the Indian system of medicine for number of diseases. The plant is known to possess various active agents such as flavonoids, triterpenoids, sterols (phytosterol), tannins, essential and volatile oils. The anti inflammatory activity of the aqueous and dichloromethane extract of the leaves of Jatropha gossypifolia Linn was investigated with experimental animal model using the carrageenan induced rat paw edema method. The extract 200mg/kg at 240min post treatment caused a significant (p<0.05) reduction in the paw oedema in rats. The effect of the extract was more pronounced at the dose 200mg/kg and was closer to that of ibuprofen 10mg/kg. The finding of the studies indicate that the aqueous extract and dichloromethane extract of leaves of Jatropha gossypifolia Linn had good anti-inflammatory activity in carrageenan induced hind paw edema in rats between 2 to 3 hours.
Keywords
Jatropha gossypifolia Linn, Euphorbiaceae, Antiinflammatory Activity, Carrageenan, Paw Edema.- Antimycobacterial and Antimicrobial Activity of Leaf Extracts of Vitex negundo Linn
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Authors
Affiliations
1 Appasaheb Birnale College of Pharmacy, South-Shivaji Nagar, Sangli-Miraj Road, Sangli, 416416(MS), IN
2 Appasaheb Birnale College of Pharmacy, south-Shivaji nagar, Sangli- Miraj Road, Sangli- 416416(MS), IN
3 Ashokrao Mane College of Pharmacy, Peth Vadgaon, (M.S.), IN
1 Appasaheb Birnale College of Pharmacy, South-Shivaji Nagar, Sangli-Miraj Road, Sangli, 416416(MS), IN
2 Appasaheb Birnale College of Pharmacy, south-Shivaji nagar, Sangli- Miraj Road, Sangli- 416416(MS), IN
3 Ashokrao Mane College of Pharmacy, Peth Vadgaon, (M.S.), IN
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Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 2 (2010), Pagination: 166-168Abstract
Vitex negundo belonging to the family verbanaceae has been reported to posses many medicinal properties according to indigenous system of medicine. The present work deals with antimycobacterial and antimicrobial activity of vitex negundo leaves. The different solvent extracts of the leaves prepared were studied for their antimycobacterial activity by Conventional proportion method and Nitrate reductase assay method. The activity was compared with standard drugs rifampicin and isoniazid. The ethanolic, successive ethanolic and methanolic extracts showed highest antitubercular activity, while petroleum ether extract and chloroform extract was moderately active as compared to other extracts of Nirgundi. Aqueous, benzene, acetone extract does not shows any antitubercular activity Antimicrobial activity of all extracts was screened by Paper Disc method against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. The benzene extract showed significant antimicrobial activity compared to petroleum ether and chloroform extract. Preliminary phytochemicals of all extracts were also investigated.
Conclusion: In conclusion nitrate reductase assay was found to be rapid, inexpensive and easy to perform. It also showed good concordance between conventional proportion method and nitrate reductase assay.
All these findings justified the claim made in the indigenous system of medicine for the use of the plant vitex negundo against tuberculosis and many other micro-organisms.
Keywords
Antimicrobial, Antitubercular, Nirgundi, NRA etc.- Evaluation of Total Phenolic Content, Flavonoid Content and Antioxidant Activity of Stem Bark of Careya arborea Roxb
Abstract Views :153 |
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Authors
K. A. Wadkar
1,
C. S. Magdum
2
Affiliations
1 Appasaheb Birnale College of Pharmacy, Sangli-416416, IN
2 Appasaheb Birnale College of Pharmacy, Sangli-416416, IN
1 Appasaheb Birnale College of Pharmacy, Sangli-416416, IN
2 Appasaheb Birnale College of Pharmacy, Sangli-416416, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 1 (2010), Pagination: 49-51Abstract
In this study we have determined the total phenolic, flavonoid content and antioxidant activity of pet. ether, aqueous and alcoholic extract of the stem bark of Careya arborea Roxb. (Lecythidaceae). Folin-ciocalteu method was used to determine the total phenolic content and flavonoid contents of these extract were assessed by aluminium chloride method. The antioxidant activities were determined by DPPH method. Aqueous extract and alcoholic extract showed presence of phenolic and flavonoid content and hence possessed greater antioxidant activity. Pet. ether extract containing very less amount of phenol and flavonoids, did not showed any antioxidant activity. The results suggest that the plant is good source of antioxidants and support their use in various diseases.Keywords
Careya arborea, Total Phenol, Flavonoids, Antioxidant.- Sun Protective Activity of the Hydroalchoholic Extracts of Two Medicinal Flowers
Abstract Views :150 |
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Authors
Affiliations
1 Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli-416416, Maharashtra, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, IN
3 SVERI’s College of Pharmacy, Pandharpur, Maharashtra, IN
1 Department of Pharmacology, Appasaheb Birnale College of Pharmacy, South Shivaji Nagar, Sangli-416416, Maharashtra, IN
2 Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, IN
3 SVERI’s College of Pharmacy, Pandharpur, Maharashtra, IN
Source
Asian Journal of Pharmaceutical Research, Vol 2, No 1 (2012), Pagination: 37-38Abstract
Sunscreens are chemicals that provide protection against the adverse effects of solar and in particular UV radiation. In this present study UV absorption ability of flowers evaluated from flowers of Thunburgia alata Linn, Abutilon indicum Linn. Extracts were prepared by maceration with a mixture of distilled water and methanol (1:1). The method is performed by UV spectrophotomety in the range of 200 to 400 nm and results of all the extracts shows effective UV absorption in the given range.Keywords
UV Protective, Thunburgia alata Linn, Abutilon indicum Linn, Hydroalcoholic.- A Review on Breast Cancer:An Overview
Abstract Views :335 |
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon Sangli-415404, IN
1 Rajarambapu College of Pharmacy, Kasegaon Sangli-415404, IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 1 (2017), Pagination: 49-51Abstract
Each year more than one million women are diagnosed with breast cancer worldwide over half of whom will die from the disease. Breast cancer is the most common cancer and the leading cause of cancer death for women. Extensive breast cancer screening programmes and the development of new treatments have improved the prognosis of breast cancer overall. However the average year survival rate for women with late stage or advanced breast cancer remains low. On average only 35% of women with advanced breast cancer are alive five years after diagnosis. A third of women are diagnosed with breast cancer at a late stage4 when the disease has a poor prognosis. Treatment options for breast cancer vary depending on the stage at which the cancer is diagnosed. Surgery and radiotherapy are commonly used to treat women with early stage breast cancer. Chemotherapy, hormonal and targeted therapies are frequently used to treat patients with more advanced forms of the disease.Keywords
Breast Cancer, Abnormal Cells, Stages, Diagnosis, Etc.- Formulation Development and Optimization of Simvastatin Loaded Solid Lipid Nanoparticles
Abstract Views :177 |
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 7, No 1 (2017), Pagination: 49-52Abstract
The present research work support preformulation, formulation, development and optimization of solid lipid nanoparticles containing simvastatin as an antihyperlipidemic drug. The different batches of formulation were obtained using simvastatin as active pharmaceutical ingredient, stearic acid as the source of lipid and β - cyclodextrin as a polymer. Solid lipid nanoparticles of simvastatin were prepared by precipitation method. The prepared formulations were evaluated for various parameters like Particle size, Percentage entrapment efficiency, Measurement of Zeta Potential, FTIR, in-vitro release study. The result was found to be within standard limit. FTIR study reports indicated that there was no interaction between Simvastatin and other excipients. Motic microscope shown that the nanoparticles size ranges from 100-550nm. Percent entrapment efficiency was between 61.40% - 92.30%. Based on the resultants of the entrapment and particle size of nanoparticles, formulation S6 was observed to be optimized formulation. The optimized formulation exhibited 63.75% cumulative drug release after 24 h. The optimized batch shows mean of zeta potential at -44.0 mV.Keywords
Antihyperlipidemic Drug, β–Cyclodextrin, Entrapment Efficiency, Zeta Potential, Motic Microscope.- Formulation and Characterization of fast Dissolving tablets of Perindopril
Abstract Views :174 |
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon MS, IN
1 Rajarambapu College of Pharmacy, Kasegaon MS, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 1 (2017), Pagination: 51-55Abstract
In this investigation fast dissolving tablets of perindopril were prepared using different superdisintegrants like sodium starch glycolate and crosspovidone by direct compression method. Fast dissolving drug delivery is fastest, safest, convenient and most economic method of drug delivery having the highest patient compliance and preferred over conventional tablets therefore it is currently the gold standard in the pharmaceutical industry. Formulations were evaluated for precompressional parameters bulk density, tapped density, cars index, angle of repose etc and postcompressional parameters like uniformity of weight, thickness, hardness, friability, drug content, wetting time, water absorption ratio, in vitro disintegration time and in vitro dissolution study. The formulation A1 to A3 contain increasing concentration of Sodium starch glycolate showed the increases dissolution rate of drug release from 92.75 to 98.25 in 15 min, whereas formulation B1 to B3 contain crosspovidone in increasing concentration also increases the drug release from 94.75 to 99.02 in 15 min. The drug release from FDTs increased with increasing concentration of superdisintegrants and was found to be highest with formulations containing Crosspovidone as compared to sodium starch glycolate.Keywords
Fast Dissolving, Perindopril, Superdisintegrants, Drug Release Etc.- Preparation of Novel Biocompatible Honey Hydrogel with Turmaric and Aloe vera
Abstract Views :272 |
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa, Dist Sangli, Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon. Tal-Walwa, Dist Sangli, Maharashtra, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 2 (2017), Pagination: 77-80Abstract
There is an ever-present need for non-allergenic antibacterial and antifungal wound dressing with a superior healing property for chronic ulcers. Among the entire modern wound healing dressings, hydrogel has a good capacity to donate moisture or absorb exudate and thereby providing a moist environment to facilitate wound healing process and at the same time protect the wound too. In the present study, povidne iodine loaded acrylamide based biocompatible biodegradable hydrogel dressings incorporating alginate, chitosan and gelatin showed good fluid absorbance capacity. The addition of honey showed improved tensile strength and moisture absorbance capacity of the hydrogel sponge. Addition of turmeric and aloe vera give additional wound healing properties. Chitosan and Alginate films with different Aloe vera contents (5, 15, 25 and 35%) and turmeric contents (5, 15, 25 and 35%) were prepared and its properties evaluated in terms of thickness, transparency, swelling behavior and in vitro degradation.Keywords
Chitosan, Hydrogel, Aloe vera, Turmeric.- Cognitive Disorders and its Herbal Remedies
Abstract Views :137 |
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Sangli, Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Sangli, Maharashtra, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 9, No 1 (2017), Pagination: 42-46Abstract
People with mild cognitive impairment have problems with memory, language, thinking or judgment that are greater than the cognitive changes associated with normal aging. Cognitive disorders can be objectively measured in cognitive tests, but the changes in cognitive abilities are usually not serious enough to interfere with daily life and independence. A person with cognitive impairment has an increased risk of developing Delirium, Dementia Alzheimer's disease and Amnesia, but some people with cognitive impairment remain stable and others show improved cognitive abilities over time. There is no proper cure for the cognitive disorders and much of the treatments available have been able to only delay the progression of the disorders or provide symptomatic relief for a short time period. Therefore there is need for a different approach to the treatment of these cognitive disorders. Different medicinal plants have been used since ancient times in the treatment of various cognitive disorders. Therefore pharmacological screening of medicinal plants may provide useful leads in the discovery of new drugs for the treatment of cognitive disorders. Variety of medicinal plants which can be used in cognitive enhancement is reviewed in this article. Phytochemical substances such as alkaloids, curcuminoids, triterpenoids and withenolides with pharmacological activities related to cognitive disorders treatment are discussed in this review.Keywords
Cognitive Disorders, Alzheimer’s Disease, Medicinal Plants, Cognitive Enhancement, Phytochemical Substances.- Formulation and Evaluation of Polyherbal Anti-Acne Gel
Abstract Views :2706 |
PDF Views:1
Authors
A. C. Patil
1,
A. R. Patil
1,
A. C. Patil
1,
S. J. Shid
1,
V. N. Dange
1,
C. S. Magdum
1,
S. K. Mohite
1
Affiliations
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 8, No 2 (2017), Pagination: 61-63Abstract
Acne is an infection of the skin, caused by changes in the sebaceous glands. The most common form of acne is called acne vulgaris, which means "common acne". The redness comes from the inflammation of the skin in response to the infection. One of the most common disorders found among youngsters usually 18-25 years of age is Acne. Acne vulgaris, which is a skin disorder of the pilosebaceous gland leads to the formation of inflammatory lesions, seborrhea etc. There is a remarkable demand of herbal formulations in the global market. Acne is a popular disorder among the teenagers which make them feel unappealing to look at and also a sort of inferior feel. They take many measures to avoid and cure acne. Plants are well known for their medicinal and cosmetic uses.Keywords
Acne, Neem, Nutmeg.References
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- Goulden Victoria. Guidelines for the management of acne vulgaris in adolescents. Pediatr. Drugs. 5(2003): 301-313.
- Gopal M.G, Farahana B, Dr. Kala Suhas Kulkarni, Effectiveness of Herbal Medication in treatment of Acne vulgaris- A pilot Study, The Indian Practioner; 2001, 54, 10, 723.
- R. S. Adnaik, D. A. Bhagwat, I. D. Raut, S. K. Mohite, C. S. Magdum, Laxative and Anthelmintic potential of cassia alata flower extract, Research Journal of Pharmacy and Technology. Vol-04, No.01, January 2011, 98-100.
- Kanlayavattanakul. M., Lourith N. Therapeutic agents and herbs in topical application for acne treatment. Int. J. Cosmetic Sci. 2011; 33:289-29.