Informatics Publishing Limited

B. V. V. S. Surya Kiran , Bishnupada Biswal ¹, G. Nagarjuna Reddy ¹, L. K. Kanthal ², N. Sridhar ³

Affiliations
1 KLR Pharmacy College, Paloncha, Khammam, Andhra Pradesh, IN
2 Koringa College of Pharmacy, Korangi-533 461, E.G. Dt., Andhra Pradesh, IN
3 Pydah College of Pharmacy, Patavala, E.G.Dt., Andhra Pradesh, IN

Abstract

Herbal medicine is having very old history. Plants are the typical manufacturers of complex drug molecules, which serve as a prototype to develop more effective and less toxic medicines. Helminth infections are distressing huge population in the world. These infections are contributing to the disorders like pneumonia, anaemia, eosinophilia and under nourishment. Anthelmintics are the drugs which expels the parasitic worms from the gastrointestinal tract by either paralyzing or killing the worms. So, there is a need of investigation of new anthelmintic molecules. Eichhornia crassipes belongs to the family Pontederiaceae, commonly known as "Water hyacinth" is selected as test drug based on ethno-botanical survey conducted in East Godavari Dist., Andhra Pradesh. In present study evaluation of anthelmintic activity of ischolar_main extracts was done by using adult Indian earth worm Pheritima posthuma. The above activity was carried out using the petroleum ether, ethanol extracts of different concentrations using piperazine citrate positive control and normal saline as negative control. Overall anthelmintic activity revealed that concentration dependent nature of extracts. The extract shows potent and significant anthelmintic activity as compared to the standards and it was investigated to be used as effective anthelmintic drug.

Keywords

Helminth Infections, Anthelmintics, Eichhornia crassipes, Pheritima posthuma, Petroleum Ether & Ethanol Extract

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B. V. V. S. Surya Kiran ¹, L. K. Kanthal ¹, Bishnupada Biswal ²

Affiliations
1 Koringa College of Pharmacy, Korangi-533 461, E.G. Dt., Andhra Pradesh, IN
2 KLR College of Pharmacy, Paloncha, Khammam, Andhra Pradesh, IN

Abstract

Rheumatic heart disease (RHD) remains a major contributor to morbidity and mortality in developing countries. In the present study, cross-sectional survey is designed to determine the prevalence of RHD in children from private and public schools between the age of 5 and 15 years in urban and rural areas of East Godavari District of Andhra Pradesh using both cardiac auscultation and echocardiographic evaluation. This study describes a comprehensive approach to implement echocardiographic screening in a high prevalence region as recommended by the WHO and outlines a robust analysis plan to investigate clinical outcome with secondary prevention for subclinical RHD. Even though the population attributable risk of RHD is expected to be high, false-positive screening results may occur. In order to reduce false-positive findings, all echocardiographic clips with borderline or definite RHD will be assessed from two independent cardiologists. Moreover, screening in a large population of schoolchildren might yield in exceptional cases important incidental clinical findings unrelated to RHD but yet relevant for future prognosis (i.e., bicuspid aortic valve, atrial-septal defect).Prospective clinical studies investigating the impact of secondary prevention for subclinical RHD on long-term clinical outcome will be of central relevance for future health resource utilization in developing countries.

Keywords

Rheumatic Heart Disease, Cross-Sectional Survey, Echocardiographic Evaluation, WHO, School Children.

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