Informatics Publishing Limited

Pandu R. Vundavilli ¹, Ch. Swetha ¹, B. Swathi ¹, K. M. V. Ravi Teja ¹, K. Pratap ¹, T. V. Ranganath ¹

Affiliations
1 Department of Mechanical Engineering, DVR & Dr. HS MIC College of Technology, Kanchikacherla, Andhra Pradesh-521180, IN

Abstract

The present paper deals with the modelling of Abrasive water jet machining (AWJM) process using Fuzzy Logic (FL). It is important to note that the performance of AWJM in terms of required depth of cut in machining depends on various parameters, such as diameter of focusing nozzle, water pressure, abrasive mass flow rate and jet traverse speed. It is to be noted that the performance of the FL system depends on its knowledge base (that is, data base and rule base). The present paper deals with the development of two different approaches. The first approach deals with the development of knowledge base based on the human expertise. The second approach deals with the optimization of data base and rule base using genetic algorithms (GA). This approach will eliminate the need for extensive experimental work to select the most influential AWJM parameters on the depth of cut. The performances of the developed FL-based models have been tested on a number of test cases for predicting the required depth of cut for AWJM process. The prediction accuracy of the FL-based models is found to be satisfactory.

Keywords

Abrasive Water Jet Machining, Fuzzy Logic, Knowledge Base, Genetic Algorithms.

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S. Swathi ¹, B. Swathi ², Kasireddy Swapna ¹, G. Venkateshwarlu ¹, B. Swathi ², N. Sharada ¹, P. Laxmi ¹

Affiliations
1 Venkateshwara Institute of Pharmaceutical Sciences, Cherlapally, Nalgonda, Telangana, IN
2 Department of Pharmacy, Palamuru University, Mahabubnagar, Telangana, IN

Abstract

Now a day's peoples are completely habituated for cool life or without hard work so this reason causes many diseases. Recently most of the software employees yield for spondilysis, gastritis, heart stroke, brain stroke and paralysis etc. especially throughout world youth suffering with stress condition and money earning pressure and restless work, mechanical life also causes various diseases. Recently in Nalgonda one survey held on brain stroke and kidney failure, paralysis. In that survey as a pharmacist and other doctors are conducted for every 100 persons participated in that 7 members are heart stroke, 5 persons are kidney failure, 3 are paralyzed persons are there. This survey carried at Government hospital, Gollguda, Nalgonda, Telangana. why this ailments are raising means lack of exercise, fast food eating, environmental pollution, restless life, insomnia, companies task pressure on employ along with lot of reasons are there.

Keywords

Heart Stroke, Kidney Failure, Paralysis, Disease Survey.

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A. D. Pani Kumar ¹, G. Sunitha ¹, Y. Venkat Raju ¹, K. Rama Krishna ¹, B. Swathi ¹, CH. Praveen ¹, Swetha Mora ¹

Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Gokaraju Rangaraju College of Pharmacy, Hyderabad, Andhra Pradesh, IN

Abstract

Hydrotropy is one of the solubilizing techniques to enhance the solubility of poorly water soluble drugs. In the present investigation, hydrotropic solution of sodium citrate (0.1M) was employed as solubilizing agent to solubilize the poorly water soluble drug Naproxen fine powder and its tablet dosage form for spectrophotometric determination in UV region. Naproxen shows maximum absorbance at 330 nm and follows Beer's law in concentration range of 20-140 mcg/mL. Results of analysis were statistically validated for the linearity, precision, LOD, and LOQ. The proposed method is new, simple, accurate, reliable, more economic and can be successfully employed in routine to analyze Naproxen tablets. Either hydrotropic agent or commonly used tablet additives did not interference in analysis. The percentage recovery was within the range between 99 and 100.

Keywords

Sodium Citrate, Naproxen, Spectrophotometric.

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N. M. Vageesh ¹, Ramya Sri Sura ², K. Gulijar Begum ², B. Swathi ²

Affiliations
1 St. Johns College of Pharmaceutical Sciences, Yerakota, Yemmiganur, Kurnool (Dist), Andhra Pradesh, IN
2 Department of Pharmaceutics, Osmania University, Hyderabad, IN

Abstract

In the present research work gastro retentive floating matrix formulation of Lafutidine by using various polymers were developed. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent sodium bicarbonate concentration was optimized. Then the formulation was developed by using different concentrations of polymers Xanthan gum, guar gum and Sodium Alginate as polymeric substances. The formulation blend was subjected to various preformualation studies, flow properties and all the formulations were found to be good indicating that the powder blend has good flow properties. Among all the formulations Only Xanthan gum, Sodium Alginate highest concentrations (60 mg) retards the drug release upto 12 hours and the drug release 96. 25%, 95. 81% respectively. In this Xanthan gum releases the more drug release when compared to Sodium alginate. So F3 Formulation considered as optimized formulation. Optimised formulation F3 was kept for release kinetic studies. From the above graphs, it was evident that the formulation F3 was followed the Peppas release mechanism.

Keywords

Lafutidine, Xanthan Gum, Guar Gum and Sodium Alginate, Floating Tablets.

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