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Shrivastava, B.
- Pharmacognostical, Physico-Chemical and Phyto-Chemical Standardization of Cichorium intybus L. seed
Authors
1 Radharaman College of Pharmacy, Bhadbada Road, Ratibad, Bhopal- 462 002, Madhya Pradesh, IN
2 Radharaman College of Pharmacy, Fatehpur Dobra, Ratibad, Bhopal, Madhya Pradesh, IN
3 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 5, No 3 (2013), Pagination: 133-138Abstract
Alternative and traditional medicines, largely herbal in nature, are now regarded as important but underutilized tools against disease. WHO recognized this fact and encouraged governments to effectively utilize local knowledge of herbal medicines for disease prevention and health promotion. Herbal medicines, however, suffer from a range of shortcomings. These include insufficient and unacceptable evidences of safety, efficacy, standardization and inconsistent production practices. There is a growing concern for documentation of research work carried out on traditional medicines needed for regulatory control. With this backdrop, it becomes extremely important to make an effort towards standardization of plant material used for therapeutic purposes. The process of standardization can be achieved by stepwise pharmacognostical, phyto- and physico-chemical studies and minimizing the inherent variation of natural product composition through quality assurance practices. WHO recommends various physicochemical and phyto-chemical evaluation parameters for standardization and quality control of herbal medicinal plants. In view of ethnopharmacological importance of Cichorium intybus Linn, preliminary phyto-chemical screening and quantitative estimation of seed were performed along with morphology and microscopy to establish the salient diagnostic characters. The characteristics evaluated will be helpful for establishing quantitative and qualitative standardization of herbal preparations containing Cichorium intybus seed.Keywords
Cichorium intybus Seed, Pharmacognostical, Physicochemical, Phyto-Chemical Studies.- Preparation and Evaluation of Inclusion Complexes Using Cyclodextrins and Its Derivatives
Authors
1 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, IN
2 Bhagwan College of Pharmacy, Aurangabad, IN
3 Veerayatan Institute of Pharmacy, Bhuj, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 5, No 1 (2012), Pagination: 131-135Abstract
Domperidone is a widely used antiemetic, poorly water soluble drug, erratically absorbed in stomach and possess several dissolution related problems thus it has poor bioavailability. Solubility of a drug plays a very important role in dissolution and hence absorption of drug which ultimately affects its bioavailability. Hence, by considering the facts related to drug, attempts have been made to formulate inclusion complexes using various derivative of cyclodextrins.
Inclusion complexes were prepared using methylated betacyclodextrin and hydroxy propyl betacyclodextrin in 1:1 and 1:2 molar ratios. Kneading, ultrasonification and physical mixture method were used for preparation of inclusion complexes. The solubility and dissolution results revealed that there was an increase in solubility and dissolution of all inclusion complexes as compared to pure drug but was highest in case of methylated betacyclodextrin in 1:1molar ratio using ultrasonification method(USM1) and with hydroxypropyl betacyclodextrin in 1:2 molar ratio using ultrasonification method(USHP2).
Keywords
Cyclodextrins , Inclusion Complex.- Preparation and Evaluation of Anti-Inflammatory Transdermal Drug Delivery System
Authors
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur- 425201, IN
2 B.N.B.Swaminarayan College of Pharmacy, Vapi, Gujrat, IN
3 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon (M.S.), IN
4 Veerayatan Institute of Pharmacy, Bhuj, Gujrat, IN
5 School of Pharmaceutical Sciences, Jaipur National University, Jaipur, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 5 (2011), Pagination: 791-794Abstract
An abundance of the anti-inflammatory drugs are available for use in current medicine which have an established use in the treatment of arthritis and other painful conditions, amongst them one of the novel drug is Aceclofenac. Gels are an excellent formulation for several routes of administration such as oral, topical, nasal, vaginal, and rectal. Gel can be clear formulations when all of the particles completely dissolve in the dispersing medium. But this doesn't occur in all gels, and some are therefore turbid. This need has emphasized the importance of developing a topical dosage form of such drugs.
Aceclofenac is novel non steroidal anti-inflammatory drug which have proven its effectiveness in many of painful diseased conditions like osteoarthritis, rheumatoid arthritis, spondylitis etc. Like other NSAIDs it is also associated with adverse effects, majority of them are of gastrointestinal system (dyspepsia, abdominal pain, nausea and diarrhea). Present study was undertaken to develop an effective and stable topical formulations of Aceclofenac gel.