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Arirudran, B.
- Ameliorative Role of Threshold Level of Bilirubin in Newborn Jaundice and Efficacy of Noni Fruit Extract on Phenyl Hydrazine Induced Jaundice Rat
Authors
1 Department of Bio-Chemistry, S.R.M. Arts and Science College, Kattankulathur-603203, IN
2 Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 4 (2011), Pagination: 196-201Abstract
The aims of the present work were to elucidate the role of bilirubin as a free radical scavenger in unconjugated hyperbilirubinemic newborns. Bilirubin above an optimum level is toxic to human systems and is extcreted in urinary and through gastrointestinal tract. It is observed that serum bilirubin up to 85μ mole/l (5mg/dl) has a free radical scavenger activity and exceeding 200μmole/l (12mg/dl) is highly pro-oxidant. Phototherapy is the accepted therapeutic management of jaundiced newborns and has been shown to augment the oxidative stress. The ethanolic extract of Noni fruit administered orally at a dose of 3mg/ml is found to diminish the oxidative stress in erythrocytes of phenylhydrazine–induced unconjugated hyperbilirubinemic jaundiced rats, treated with phototherapy, which ultimately reduces the bilirubin level without inducing additional damages.Keywords
Bilirubin, Free Radical Scavenger, Pro-Oxidant, Phototherapy, Jaundice, Oxidative Stress, Noni.References
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- Clinical Evaluation to Assess the Efficacy of Ethanolic Extract of Avocado Fruit on Diabetic Dyslipidemia Studied in STZ- Induced Experimental Albino Rats
Authors
1 P.G. Department of Biochemistry, SRM College of Arts and Science, Chennai, IN
2 Department of Biochemistry, KMG College of Arts and Science, Gudiyattam, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 7 (2011), Pagination: 1131-1136Abstract
In Diabetes mellitus, the insulin defect reflects in elevated gluconeogenic metabolite accumulation, which leads to excess acetyl Co-A storage, and, in turn, the acetyl Co-A acts as a precursor of lipids directly, and lipoprotein indirectly, synthesis. Thus, hyperlipidemia is an associated complication of diabetes mellitus. Recently, we have reported that ethanolic extract of Persea americana lowered the blood glucose and oxidative stress in diabetic rats. In this present study, the hypolipidemic effect of Persea americana fruit was investigated in streptozotocin-induced diabetic rats. Oral administration of fruit extract (300 mg/kg b.w.) for 30 days resulted in significant reduction in serum and tissue cholesterol, triglycerides, phospholipids and free fatty acids in STZ-diabetic rats. In addition to that, significant decrease in high density lipoprotein while significant increase in low density lipoprotein and very low density lipoprotein, were observed in diabetic rats, which were brought to near normal after 30 days of herbal extract treatment. The results obtained are comparable with glyclazide, a standard drug. Results of the present study indicate that the fruits of Avocado showed antihyperlipidemic effect in addition to its antidiabetic and free radical scavenging activity properties in type 2 diabetic rats.
Keywords
Avocado, Acetyl Co-A, Hyperlipidemia, Lipoproteins, Gluconeogenic, Persea americana.- Antimicrobial Effect of Separate Extract of Acetone, Ethyl Acetate, Methanol and Aqueous from Leaf of Milkweed (Calotropis gigantea L.)
Authors
1 P.G. Department of Biochemistry, SRM Arts and Science College, Kattankulathur-603203, Kanchipuram District, Tamil Nadu, IN
2 Universiti Sultan Zainal Abidin, Kampus Kota, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, MY
Source
Asian Journal of Pharmaceutical Research, Vol 1, No 4 (2011), Pagination: 102-107Abstract
Objective: The present communication attempts to study the antimicrobial activity of leaf of Calotropis gigantea L. Methods: The leaf is subjected to various extraction using acetone, ethyl acetate, methanol and aqueous solvents against different bacterial and fungal organisms using disc diffusion method. Result: The acetone, ethyl acetate, methanol and aqueous extracts were active against all the samples and showed significant antibacterial properties. The methanol, acetone, ethyl acetate and aqueous extracts exhibited less activity against fungal organisms. Conclusion: Thus it may be suggested that leaf extracts of Calotropis gigantea L. may be used to treat oral bacterial diseases.
Keywords
Calotropis gigantea L, Antimicrobial Activity, Disc Diffusion Method.- Phytochemcial Analysis and Isolation, Identification of Bioactive Compounds Present in Root of Borassus flabellifer Linn. using GC/MS
Authors
1 P.G. Department of Biochemistry, SRM Arts and Science College, Kattankulathur, Kanchipuram, Tamil Nadu – 603203, IN
2 Upgraded Primary Health Centre Pudur, Uthamanur, Tiruchirappalli District, Tamil Nadu – 621712, IN
Source
Journal of Natural Remedies, Vol 22, No 4 (2022), Pagination: 705-716Abstract
Medicinal plants play a vital role in the health of humans and animals. Indians provide more importance and curiosity in cultivating medicinal plants. Borassus flabellifer Linn. is one among the plants that belong to the Araceae family, it is well known as the Palmyra palm is a native of tropical Africa but cultivated and naturalized throughout India. Traditionally different parts of this plant such as roots, leaves, fruit and seeds have been used for various human ailments, and the leaves of this tree are used to make mats, baskets, fans, toys, candy boxes and sulagu, etc. Aim: Most of the works have been studied from different parts of this tree like wood, stem, leaf, flower, fruits, pulp and petioles but the root has not been studied much yet, so this current research task is to focus on the isolation, identification and applications of bioactive compounds from the roots of Borassus flabellifer Linn. Standard methods were performed for preliminary phytochemical analysis. GC/MS was used to identify and isolate the bioactive components. Preliminary phytochemical analysis reveals that the roots of Borassus flabellifer Linn. comprise carbohydrates, terpenoids, flavonoids, coumarins, alkaloids, tannins, saponins, cardiac glycosides and proteins. GC/MS analysis reveals that ethanolic extracts from the roots of Borassus flabellifer Linn. are reported to have thirty-six bioactive compounds, and each compound has a unique significance. The result of this research work concludes and illustrates that the roots of Borassus flabellifer Linn. are rich in essential dietary nutrients, phytochemicals, and bioactive compounds that can be used for health-promoting benefits. Furthermore, a comprehensive and systematic approach is required to identify and understand the maximum potential for the benefit of mankind.Keywords
Bioactive Compounds, Borassus flabellifer, D-Mannose, GC/MS, n-Hexadecanoic Acid, Octadecanoic Acid, Phenol, 2,4-bis(1,1-dimethylethyl), Roots, Traditional Uses.References
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