A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Anilkumar, B.
- Hepatotoxicity Studies in the Progeny of Pregnant Dams Treated With Methimazole, Monocrotophos and Lead Acetate
Authors
1 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad - 500 030, IN
2 Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad - 500 03, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 18, No 1 (2011), Pagination: 67-69Abstract
An experimental study was conducted to evaluate the hepatotoxic effects in the progeny of dams treated with methimazole, monocrotophos (MCP) and lead acetate. Female pregnant albino rats of Wistar Kyoto strain were divided into five groups and treated as follows, from day 3 of pregnancy till weaning of pups on postnatal day (PND) 21. Group 1 served as sham control, group 2 received methimazole 0.02% in drinking water, group 3 received MCP (0.3 mg/kg orally), group 4 received lead acetate at 0.2% in drinking water and group 5 received MCP + lead acetate. Thyroid hormone profile was recorded on 14th day of gestation in dams. Eight pups from each group were euthanized on PND 21 and 90, and liver tissues were collected for analysis. Thiobarbituric acid reactive substances (TBARS), protein carbonyls and reduced glutathione (GSH) of liver were studied on PND 21 and 90, while the activities of Na+/K+ ATPase and Mg2+ATPase in the liver were studied on PND 90. T3, T4, GSH, Na+/K+ ATPase and Mg2+ATPase were significantly (P<0.05) decreased, while TBARS and protein carbonyls were significantly (P<0.05) increased in all the test groups as compared to group 1. From this study, it is concluded that both MCP and lead acetate have a possible influence on thyroid gland of dams as the thyroid profile was altered significantly and the hepatotoxic effects were comparable to those induced by methimazole.Keywords
Hepatotoxicity, lead acetate, methimazole, monocrotophos, rats- Sero-biochemical Studies in Sheep Fed with Bt Cotton Plants
Authors
1 Departments of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
2 Veterinary Pathology, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
3 Livestock Research Institute, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
4 Department of Animal Nutrition, College of Veterinary Science, Hyderabad, Andhra Pradesh, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 17, No 2 (2010), Pagination: 99-101Abstract
An experimental study was conducted to evaluate the toxicological effects, if any, due to feeding of Bt (Bacillus thuringiensis) cotton plants to sheep. A total of 32 sheep of one year of age belonging to Deccani breed were randomly divided into four groups, consisting of eight sheep in each group. Group 1 was maintained on basal diet (concentrate feed at the rate of 300 g + green fodder at the rate of 3 kg/sheep/day), group 2 on non-Bt cotton plant at the rate of 1.5 kg + green fodder at the rate of 1.5 kg + concentrate feed at the rate of 300 g/ sheep/day, group 3 on Bt cotton plants (50%) at the rate of 1.5 kg + green fodder at the rate of 1.5 + concentrate feed at the rate of 300 g/sheep/day, and group 4 on Bt cotton plants ad libitum + concentrate feed at the rate of 300 g/sheep/day. All the groups of sheep were maintained for three months and various hemato-biochemical parameters were studied at monthly intervals. The activity of aspartate transaminase, gamma glutamyltransferase, and creatine kinase in sera samples, and the concentration of blood urea nitrogen and creatinine did not differ significantly among different groups at different time intervals. The histological examination of liver and kidney did not reveal any significant changes in Bt and non-Bt cotton-fed groups. In conclusion, the results of the present investigation enunciated that feeding of genetically modified (Bt) cotton plants to sheep was without detrimental effects in the biological system of sheep.Keywords
Bt cotton, sero-biochemistry, sheep- Cadmium and Chlorpyrifos Induced Lipid Peroxidation in Brain, Liver and Kidney of Wistar Rats
Authors
1 Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, IN
2 Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Korutla, Jagtial District – 505326, Telangana, IN
3 Controller of Examinations, PVNRTVU, Administrative Office, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, IN
4 Department of Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Mamnoor, Warangal District – 506166 , Telangana, IN
5 Department of Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 29, No 4 (2022), Pagination: 475-480Abstract
The work was designed with 4 groups for 28 days. 1: Control. 2: CdCl2 @ 22.5mg/ kg b.wt / oral. 3: CPF @ 25 mg/ kg b.wt /per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Higher mean values of liver, kidney and brain TBARS were observed in G-2, 3 and 4 on 15th and 29th day. Liver section in group 2 revealed mild degenerative changes in group 3; in group 4 mild to moderate peri portal fibrosis. Kidney section in group 2 showed shrunken glomeruli, necrosis; kidney section showed degeneration and necrosis of tubular epithelium with casts in the lumen in group 3 and necrosis with casts in the lumen in group 4. Brain section in group 2 showed mild perivascular cuffing, mild to moderate degeneration of Purkinji cells in group 3 and in group 4 degeneration of Purkinje cells. Effects in G-4 were severe than individual groups due to synergistic action of the combined pollutants than the individual effects.
Keywords
Cadmium, Chlorpyrifos, Lipid Peroxidation, Wistar Rats.References
- Ravikumar Y, Madhuri D, Lakshman M, Reddy AG, Kalakumar B. Study of Cadmium and Chlorpyrifos Induced Changes in Protein and Lipid Profile in Rats. Toxicology International. 2020 Jun 1;27(1&2):54-7.
- Belyaeva EA, Dymkowska D, Wi?ckowski MR, Wojtczak L. Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells. Toxicology and Applied pharmacology. 2008 Aug 15;231(1):34-42.
- Bjørling-Poulsen M, Andersen HR, Grandjean P. Potential developmental neurotoxicity of pesticides used in Europe. Environmental Health. 2008 Dec;7(1):1-22.
- Yadala RK, Madhuri D, Lakshman M, Gopalareddy A, Kalakumar B, Anilkumar B, Sawale GK, Lakshmi Namratha M. Pathological alterations in the spleen induced by cadmium and chlorpyriphos in male Wistar rats.Journal of Entomology and Zoology Studies, 2020, 8(4): 2180-2183.
- Ambali SF, Orieji C, Abubakar WO, Shittu M, Kawu MU. Ameliorative effect of vitamin C on alterations in thyroid hormones concentrations induced by subchronic coadministration of chlorpyrifos and lead in wistar rats. Journal of Thyroid Research. 2011, 1:6
- Yadala Ravikumar MD, Lakshman M, Gopalareddy A, Kalakumar B, Anilkumar B, Sawale GK, Sandhyarani K, Ramesh J. Cadmium and Chlorpyrifos induced histopathological alterations in the heart of male rats. The Pharma Innovation Journal. 2020;9(9):18-20.
- Balasubramanian KA, Manohar M, Mathan VI. An unidentified inhibitor of lipid peroxidation in intestinal mucosa. Biochimica et Biophysica Acta (BBA)-Lipids and Lipid Metabolism. 1988 Sep 2;962(1):51-8.
- Luna GLHT. Manual of Histological and Special Staining Techniques, 2nd Edition. The Blakiston Divison McGraw-Hill Book Company, Inc. New York, Toronto, London. 1968 9:34.
- Snedecor GW. Cochran. WG Statistical Methods. Ames, Iowa: Iowa State University Press, chapt. 1967;12:339-80.
- Renugadevi J, Prabu SM. Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Experimental and Toxicologic Pathology. 2010 Mar 1;62(2):171-81.
- Prabu SM, Muthumani M, Shagirtha K. Protective effect of Piper betle leaf extract against cadmium-induced oxidative stress and hepatic dysfunction in rats. Saudi journal of biological sciences. 2012 Apr 1;19(2):229-39.
- Imafidon CE, Risikat OT, Samuel BF, Esther OO, Aderonke AK. Cadmium-induced testicular toxicity, oxidative stress and histopathology in Wistar rats: sustained effects of polyphenol-rich extract of Vernonia amygdalina (Del.) leaf. Journal of Interdisciplinary Histopathology. 2016 Jun 23;4(3):54-62.
- Paules M, Zaher J, Hafez E, El-Tahawy N. Toxicological Effects Induced by Chlorpyrifos Administration on Thyroid and Suprarenal Glands in Adult Male Albino Rats. Ain Shams Journal of Forensic Medicine and Clinical Toxicology. 2013 Jan 1;20(1):99-105.
- Hassani S, Sepand MR, Jafari A, Jaafari J, Rezaee R, Zeinali M, Tavakoli F, Razavi-Azarkhiavi K. Protective effects of curcumin and vitamin E against chlorpyrifos-induced lung oxidative damage. Human & experimental toxicology. 2015 Jun;34(6):668-76.
- Deng Y, Zhang Y, Lu Y, Zhao Y, Ren H. Hepatotoxicity and nephrotoxicity induced by the chlorpyrifos and chlorpyrifos-methyl metabolite, 3, 5, 6-trichloro-2-pyridinol, in orally exposed mice. Science of the Total Environment. 2016 Feb 15;544:507-14.
- Dudley RE, Gammal LM, Klaassen CD. Cadmium-induced hepatic and renal injury in chronically exposed rats: likely role of hepatic cadmium-metallothionein in nephrotoxicity. Toxicology and applied pharmacology. 1985 Mar 15;77(3):414-26.
- Sudo JI, Hayashi T, Kimura SI, Kakuno K, Terui J, Takashima K, Soyama M. Mechanism of nephrotoxicity induced by repeated administration of cadmium chloride in rats. Journal of toxicology and environmental health. 1996 Jul 1;48(4):333-48.
- Renugadevi J, Prabu SM. Naringenin protects against cadmium-induced oxidative renal dysfunction in rats. Toxicology. 2009 Feb 4;256(1-2):128-34.
- Savithri Y, Sekhar PR, Doss PJ. Biochemical and histopathological changes in liver due to chlorpyrifos toxicity in albino rats. J Ind Soc Toxicol. 2010;6:5-10.
- Singh R, Srivastava AK, Gangwar NK, Giri DK, Singh R, Kumar R. Pathology of sub-chronic cadmium and chlorpyrifos toxicity in broilers.Indian Journal of Veterinary Pathology. 2016, 40(4): 331-336. https://doi.org/10.5958/0973-970X.2016.00076.6