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Audumbar Digambar Mali ¹, Ritesh Bathe ¹

Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN

Abstract

Microsponges are polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles with a large porous surface. Moreover, they may enhance stability, reduce side effects and modify drug release favorably. Microsponge technology has many favorable characteristics, which make it a versatile drug delivery vehicle. Microsponge Systems are based on microscopic, polymer-based microspheres that can suspend or entrap a wide variety of substances, and can then be incorporated into a formulated product such as a gel, cream, liquid or powder. Microsponge and Nanosponge delivery System was originally developed for topical delivery of drugs can also be used for controlled oral delivery of drugs using water soluble and bioerodible polymers. Microsponge delivery system (MDS) can entrap wide range of drugs and then release them onto the skin over a time by difussion mechanism to the skin. It is a unique technology for the controlled release of topical agents and consists of nano or micro porous beads loaded with active agent and also use for oral delivery of drugs using bioerodible polymers.

Keywords

Microsponges, Controlled Release, Porous Microspheres, Nanosponge, Solvent Diffusion Method, Quasi-Emulsion Method.

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Audumbar Digambar Mali ¹

Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN

Abstract

Derivative spectrophotometry offers a useful approach for the analysis of drugs in multi-component formulation. In this study a second order derivative spectrophotometric method is applied for the simultaneous determination of Carvedilol and Hydrochlorothiazide in tablet dosage form. The measurements were carried out at wavelengths of 292 and 272 nm for Carvedilol and Hydrochlorothiazide respectively. The method was found to be linear (r²=0.999) in the range of 5-25 μg/ml for Carvedilol in the presence of 20 μg/ml of Hydrochlorothiazide at 292 nm. The linear correlation (r²=0.999) was obtained in the range of 5-25 μg/ml for Hydrochlorothiazide in the presence of 20 μg/ml of Carvedilol at 272 nm. The method was successfully used for simultaneous determination of Carvedilol and Hydrochlorothiazide in tablet dosage form without any interference from excipients and prior separation.

Keywords

Carvedilol, Hydrochlorothiazide, Uv Visible Spectrophotometry, Method Validation, Accuracy, Pricission, Second Order Derivative Method.

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Audumbar Digambar Mali ¹, Patil Manoj kumar ¹

Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN

Abstract

Simple, fast and reliable spectrophotometric methods were developed for determination of Ranitidine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol. The quantitative determination of the drug was carried out using the first order Derivative Area under Curve method values measured at 329-335nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Ranitidine using 2-10μg/ml (r²=0.999) for first order Derivative Area under Curve spectrophotometric method. The proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Ranitidine in pharmaceutical formulations.

Keywords

Ranitidine, First Order Derivative, Area under Curve (AUC).

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Audumbar Digambar Mali ¹, Manojkumar Patil ¹

Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur MS, IN

Abstract

Simple, fast and reliable spectrophotometric methods were developed for determination of Levocetirizine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol. The quantitative determination of the drug was carried out using the second order Derivative Area under Curve method values measured at 247-255nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Levocetirizine using 5-25μg/ml (r^²=0.999) for second order Derivative Area under Curve spectrophotometric method. The proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Levocetirizine in pharmaceutical formulations.

Keywords

Levocetirizine, Second Order Derivative, Area under Curve (AUC), Precision, Accuracy.

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Audumbar Digambar Mali ¹, Ritesh Bathe ¹, Ashpak Tamboli ²

Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN
2 Department of Pharmaceutical Chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN

Abstract

Simple, fast and reliable spectrophotometry methods were developed for determination of Domperidonein bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 286nm and the area under the curve method values measured at 279-293 nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Domperidone using 5-25μg/ml (r²=0.999 and r²=0.998) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Domperidonein tablets.

Keywords

Domperidone, UV Visible Spectrophotometry, AUC, Method Validation, Precission, Accuracy.

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Audumbar Digambar Mali ¹, Ritesh Suresh Bathe ¹

Affiliations
1 Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, IN

Abstract

The purpose of this review on microballoons is to accumulate the recent literature with special focus on the recent development on floatation to achieve gastric retention. Microballoons are emerging as the most promising drug delivery as it overcome many limitations of conventional drug delivery system. As microballoons delivery system provides longer retention in gastric pH, hence longer is the residence time and therefore enhance the solubility of drugs that are less soluble in high pH environment. The formation of cavity inside the microsphere depends upon the preparation temperature and the surface smoothness determines the floatability and the drug release rate of the microballoons.

Keywords

Microballoons, Gastroretentive, Bioavailability, Sustained Effect, Oral Administration.

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