Informatics Publishing Limited

Ghanshyam B. Jadhav ¹, Amar G. Zalte ¹, Ravindranath B. Saudagar ¹, Ashok P. Pingale ²

Affiliations
1 KCT’s R. G. Sapkal College of Pharmacy, Anjaneri, Tal-Trimbakeshwar, Dist- Nashik, Maharashtra, IN
2 Dept. of Pharmaceutical Chemistry, M.V.P's College of Pharmacy, Gangapur Road, Nashik, Maharashtra, IN

Abstract

A simple, accurate, precise, sensitive and a highly selective ultra violet spectrophotometric method has been developed for the simultaneous estimation of in bulk and solid dosage form. The estimation of Zidovudine was carried out at 266 nm. The developed method was validated for linearity, range, precision, recovery studies and interference study for mixture. All these parameters showed the adaptability of the method for the quality control analysis of the drug in bulk and in marketed formulations.

Keywords

Zidovudine, UV- Method, Spectrometric Method, Determination.

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Ashok P. Pingale ¹, A. R. Rote ², R. B. Saudagar ³, Rima R. Patil ², G. B. Jadhav ³

Affiliations
1 Department of Pharmaceutical Chemistry, MVP College of Pharmacy, University of Pune, Maharashtra, Nashik 422002, IN
2 Department of Pharmaceutical Chemistry, M.G.V’s Pharmacy College (Pune University), Mumbai, IN
3 KCT’s R. G. Sapkal College of Pharmacy, Anjineri, Nashik, Maharashtra, IN

Abstract

Spectrophotometric method were proposed for the simultaneous analysis of Drotaverine HCl and Nimesulide in a tablet formulationby absorbance ratio method at 278 nm (isoabsorptive point) and 304 nm(λ max of Drotaverine HCl ) with mean percentage recovery 98.25%±0.66 and 100.5%±0.95, respectively. Beer's law for both methods was obeyed in the concentration range 5-25μg/ml of drotaverine HCl and Nimesulide respectively. The suggested method were successfully applied for the analysis of the two drugs in their pharmaceutical formulation. The obtained results were statistically agreed with those obtained by the reported method.

Keywords

Drotaverine HCl, Nimesulide, Absorbance Ratio Method.

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