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Subramanian, Aruna Priyadarshni
- Natural Frequency of Cancer Cells as a Starting Point in Cancer Treatment
Abstract Views :1503 |
PDF Views:186
Authors
Saravana Kumar Jaganathan
1,
Aruna Priyadarshni Subramanian
1,
Muthu Vignesh Vellayappan
1,
Arunpandian Balaji
1,
Agnes Aruna John
1,
Ashok Kumar Jaganathan
2,
Eko Supriyanto
1
Affiliations
1 IJN-UTM Cardiovascular Engineering Centre, Universiti Teknologi Malaysia, Johor Bahru 81310, MY
2 Research and Development Wing, AVTEC Ltd, CK Birla Group, Hosur 635 114, IN
1 IJN-UTM Cardiovascular Engineering Centre, Universiti Teknologi Malaysia, Johor Bahru 81310, MY
2 Research and Development Wing, AVTEC Ltd, CK Birla Group, Hosur 635 114, IN
Source
Current Science, Vol 110, No 9 (2016), Pagination: 1828-1832Abstract
Breast cancer and prostate cancer are the most common gender-specific types of cancer among women and men respectively, around the world. The most preferred treatment embraced by the patients is chemotherapy. The anticancer drugs developed and used so far cannot completely cure cancer at all stages and also exhibit some side effects in the patients who undergo chemotherapy. Besides this, some cancer cells eventually acquire resistance to many drugs and evade the treatment procedures. All these factors play a vital role in persuading the researches to find alternative modes of treatment for cancer. This communication proposes an unconventional mode of cancer treatment by determining the natural frequencies of normal and cancer cells. By utilizing these frequencies, it is possible to kill the cancer cells specifically, sparing the healthy cells. The normal and cancer cells in case of breast (MCF-10A, MCF-7) as well as prostate cancer (BPH, LNCap) are modelled as a sphere in ANSYS. The modal analysis is done in order to obtain their natural frequencies along with their mode shapes at different frequencies. The results show that the natural frequency of the normal cells is much higher than that of the cancer cells at each corresponding mode. The natural frequency is proportional to the mechanical properties of the cells and is insignificant with respect to the change in diameter of the cells. Thus, utilizing the natural frequency, cancer cells may be specifically targeted while the burdens of chemotherapy and drug resistance.Keywords
Breast Cancer, Modal Analysis, Natural Frequency, Prostate Cancer.References
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