Informatics Publishing Limited

Vivek B Rajendra ¹, Dinesh L. Dhamecha ¹, Amit A. Rathi ¹, Maria Saifee ¹, Swaroop R. Lahoti ¹, Mohd. Hassan G Dehghan ¹

Affiliations
1 Y.B.Chavan College of Pharmacy, Dr. Rafiq Zakaria campus, Aurangabad-431001, Maharashtra, IN

Abstract

Transdermal delivery of drugs through the skin to the systemic circulation provides a convenient route of administration for a variety of clinical indications. For transdermal delivery of drugs, stratum corneum is the main barrier layer for permeation of drug. This physicochemical constraint severely limits the number of molecules that can be considered as realistic candidates for transdermal delivery. Iontophoresis provides a mechanism to enhance the penetration of hydrophilic and charged molecules across the skin. This technique facilitates movement of ions across a membrane under the influence of an externally applied electric potential difference. The present reviews discuss the basic principle, mechanism, factors affecting and combination strategies of iontophoresis.

Keywords

Transdermal, Iontophoresis, Electroporation, Sonophoresis.

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Dinesh l. Dhamecha ¹, Amit A. Rathi ², Maria Saifee ², Swaroop R. Lahoti ², Mohd. Hassan G Dehghan ²

Affiliations
1 Y.B.Chavan College of Pharmacy, Dr. Rafiq Zakaria campus, Maulana Azad Education Trust, Rauza Bagh, Aurangabad-431001, Maharashtra, IN
2 Y.B.Chavan College of Pharmacy, Dr. Rafiq Zakaria campus, Maulana Azad Education Trust, Rauza Bagh, Aurangabad-431001, Maharashtra, IN

Abstract

Recently many drugs are formulated as floating drug delivery systems with an objective to sustain the release of drug in stomach. Ranitidine hydrochloride, which is better absorbed in stomach and whose site of action is gastric area was formulated as floating matrix tablet using gas generating agent (sodium bicarbonate, citric acid) and polymers like HPMC K4M and polaxomer. Formulation was optimized on the basis of in vitro release. All other parameters like physical parameters like thickness and hardness were within range. In vitro buoyancy was found to be in the range of 17 to 89 seconds and water uptake in the range of 125 to 280 %. Floating time was more than 24 hrs. In vitro drug release of the optimized batch was found to be 88% at the end of 8th hr. Hence, it is evident from this investigation that this gas powered floating matrix tablet could be promising delivery system of Ranitidine hydrochloride with sustained release action and improved drug availability at target area.

Keywords

Floating Matrix Tablet, Ranitidine Hydrochloride, In Vitro Release.

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