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Vyas, Amber
- Importance of Pharmacovigilance in Indian Pharmaceutical Industry
Authors
1 Columbia Institute of Pharmacy, Raipur (C.G.), IN
2 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 2, No 1 (2012), Pagination: 4-8Abstract
Pharmacovigilance is the pharmacological science relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term and short term side effects of medicines. It is the science of collecting, monitoring, researching, assessing and evaluating information from healthcare providers and patients on the adverse effects of medications, biological products, herbalism and traditional medicines with a view to:
Identifying new information about hazards associated with medicines Preventing harm to patients.
Phase IV of the evaluation of a drug starts when the marketing license is granted and extends over many years. It consists of pharmacoepidemiological studies to evaluate the effectiveness, safety, and utilization of the drug in large populations, under real-life conditions. The results confirm or disprove the effectiveness of the drug in clinical practice (confirmation of the therapeutic effect), determine whether approved uses should be expanded or restricted, any untoward interactions (pharmacovigilance) and pharmacoeconomics of the drugs.
- Development of fingerprinting method for Siddha formulation Nilaavaarai chooranam: A HPTLC approach
Authors
1 Chhattisgarh Food and Drug Administration, Mahasamund (CG)., IN
2 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.)., IN
3 Institute of Pharmacy, Vikram University, Ujjain (MP)., IN
Source
Asian Journal of Research in Chemistry, Vol 15, No 5 (2022), Pagination: 327 - 330Abstract
Selective and efficient analytical methods are required not only for quality assurance but also for authentication of herbal formulations. Fingerprint method for Nilaavaarai Chooranam with TLC Densitometric Methods (HPTLC) using piperine as an internal standard was developed. The HPTLC estimation was carried out with three laboratory batches and one marketed formulation of Nilaavaarai Chooranam and crude drug containing piperine. The concentration of piperine present in raw material was found to be 2.9836±0.497w/w in Piper nigrum and in three identical laboratory batch of Nilaavaarai Chooranam NC-I, NC-II and N-III, was found to be 0.1761 ± 0.384, 0.1759 ± 0.534%, 0.1760 ± 0.019 w/w respectively. The piperine content in all the three different batches is found to be in close proximities with each other. The results were comparable to marketed formulations. Hence the present method is simple, sensitive, precise and accurate and can be adopted for routine fingerprinting method for quality control of Nilaavaarai Chooranam.Keywords
Nilaavaarai chooranam, Piperine, Sidhha formulation, HPTLC, Standardization.References
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