Informatics Publishing Limited

Alok Singh ¹, Lovely Lakhmani Balani ², Brijesh Kumar Pandey ²

Affiliations
1 Thakur Institute of Management Studies, Career Development and Research, IN
2 Thakur Institute of Management Studies, Career Development and Research, IN

Abstract

Penetration testing is a method to assess and evaluate the security of computer network, website and application software. Penetration testing is a legal and authorized method to assess and secure a computer network. Through this paper we intend to introduce systematic and integrated approach to Web Application Penetration Testing. Nowadays most of the software applications are provided on web platform. Web applications increased accessibility and availability of software and services however it increases risk of malicious attacks. In order to provide quality software services web applications providers need to assess potential vulnerabilities and remove these potential weaknesses in their system to make it more secure from potential attackers. Pen tester applies various approaches to assess strength and weaknesses of a computer system. In this paper we discuss various steps involved in penetration testing such as information gathering, vulnerability analysis, exploitation and test analysis phase. We also discuss various automated tools available to a Pen Tester and their applications. Comparative vulnerability analysis is also provided on the basis of various Assessment parameters such as exploit ability, prevalence, detect ability and impact.

Keywords

Penetration Testing, Web Applications, Vulnerability Analysis, CMS, Backtrack5, Owsap, IPS/IDS, Web Crawlers Etc.

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Manar W. Jan ¹, Alok Singh ¹, Jishnu Naskar ¹

Affiliations
1 Department of Molecular and Cellular Engineering, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad (U.P.), IN

Abstract

Catharanthus roseus L. (Madagascar periwinkle) is regarded as a rich source of pharmaceutically important terpenoid indole alkaloids(TIAs) which are valued highly due to their wide spectrum of pharmaceutical application. Among these, vinblastine and vincristine are of particular importance because of their wide use in cancer chemotherapy. Vinblastine can have extensive use for the treatment of lung cancer, breast cancer, head and neck cancer and testicular cancer. It is also used to treat Langerhens cell histocytosis. This study was done to assess the stability of vinblastine. The extracted crude vinblastine was formulated with nanoparticles at different temperature. Stability was determined at varying temperature. Reduction method was used to synthesize silver nanoparticles, LDH was synthesized using co-precipitation method and MMT was purchased from Sigma-Aldrich.LDH and MMT formulated vinblastine showed maximum temperature stability at 60oC and 80oC. The increase in heat stability will help in increasing the shelf-life as well as storage at room temperature, eliminating the need for refrigeration. Study shows that formulation of NP-TIA’s has significant potential in drug delivery and enhanced shelf-life and storage condition.

Keywords

Catharanthus roseus, Terpenoid Indole Alkaloid, Vinblastine, Silver Nanoparticles, LDH, MMT.

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Alok Singh ¹, Manar W. Jan ¹, Jishnu Naskar ¹

Affiliations
1 Department of Molecular and Cellular Engineering, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad (U.P.), IN

Abstract

Catharanthus roseus (Madagascar periwinkle) is an ornamental plant belonging to the Apocynaceae family. Besides its importance as an ornamental plant, its interest today is centered on its capacity to biosynthesize a great variety of terpenoid indole alkaloids (TIAs) which are valued highly due to their wide spectrum of pharmaceutical application. Among these, vinblastine and vincristine are of particular importance because of their wide use in cancer chemotherapy. Vinblastine can have extensive use for the treatment of lung cancer, breast cancer, head and neck cancer, and testicular cancer. It is also used to treat Langerhens cell histocytosis.This study was done to assess the solubility of vinblastine. The extracted crude vinblastine was encapsulated with nanoparticles and solubility was determined at different pH range. Silver Nanoparticles was synthesized using reduction method, LDH was synthesized by Co-precipitation method while MMT was purchased from Sigma-Aldrich. Silver NP formulation showed maximum solubility at pH 10.4 and least at pH 6. In case of Layered Double Hydroxide (LDH) Nanoparticles and Montmorillonite nanoparticles (MMT) maximum solubility was obtained at pH 7 and pH 8.6, respectively. The increased solubility range of the drug with various nanoparticles formulation will enhance the bioavailability of the drug at physiological pH.This study shows that formulation of NP-TIA's has significant potential in the field of chemotherapy and drug delivery.

Keywords

Catharanthus roseus, Terpenoid Indole Alkaloid, Vinblastine, Silver Nanoparticles, LDH, MMT.

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Nayuta Takemori ¹, Alok Singh ²

Affiliations
1 Center for Emergent Matter Science, RIKEN, Wako, Saitama 351-0198, JP
2 Research Center for Structural Materials, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki 305-0043, JP

Abstract

A publication in Physical Review Letters by Shechtman et al. in 1984 announcing the discovery of a new and unusual quasiperiodic atomic order in solids led to excitement in the scientific community, especially among mathematicians, physicists, crystallographers and materials scientists. It resulted in a race to describe the structure of quasicrystals, development of higher dimensional crystallography, prediction of its properties and potential applications.

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Rita Devi ¹, Vicky Soni ¹, Savej Malik ¹, Alok Singh ¹, Kundan Banjare ¹, Vikram Singh ¹, Tanuja Janghel ¹, Pooja Pal ¹, Mukta Agrawal ¹, D. K. Tripathi ¹, Ajazuddin ¹, Amit Alexander ¹

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, 490024, IN

Abstract

Recent technological and scientific research has been devoted to the development of rate controlled drug delivery systems to overcome physiological adversities such as short gastric residence times and unpredictable gastric emptying times. The floating or hydro-dynamically controlled drug delivery systems are useful in such application. The objective of our review is to compile the recent advancements and developments regarding the novel dosage form i.e. the floating drug delivery systems (FDDS) that can be retained in the stomach for a prolonged period of time and gives therapeutic action in a predetermined manner. In these review article,the various aspects of pharmaceutical floating drug delivery system(FDDS) were compiled together and the target ordinance are specifically the M. Pharm and B Pharm students so that their knowledge towards the subject concern can be enhanced and also at the same time can be motivated towards the publication.

Keywords

Gastric Retention, Oral Controlled Release System, Gastric Resistance, Emptying Time, FDDS.

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Alok Singh ¹, Umesh Ghanekar ¹, Chakresh Kumar ², Ghanendra Kumar ³

Affiliations
1 NIT, Kurukshetra, Haryana, IN
2 ISM, Dhanbad, IN
3 Sharda University, IN

Abstract

An efficient two stage morphological impulse noise detector is proposed in this paper. The proposed method first identifies the noise pixels by comparing the current pixel with the brightest and the darkest pixels in its working window and then in second stage morphological operations based detector is used to improve the performance of impulse noise detector. Simulation results performed on different images shows better results in terms of the qualitative and quantitative measures of the images.

Keywords

Mathematical Morphology, Salt-and-Pepper Noise, Image Filter.

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K. K. Pant ¹, Vinit Kumar ¹, Bhaskar Biswas ¹, Arvind Kumar ¹, Shankar Lal ¹, Sona Chandran ¹, Saket Kumar Gupta ¹, Md. Khursheed ², Pravin Nerpagar ¹, A. K. Sarkar ¹, Ravi Kumar Pandit ¹, K. Ruwali ³, K. Sreeramulu ³, S. Das ³, R. S. Shinde ³, S. Chouksey ⁴, J. K. Parate ⁴, Viraj Bhanage ⁵, P. P. Deshpande ⁵, Shradha Tiwari ⁵, Mandar Joshi ⁶, Lalita Jain ⁵, Anand Valecha ⁷, Ayukt Pathak ⁵, M. A. Ali ⁵, H. R. Bundel ⁵, Purushottam Shrivastava ⁸, T. Reghu ⁸, Umesh Kale ⁸, Yashwant Wanmode ⁸, Praveen Mohania ⁸, Jaikishan Mulchandani ⁸, Akhil Patel ⁸, Mahesh Acharya ⁸, Ashish Mahawar ⁸, Mahendra Lad ⁹, M. K. Jain ⁹, Nitesh Tiwari ⁹, Pritam S. Bagduwal ⁹, V. G. Sathe ¹⁰, Sujata Joshi ¹⁰, Ram Shiroman ¹⁰, A. S. Yadav ¹⁰, Randhir Kumar ¹⁰, Alok Singh ¹¹, Vineet K. Dwivedi ¹¹, Mangesh Borage ¹², S. R. Tiwari ¹¹

Affiliations
1 Materials and Advanced Accelerator Sciences Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN
2 Advanced Lasers and Optics Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN
3 Accelerator Magnet Technology Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN
4 Design and Manufacturing Technology Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN
5 Laser Controls and Instrumentation Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN
6 Laser and Plasma Technology Division, Bhabha Atomic Research Centre, Mumbai 400 085, IN
7 Accelerator Control Systems Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN
8 Pulsed High Power Microwave Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN
9 Radio Frequency Systems Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN
10 Ultra-High Vacuum Technology Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN
11 Power Converters Division, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN
12 Homi Bhabha National Institute, Raja Ramanna Centre for Advanced Technology, Indore 452 013, IN

Abstract

An Infrared Free Electron Laser (IR-FEL) designed to operate in the 12.5–50 μm wavelength band is presently in an advanced stage of commissioning at the Raja Ramanna Centre for Advanced Technology (RRCAT), Indore. Here we report results from first experiments on the IR-FEL after installation of its optical cavity, which has resulted in a power output that is ~105 times the expected spontaneous emission power for the beam parameters used in the experiment. The estimated out-coupled peak micro-pulse power during these experiments is ~2 kW. This is the first observed signature of lasing in the IR-FEL, and the first reported lasing in a FEL in India. This communication discusses the development of the IR-FEL, the recent experimental results, and the ongoing efforts to further increase the IR power to the design peak out-coupled power of 2 MW.

Keywords

Beam Parameters, Free Electron Laser, Infrared Power, Undulator.

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