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Alimuddin Saifi ¹, Rajani Chauhan ², J. Dwivedi ³

Affiliations
1 Department of Pharmacognosy, NKBR College of Pharmacy & Research Centre, Meerut, IN
2 Department of Pharmacy, Banasthali University, Rajasthan, IN
3 Department of Chemistry, Banasthali University, Rajasthan, IN

Abstract

Ficus bengalensis is an indigenous plant belonging to family Moraceae possessing varied pharmacological properties like antidiabetic, antimicrobial, antioxidant, antiseptic, gonorrhea and also tender ends of hanging ischolar_mains are prescribed to stop vomiting. Herbal preparations of Ficus bengalensis had been considered as effective, economical and safe ethnomedicines for various ailments in Indian traditional system of medicine. All parts of plant are acrid, sweetish, astringent to the bowls; useful in "kapha" biliousness, ulcer, erysipelas, vomiting, vaginal complaints, fever and inflammation. The leaves are good for ulcers; the young leaves are good for ulcers; the young leaves are efficacious to cure leprosy. The milk juice is aphrodisiac, tonic, vulnary, maturant, lessens inflammation, useful to treat piles, diseases of the nose and gonorrhoea. The aerial ischolar_mains is styptic, aphrodisiac, and utilized to manage gonorrhoea, syphilis, biliousness, dysentery and inflammation of the liver. The leaves are vulnerary, useful is biliousness. Bark is tonic, astringent, cooling and hypoglycemic.

Keywords

Ficus bengalensis, Antidiabetic, Moraceae, Stem Bark, Bar.

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Alimuddin Saifi ¹, Rajani Chauhan ², Jaya Dwivedi ³

Affiliations
1 Dept. of Pharmacognosy, NKBR College of Pharmacy and Research Centre, Meerut (U.P.), IN
2 Dept. of Pharmacy, Banasthali University, Rajasthan, IN
3 Dept. of Chemistry, Banasthali University, Rajasthan, IN

Abstract

Background: Syzygium cumini (Linn.) Skeels belonging to family Myrtaceae have been documented to elicit hypoglycemic activity. Herbal preparations of Syzygium cumini have been considered as safe, effective and economical for various ailments in Indian traditional system of medicine. Its seed extract is used for the treatment of diabetes. The present study was undertaken to evaluate the hypoglycemic potential and effect on various biochemical parameters of 70 % v/v hydro-alcoholic extract of seeds of Syzygium cumini (SCE) in alloxan induced diabetic rats. Materials and method: Albino Wister male rats of weighing between 150 to 200 gms were used for the study. Diabetes was induced by injecting alloxan (120 mg/kg, i.p.). Rats were divided into different groups for the study. Group I served as normal control, Group II served as diabetic control, Group III served as standard control and treated by Tolbutamide at a dose of 100 mg/kg p.o. Group IV served as diabetic rats treated with hydro-alcoholic extract of seeds of Syzygium cumini at a dosage of 500 mg/kg body weight. All the treatments were given for 21 days. At the end of study on 21 day over night fasted rats were sacrificed and blood was collected to determine fasting blood glucose and biochemical findings. Result: Diabetic rats treated with SCE at a dose of 500 mg/kg significantly (P<0.01) reduced fasting blood glucose and normalize the lipid profile, renal profile and hepatic profile. Improvement in the histopathology of pancreas and liver of SCE treated rats confirmed its protective role in diabetes. Conclusion: It can be concluded that SCE possess antidiabetic activity and may be beneficial in improving complications associated with diabetes mellitus.

Keywords

Antidiabetic Activity, Syzygium cumini, SCE, Seed Extract, Alloxan-Induced Diabetes.

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Alimuddin Saifi ¹, Rajani Chauhan ², Jaya Dwivedi ³

Affiliations
1 Dept. of Pharmacognosy, NKBR College of Pharmacy and Research Centre, Meerut (U.P.), IN
2 Dept. of Pharmacy, Banasthali University, Rajasthan, IN
3 Dept. of Chemistry, Banasthali University, Rajasthan, IN

Abstract

Background: Medicinal plants have curative properties due to the presence of various complex chemical substance of different composition, which are found as secondary plant metabolites in one or more parts of these plants. Herbal formulation treatment can significantly alter the pattern of glucose tolerance in normal and diabetic rats. It is possible that herbal formulation may act through both, pancreatic and extra pancreatic mechanism(s). In present study the polyherbal formulation (FMST) was developed by mixing the hydroalcoholic extracts of the stem barks of Ficus bengalensis (FBE), fruits of Momordica charantia (MCE) and seeds of Trigonella foenum graecum (TGE) and Syzygium cumini (SCE) in optimized ratio. The aim of this work was to establish the dose response relationship of the individual and combined herbal extracts. Further it was aimed to optimize the dose of the formulation to produce the required effect. The antidiabetic activity was determined in normal and diabetic rats respectively. In the hypoglycemic study of individual extracts, the optimum doses were found to be 120, 300, 1000 and 500 mg/kg b.w, p.o/day, of extracts of FB, MC, TG and SC respectively. The optimized doses were further evaluated for antidiabetic activity in alloxan induced diabetic rats. Based on the above optimized doses, a polyherbal formulation was prepared by mixing the extracts in the ratio of 1.2:3:10:5. Materials and method: Albino Wister male rats of weighing between 150 to 200 gms used for the study. Diabetes was induced by injecting alloxan (120 mg/kg, i.p.). Group I served as normal control, Group II served as diabetic control, Group III served as standard control and treated by Tolbutamide 100 mg/kg p.o. Group IV, V and VI served as diabetic rats treated with FMST at different dosage of 200 mg/kg (FMST-2), 400 mg/kg (FMST-4) and 600 mg/kg (FMST-6) for the purpose of dose optimization and to find out the most effective and safer dose. All the treatments were given for 21 days. At the end of study on 21 day over night fasted rats were sacrificed and blood was collected to determine fasting blood glucose and biochemical findings. Result: The dose response relationship of the formulation was observed as per the evaluation of antidiabetic activity. The combined herbal extract exhibited synergistic effect, and was better than any of the extracts. The initiation of the effect was early and the duration was increased with the combination. Diabetic rats treated with FMST-2, FMST-4 and FMST-6 significantly (P<0.01) reduced fasting blood glucose and normalize the lipid profile, renal profile and hepatic profile. Improvement in the histopathology of pancreas and liver of FMST-4 treated rats confirmed its protective role in alloxan induced diabetes. Conclusion: It can be concluded that FMST-2, FMST-4 and FMST-6 possess antidiabetic activity. FMST-4 was found to be optimum and may be beneficial improving complications associated with diabetes mellitus. From the above, it may be concluded that polyherbal formulation exhibited superior desired activity because of their combined individual activities. The study provides scientific support for their claimed activity in Ayurveda.

Keywords

Antidiabetic Activity, FMST-2, FMST-4, FMST-6, Alloxan-Induced Diabetes.

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Aarti Bhati ¹, Sanjeev Kumar ², Renu Chaudhary ¹, Sarvesh Kumar ³, Alimuddin Saifi ¹

Affiliations
1 Mahaveer College of Pharmacy, Meerut, Uttar Pradesh, IN
2 MIT Institute of Technology, Meerut, Uttar Pradesh, IN
3 H.N.B.G.U. (A Central University) Srinagar Garhwal, Uttarakhand, IN

Abstract

A solid lipid Microparticle reaches to the target site at controlled rate and show controlled release for better therapeutic result. This drug delivery system are prepare to obtained prolonged sustained or controlled drug delivery, to improves bioavailability, to enhance stability and to reduce toxic effects follows with target drug at specific site. The solid lipid micro particles of curcumin were prepared in a view to achieve high permeability of curcumin in brain through blood-brain-barrier. The solid lipid microspheres are prepared by hot melts microencapsulation technique was used to formulate solid lipid microspheres. Twelve formulations were prepared by varying concentration of surfactants (span 20, span 60, span 80 and Tween 80). The developed formulation were subjected to various parameter such as the particle size, % entrapment efficiency, production yield, % cumulative release, percentage yield and drug loading. Based upon highest entrapment efficiency, drug release and % cumulative release the F3 formulation was considered as the best formulation. The prepared microsphere were subjected to different evaluation parameter such as melting point, thin layer chromatography, solubility, FTIR, compatibility study and In-vitro drug release. The developed formulation shows spherical and smooth surface. The % drug release of F3 formulation was found to be 86.23% after 12 hr.

Keywords

Curcumin, Solid Lipid Microspheres, Span80

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