Informatics Publishing Limited

V. Harikrishnan ¹, M. Sreejith ², M. J. Elthose ¹, Akash Marathakam ³

Affiliations
1 Mookamabika College of Pharmaceutical Science and Research, Muvatupuzha, Kerala, IN
2 Nazareth College of Pharmacy, Thiruvalla, Kerala, IN
3 National College of Pharmacy Kozhikode, Kozhikode, Kerala, IN

Abstract

Gelucire is the group of vehicle got from blends of mono-, di-and tri-glycerides with PEG esters of unsaturated fats. They have a wide assortment of utilization in pharmaceutical definitions. These are utilized as a part of the arrangement of quick release and maintained release of drug in sustained manner. Keeping in mind the end goal to build the bioavailability of medications, the residence time of the orally controlled dose frame in the upper GIT should be drawn out. The principle ways to deal with drawing out the gastric residence time of pharmaceutical dosage form incorporates thickness control conveyance framework, which drift on gastric liquid and a resource for treat Diabetes sort II. Gastro retentive strong scattering could be accomplished of ineffectively solvent medication Glibenclamide with the assistance of polyethylene glycol and Gelucire 50/13. Then again managed discharge gastroretentive multiparticulates of metformin hydrochloride could be accomplished utilizing Gelucire 39/01 and 43/01 grades. Further both details can be investigated individual and also in mix for enhanced bioavailability by their pharmacokinetic and pharmacodynamic assessment in wistar rats.

Keywords

Gelucire, Metformin, Glibenclamide, Solid Dispersion.

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Akash Marathakam ¹, Vimal Mathew ¹, Zuhara Mariyam ¹, M. K. Unnikrishnan ¹

Affiliations
1 National College of Pharmacy, Kozhikode – 673602, Kerala, IN

Abstract

Examinations, chiefly for historic reasons, have been a crushing preoccupation for students, schools, universities, and the Indian society at large, particularly for many monolithic faculty-universities awarding coveted professional degrees in healthcare and engineering. The stress on bureaucratic expediency and confidentiality, fear of public disapproval, dearth of manpower, media sensationalism, litigations and the genuine threat of corruption, together compel universities to allocate bulk of their resources (human as well as capital) towards adopting a brutally centralized governance model for achieving an ostensibly "transparent" evaluation system. Although the university administration spends most of its time in planning, scheduling, organizing and conducting examinations, nearly 70% of student-evaluation, ironically, occurs in a single sitting lasting three hours and the answer paper is typically valued in about 8 minutes. Consequently, such evaluation systems ignore the functions and purpose of examinations, its content and construct validity, reliability, objectivity, its timing and timeliness, thereby perpetuating a ritualized, self-defeating, stagnating curriculum. While decentralisation of evaluation through autonomy is most desirable, training teachers to prepare question papers amenable to objective evaluation, with question papers validated for content/ difficulty levels, might help in the near term.

Keywords

Governance Models, Higher Education, Universities.

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M. K. Unnikrishnan ¹, Akash Marathakam ¹, Vimal Mathew ¹

Affiliations
1 National College of Pharmacy, Kozhikode 673 602, IN

Abstract

Oral rehydration therapy (ORT) is a simple and powerful remedy that saves millions of children from diarrhoeal deaths every year. Improvising a simple oral remedy for diarrhoea was a Third World priority because the West, with good sanitation and ready access to intravenous (IV) fluids, rarely encountered diarrhoeal deaths. The scientific evidence in support of ORT began with researchers demonstrating the ‘cotransport phenomenon’, in which glucose was shown to enhance sodium absorption by specific transporter proteins. The ensuing clinical trials with ORT solutions of varying concentrations of sugar and salt, produced inconsistent and sometimes dangerous results. Early success came with the crucial 1968 Chittagong trials, when cholera patients in shock were treated intra-gastrically with ORT solutions. Subsequent field trials confirmed that ORT saves lives, even without IV fluids. Yet, translating ORT to the community remained problematic, until the Bangladesh liberation war (1971–72) when Dilip Mahalanabis (Infectious Diseases Hospital, Kolkata) conducted the game-changing field trial in squalid refugee camps under extreme conditions. With neither doctors nor nursing support, family members administered ORT to dying patients. This pragmatic and frugal remedy went on to become the flagship public health programme under UNICEF and WHO. Though under-implemented to this day, ORT remains the greatest contribution from the Indian subcontinent towards achieving Sustainable Development Goals. ORT teaches many lessons: the delays in translating research to therapy, lure of gadgetry smothering frugal innovation, need for institutional endorsement from the West, in addition to the general indifference towards public health priorities.

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