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Sah, Abhishek K.
- Development and Evaluation of Mucoadhesive Sustained Release Tablet using Tamarindus indica Gum
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1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 4, No 2 (2014), Pagination: 77-82Abstract
In the present work, the mucoadhesive tablet of diclofenac (as a model drug) by using Tamarindus indica fruit gum as a binder was formulated. The preliminary evaluation of Tamarindus indica gum showed that bulk density 0.50 ± 0.4 g/cm3, tapped density 0.35 ± 0.8 g/cm3 and angle of repose 280 ± 0.26. The six tablet formulation were prepared by using 0.25%, 0.50%, 0.75%, 1%, 1.25% and 1.50% w/w of Tamarindus indica gum by direct compression (F1, F2, F3, F4 and F5 respectively). Tablets were subjected for evaluation of uniformity of weight, hardness, friability, drug content uniformity, swelling behaviour, release rate study, mucoadhesive study, and tensile strength study. Formulation was studied for drug additive interaction (FTIR). F4 is found to be optimized formulation. The in-vitro drug release of F4 formulation exhibits complete release of Diclofenac Sodium with nonfiction first order release kinetic. The formulation F4 exhibited tensile strength 0.27 N with 10 hrs of mucoadhesion. From the study it can be conclude that the Tamarindus indica gum used as mucoadhesive sustained release tablet.References
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- Role of Antioxidants in Developing Novel Delivery Systems as Longevity Therapy
Abstract Views :188 |
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Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN
Source
Research Journal of Science and Technology, Vol 6, No 3 (2014), Pagination: 119-127Abstract
An antioxidant is a molecule capable of inhibiting the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons from a substance to an oxidizing agent. Oxidation reactions can produce free radicals. Antioxidants terminate these chain reactions by removing free radical intermediates, and in the body will drastically determine how long one will live. We have reviewed here sources of antioxidant, the network of antioxidant, supplements, causes of ageing, antiageing nutrition and different lipids based delivery system in longevity therapy. In addition to these uses of natural antioxidants in medicine, the compounds have many industrial uses, such as preservatives in food and cosmetics and preventing the degradation of rubber and gasoline. It is concluded that Novel lipid based delivery systems reviewed here possess the potential to develop as the new generation smarter carrier systems for topical delivery of antioxidants.Keywords
Antioxidant, Supplements, Longevity.- Formulation and Evaluation of Sustained Release Topical Gel of Flurbiprofen Using Natural Polymers
Abstract Views :220 |
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Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 5, No 1 (2014), Pagination: 7-11Abstract
In this study, to formulate Sustained Release Topical Gel of Flurbiprofen were all the prepared topical gel formulations contain different drug: polymer ratio using tamarind gum for long term therapy of rheumatoid arthritis. Flurbiprofen is a second generation non-steroidal anti-inflammatory agent, which is widely used in alleviating pain and inflammation. But its short half-life (only 3-4 hr), so its causes more fluctuation. After oral administration Flurbiprofen causes to produces heart burn, nausea, loose motions, pruritus, etc. The present study based on the preparation of bioadhesive topical gel of Flurbiprofen, so as to avoid all gastric side effects. For the preparation of bioadhesive topical gel natural polymer Tamarindus indica(plant Tamarind) was used. Bioadhesive polymers are the agents which increases the contact between the formulation and biological membrane, so as to avoid the fluctuation of formulation and behave as a sustained release formulation. In the present study, prepared bioadhesive topical gel was evaluated with the help of different parameters like drug content, spreadability, extrudability, swelling index study, in-vitro drug diffusion study. On the basis of in-vitro drug diffusion study measurement property of gel, we have concluded that natural polymer Tamarindus indica the best polymer for the preparation of sustained release bioadhesive topical gel.Keywords
Topical Gel, Bioadhesion, Natural Polymer, Sustained Release.- Tablet Coating Technology:An Overview
Abstract Views :149 |
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Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010 (C.G.), IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010 (C.G.), IN
Source
Asian Journal of Pharmacy and Technology, Vol 4, No 2 (2014), Pagination: 83-97Abstract
Tablet coatings must be stable and strong enough to survive the handling of the tablet. Modern tablet coatings are polymer and polysaccharide based with plasticizers and pigments included. Coatings are necessary for tablets that have an unpleasant taste, and a smoother finish makes large tablets easier to swallow, extend the shelf-life of components, controlled release, bioadhesive and sustained drug release. We were reviewed here pharmaceutical coating process, type of coatings, stability testing, quality control and advanced coating technology. This review concluded on Coating enhances the quality of products and controls the bioavailability of the drug which provides physical protection to facilitate handling. This includes minimizing dust generation in subsequent unit operations.Keywords
Tablet Coating.- Floating: A Site Specific Drug Delivery System
Abstract Views :255 |
PDF Views:0
Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 3 (2014), Pagination: 149-155Abstract
Gastro retentive drug delivery systems are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. We have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastro retentive approaches designed and developed until now, i.e. high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems. Finally, advantages of gastro retentive drug delivery systems were covered in detail. The purpose of this paper is to review the recent literature and current technology such as Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamic ally balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. Used in the development of gastro retentive dosage forms.Keywords
Site-Specific Drug Delivery System, Gastric Retention, Current Technology, Gastro Retentive Dosage Forms.- Floating:A Site Specific Drug Delivery System
Abstract Views :215 |
PDF Views:0
Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 6, No 4 (2014), Pagination: 149-155Abstract
Gastro retentive drug delivery systems are the systems which are retained in the stomach for a longer period of time and thereby improve the bioavailability of drugs. We have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastro retentive approaches designed and developed until now, i.e. high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems. Finally, advantages of gastro retentive drug delivery systems were covered in detail. The purpose of this paper is to review the recent literature and current technology such as Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), also known as hydrodynamic ally balanced systems (HBS), swelling and expanding systems, polymeric bioadhesive systems, modified-shape systems, high-density systems, and other delayed gastric emptying devices. Used in the development of gastro retentive dosage forms.Keywords
Site-Specific Drug Delivery System, Gastric Retention, Current Technology, Gastro Retentive Dosage Forms.- Gastro-Retentive Mucoadhesive Nanoparticle for Sustained Drug Delivery System
Abstract Views :189 |
PDF Views:1
Authors
Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur 492001 (C.G.), IN
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur 492001 (C.G.), IN