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Dharamsi, Abhay
- Development and Evaluation of a Polyherbal Tablet for Polycystic Ovarian Syndrome (PCOS)
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Authors
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1 Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391110, Gujarat, IN
2 Parul Institute of Pharmacy, Parul University, Vadodara - 391110, Gujarat, IN
1 Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391110, Gujarat, IN
2 Parul Institute of Pharmacy, Parul University, Vadodara - 391110, Gujarat, IN
Source
Journal of Natural Remedies, Vol 22, No 2 (2022), Pagination: 160 - 174Abstract
The main objective of the present study was to develop and evaluate polyherbal tablet for the treatment of Polycystic Ovarian Syndrome (PCOS). For the formulation of tablet, the herbs were selected based on the concepts of pathophysiology and Ayurvedic perspective of the disease. The extracts of T. foenum graceum, C. longa, B. aristata, S. asoka, B. variegata and Guggul purified in cow’s urine was used for the preparation of polyherbal tablet. The physicochemical, phytochemical evaluation and quantification of markers by HPTLC of crude drugs and extracts were performed. The guggul was used as binder in different proportion for the preparation of tablet. Pre-formulation study of the powder blend and post compression evaluation of tablet was done by various parameters like weight variation, friability, hardness, thickness, diameter, disintegration time, in-vitro dissolution and accelerated stability study. The physicochemical evaluations of crude drugs yielded results which were in accordance with the monograph’s standard values. The phytochemical analysis of the extracts revealed the presence of variety of phytoconstituents. From the results of HPTLC quantification the amount of curcumin (7.14%) in C. longa, diosgenin (40.6%) in T. foenum graceum ,T. foenum graceum, berberine hydrochloride (4.83%) in B. aristata, catechin (3.48%) in S. asoka, lupeol (0.11%) in B. variegata and Z-guggulsterone (0.140%) and E-guggulsterone (0.146%) in purified guggul was found. The micrometrics of the powder blend of all the formulations showed good flow properties. Formulation F3 showed better results compared to other formulations in post compression evaluation. Accelerated stability study showed that the formulation F3 was stable during the course of study.Keywords
Micromeritics, Polyherbal Formulation, Polycystic Ovarian Syndrome, Physicochemical EvaluationReferences
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- The Electro-Spun Sublingual Film Containing Curcumin Micelles
Abstract Views :101 |
PDF Views:77
Authors
Affiliations
1 Department of Pharmaceutics and Pharmaceutical Technology, Parul Institute of Pharmacy, Parul University, Vadodara - 391760, Gujarat, IN
1 Department of Pharmaceutics and Pharmaceutical Technology, Parul Institute of Pharmacy, Parul University, Vadodara - 391760, Gujarat, IN
Source
Journal of Natural Remedies, Vol 23, No 1 (2023), Pagination: 205-211Abstract
Hydrophilic polymers D-tocopheryl polyethylene glycol succinate (TPGS-1000) and Poloxamer-188 were combined for the formulation of a sublingual film that aids in improving the oral bioavailability of the drug curcumin, which is not very soluble. For the formulation of micelles, the thin-film hydration technique was used and then electro-spun into a sublingual film that contained 13 % w/v PVP. Following that, prepared micelles and films were assessed and evaluated (particle size, PDI, zeta potential, %EE, pH studies, disintegration time, and in vitro drug release). According to the findings, the average particle size of the blended micelles was 230.2 nm. The ideal formulation of mixed micelles had a mean zeta potential and PDI of 20.73 mV and 0.258±0.038, respectively. Additionally, an entrapment efficiency of 82% was reached. In an aqueous medium, the film disintegrated in 40±10 seconds. Micelles were incorporated into the film without losing their integrity. Importantly, as compared to a pure drug, the films with micelles put on them showed improved bioavailability, high permeability and rapid absorption of the curcumin. Compared to the pure drug, the bioavailability of the films was increased by around 2.18 times due to the presence of mixed micelles loaded with curcumin. The results also showed that micelles-loaded sublingual films performed well in vitro for bioavailability improvement. In the end, it was found that films containing a mixture of poloxamer-188 and TPGS-1000 micelles would function effectively as carriers to boost curcumin’s bioavailability.Keywords
Electro Spinning, Micelles, Poloxamer-188, Sublingual Film, TPGS.References
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