Informatics Publishing Limited

Abdul Saleem Mohammad ¹, Swetha Devidi ², Nikhat Fatima ¹, Humera Badar ¹, Syeda Saba Sulthana ¹, Mohammad Akthar Sulthana ³, Nuha Rasheed ⁴

Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutical Chemistry, St. Mary’s Pharmacy college, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Vivekananda Group of Institutions (Pharmacy Department), Near Ramoji Film City, Ranga Reddy District, Hyderabad, Telangana, 501511, IN
4 Department of Pharmaceutics, Nizam Institute of Pharmacy, Near Ramoji Film City, Pochampally (Mandal), Deshmukhi Village - 508284, Nalgonda Dist., Telangana, IN

Abstract

Quality is the primordial intention to any pharmaceutical industry and its products manufactured. The current interest in the pharmaceutical industry is to obtain best quality. Acquainted with a practice that puts us in common and routine convention ensured to deliver a quality that sounds globally in terms of a spoken quality is on the dais of pharmaceutical arena. Validation is the mean of catering enormous benefits to even more than the acceptable quality level which in the global standard scale. Validation is the art of designing and practicing the designed steps alongside with the documentation. Validation and quality assurance will go hand in hand, ensuring the through quality for the products. Process Validation emphasize on process design elements and maintaining process control during commercialization and communicate that process validation is an ongoing program and align process validation activities with product life cycle. Process validation also emphasizes the role of objective measures and statistical tools and analyses and emphasizes knowledge, detection, and control of variability and gives assurance on consistent of quality/productivity throughout life cycle of product additionally a view of validation against the quality assurance, drug development and manufacturing process has been discussed.

Keywords

Quality, Validation, Types of Validation, Process Validation, Protocol, Regulatory Basis, Master Plan.

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Duggi Adilakshmi ¹, Abdul Saleem Mohammad ², Nuha Rasheed ³, Kathula Umadevi ², Chandana Pasupuleti ¹

Affiliations
1 Department of Pharmaceutics, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN

Abstract

The present investigation an attempt has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient compliance, by developing sustained release matrix tablets of Allopurinol. Sustained release matrix tablets of Allopurinol, were developed by using different drug: polymer ratio. Kollidon SR, Hydroxypropyl methylcellulose K15M, K100M as matrix former. All lubricated formulations were compressed by direct compression and by wet granulation method. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, thickness, in vitro dissolution, and swelling index. All the formulation showed compliance with pharmacopoeial standards. Among the different formulation, B8 showed sustained release of drug for 12 hours with 86.55% release. The regression coefficient value of Higuchi plot was found to be 0.9925 that showed that drug was released by diffusion mechanism. The slope value of korsmeyer ‐peppas equation was found to be 0.5062 which indicating that drug was released by non‐fickian release mechanism. The R2 value for Hixson Crowell plot was found to be 0.9919 which indicates that drug release was limited by drug particle dissolution rate and erosion of the polymer matrix. Thus, drug in combination with Hydroxy propyl methyl cellulose K100M were found to be effective in retarding the release of Allopurinol.

Keywords

DSC Studies, FTIR Studies, HPMC, Polymers, Sustained Release.

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Chandana Pasupuleti ¹, Abdul Saleem Mohammad ², Nuha Rasheed ³, Kathula Umadevi ², Duggi Adilakshmi ¹

Affiliations
1 Department of Pharmaceutics, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN

Abstract

The aim for the present study was to develop a delivery system wherein the retention of ofloxacin could be achieved for increasing local action in gastric region against Helicobacter pylori. Therefore the present investigation is concerned with the development of rice bran oil entrapped zinc pectinate beads containing ofloxacin, which after oral administration were designed to prolong the gastric residence time, thus to increase the bioavailability of the drug. A suitable method of analysis of drug by UV spectrophotometry was developed. Ofloxacin showed maximum absorption at a wavelength 294.5 nm in pH 1.2 hydrochloric acid buffer. The value of regression coefficient (r²) was found to be 0.999, which showed linear relationship between concentration and absorbance. Preformulation study for drug and polymer compatibility by DSC and FTIR gave confirmation about the purity of the drug and showed no interaction between drug and the polymers.

Keywords

Ofloxacin, Buffer, DSC, FTIR, Bioavailability, Microbeads.

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Nuha Rasheed ¹, Abdul Saleem Mohammad ², Seema Farheen ³, Shaik Zubair ³

Affiliations
1 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Department of Pharmaceutics, Vijaya College of Pharmacy, Munaganur (V), Hayath Nagar (M), Hyderabad, Telangana, IN

Abstract

Bosentan is an endothelial receptor antagonist (ERA) indicated for the treatment of Pulmonary arterial hypertension (PAH). The aim of the present study involves the development of controlled release tablets of bosentan. The tablets were prepared to release the drug for a prolong period of time within the GIT, to enhance the bioavailability, to minimize the dosing frequency, and to improve the patient compliance. The tablets were formulated by using various polymers like hydroxyl propyl methyl cellulose, acacia and xanthum. The formulated tablets were evaluated. The drug release from the optimized formulation (F7) was found to be the best after observing the results of dissolution rate and pre & post formulation studies.

Keywords

Controlled Release, Hydroxyl Propyl Methyl Cellulose (HPMC), Bioavailability, Endothelial Receptor Antagonist (ERA), Pulmonary Arterial Hypertension (PAH), Gastro-Intestinal Tract (GIT).

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Abdul Saleem Mohammad ¹, Nikhat Fatima ¹, Humera Badar ¹, Syeda Saba Sulthana ¹, Chandan Mohanty ², Mohammad Akthar Sulthana ³

Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, St. Mary’s Pharmacy College, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Vivekananda Group of Institutions(Pharmacy Department), Near Ramoji Film City, Ranga Reddy District, Hyderabad, Telangana, 501511, IN

Abstract

A review on Al-Hijamah (Cupping therapy) includes the detailed introduction, areas or points of hijamah that are cupped on the various parts of the human body with it's mutual benefits, types of it whether it is dry or massage or wet therapy. These types of therapies are varient from one another while bleeding of blood via wet cupping is possibly beneficial that it can heal many ailments of our body. The safety of this type of therapy is much appreciable which doesn't hurt or leave marks of the punctures on the body while cupping is performed. Much more new therapies were discussed under it related to organs and possible disease that can be cured by cupping. Lot of variance has been distinguished between blood donation and hijamah regarding their mutual remedies and advantages.

Keywords

Al-Hijamah, Cupping, Venesection, Cauterization.

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Abdul Saleem Mohammad ¹, Nuha Rasheed ², Mohammed Nayeem Uddin ³, Hajera Hafeez ⁴

Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
3 Department of Pharmacology, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda (Dist)-508284, Telangana, IN
4 Department of Pharmaceutics, Global College of Pharmacy, Beside to Moinabad Police Station, Moinabad, Ranga Reddy (Dist)-501504, Telangana, IN

Abstract

The aim of present study confirmed that the SEDDS formulation can be used as a possible alternate to traditional or classical formulations of Ibuprofen to improve its bioavailability using varied quantities of goat fat as an excipient and tween 60 as a surfactant which is a drug in the nonsteroidal anti-inflammatory drug (NSAID) class used for treating pain, fever and inflammation which is also known to be isobutylphenylpropanoic acid. The investigation proved that the formulated dosage forms showed good release profile as well as acceptable tablet properties. The batches with higher tween60: goat fat content ratios gave better release rates. The SEDDS of Ibuprofen was successfully prepared and the tablets prepared passed the various evaluation tests conducted. This method has advantage of reliance on cheap raw materials such as goat fat with fewer processing steps, best suited for lipophilic drugs where the resulting emulsification gives faster dissolution rates and absorption. Invivo evaluation of this novel dosage form is currently in progress. Self-emulsifying drug delivery systems are a promising approach for the formulation of lipophilic drug compounds having poor aqueous solubility. The oral delivery of hydrophobic drugs can be made possible by SEDDSs which have been shown to improve oral bioavailability substantially. From the formulation point of view it is necessary to consider the emulsification properties of lipid base vehicle and the solubility of drug in the lipid surfactant mixture to form a completely miscible solution so as to solubilize adequate quantities of drug in lipid vehicle. Lipids have an important role in absorption process. Thus, SEDDS plays an important role in the formulation of poorly water soluble drugs and enhancing their bioavailability.

Keywords

SEEDS, Surfactants, Tween-60, Goat Fat, Beer's Law, Lipophilic.

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Habeeb Ahmed ¹, Mohammed Ehtesham ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

The present subject is on the review of various limit test and titrations which are commonly conducted in the Chemistry lab. Limit tests are a category of impurity tests in which a solution of an unknown sample is compared to a standard that contains the impurity at the product limit. Generally this definition applies to limit tests that are in widespread use in various pharmacopoeial compendia, such as United States Pharmacopoeia (USP), European Pharmacopoeia (EP), Japanese Pharmacopoeia (JP) and Food Chemicals Codex (FCC). These tests are used to make a simple pass/fail evaluation of the sample. Typically this category of test relies on the comparison of an unknown sample to a standard solution. Often these tests rely on a visual evaluation by the technician, though some may rely on instrumental analysis of the sample.

Keywords

Limit Tests, Arsenic, End Point, Titration, Equivalent Point, and Indicator.

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Sufia Raiz ¹, Syeda Hafsa Noor ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

What do you need to know as medical laboratory scientists when performing electrolyte replenisher? What new information should you consider regarding best laboratory practice in electrolyte replenisher? This review article will answer some of these questions.

Keywords

Electrolytes, Body Fluids, Lysis, Cations, Anions, Metabolism.

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Juveriya Fatima ¹, Saniya Khan ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

The present article is describes a brief overview of various types of acidifiers, antacids and cathartics. For organic acids to be increasingly used in livestock feedstuffs, there is a need for an improved form: one that is less corrosive, safe, effective and easy to use. These are used for the purpose of good health.

Keywords

Acidifying Agents (dil. HCl), Acid Indigestion, Chronic, Heartburn, Inflamed Bowel, Inflammation, Cathartics Colon, Hyperosmotics, Stool, Steatorrhea.

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Rana Khan ¹, Aizaz Ahmed Khan ², Nuha Rasheed ³, Abdul Saleem Mohammad ⁴

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Engineering and Technology, Nizam Institute of Engineering and Technology, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
4 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

The development of radiotraces with defined affinities for specific receptor systems is a potentially useful approach to the design of radio pharmaceuticals for nuclear medicine. Radio labeled ligands, such as hormones and neurotransmitters, are being synthesized and evaluated as diagnostic tools for diseases which can be characterized either by changes in receptor concentration or by novel receptor expression. Since the utility of a radio pharmaceutical is dependent upon the achievement of adequate ratios of target to non-target accumulation of radio activity, design of radio traces via the receptor approach attempts to exploit those systems in which receptor is present in significantly higher concentration at potential target sites such as tumors. Receptormediated radio tracers are also currently being used in animal models to investigate the normal tissue distribution of drug and hormone receptors and the in-vivo pharmacokinetics of receptor binding. The successful development of receptor-avid radiopharmaceuticals will depend upon the ability to synthesize ligands of high specific radio activity which retain the high affinity and binding specifically for the receptor after radio labeling.

Keywords

Radiopharmaceutical, Nuclear Medicine, Alpha Rays, Beta Rays, Gamma Rays, Radio Isotopes, Osteosarcoma, Therasphere, Yttrium 90, Hydroxyapatite.

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Farheen Fatima Ahsan ¹, Afreen Fatima ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

The present review is on various medicinal gases that are very commonly used in anaesthesia and intensive cares that include nitric oxide, heliox, carbon dioxide, entonox, medical air, nitrous oxide, oxygen.etc. The conceptual importance of medicinal gases for its pharmaceutical importance has been discussed in detailed account.

Keywords

Drugs, Device, In Vitro, In Vivo, Inflammable, Gases, Pharmaceutical Gases.

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Yousra ¹, Sukaina Fatima ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

What do you need to know as medical laboratory scientists when performing fundamental of analytical chemistry? What new information should you consider regarding best laboratory practice in fundamental of analytical chemistry? This review article will answer some of these questions.

Keywords

Analysis, Gravimetry, Spectroscopy, Quantitative, Qualitative, Analytical Chemistry.

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Ameena Samreen ¹, Mohammed Riyaz ¹, Amtul Asiya ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharmacy, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

The present objective of the article describes a brief overview of various subjects of B. Pharmacy course syllabus designed by Jawaharlal Nehru Technological University Hyderabad (JNTUH) (for Regulations R09, R13, R15, and R16) for its significance. Pharmacy is the science and technique of preparing and dispensing drugs. This is a health profession that links health science with chemical sciences and it aims to ensure the safe and effective use of pharmaceutical drugs. Pharmaceutical care holds that the important role of the pharmacist is the responsible provision of drugs therapy for the purpose of achieving definite outcomes that improve a patient quality of life. Pharmacist are experts on medication .In this article various subjects of Pharmacy are Insisted.

Keywords

Incompatibilities, Polymerization, Pharmacokinetics, Centrifugation, Crystallization, Thermodynamics, Biosynthesis, Purification, Pharmaceutical Technology, Medicinal Chemistry, Herbicides.

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Ayesha Begum ¹, Syeda Sharifa Nida ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharmacy, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

In order to systematically analyze the effects of nucleosides modification of sugar in DNA polymerase reaction, we synthesized 16 modified templates containing 2', 4'-Bridged nucleoside-5'-triphosphates with different bridged structures. Among five types of thermos table DNA polymerases used, Taq, Phusion HF, vent (exo-), KOD Dash and KOD (exo-). The KOD Dash and KOD (exo-) DNA with polymerizes could smoothly read through modified templates containing 2'-0,4'-C-methylene linked nucleotides at standard enzyme concentration for five minutes. The modified templates containing sequence of seven successive 2',4'-bridged nucleotides could not be completely transcribed by any of the DNA polymerase used, yields of longer elongated products decreased in order to steric bulkiness of the modified sugar. Successive incorporation of 2',4'-bridged nucleotides into extending strands using 2',4'-bridged nucleotide -5'-triphosphate was much more difficult.

Keywords

Nucleosides, Coding, Polymerization, Systematic Analysis.

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Hafsa ¹, Asfa ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

Pharmaceutical aids are the drugs and substances which have no or little pharmacological effect but they are essentially used in the preparation of pharmaceutical dosage form (like tablet, injection, emulsion, ointments etc). In this article we will be studying about the substances needed in the preparation, preservation and storage of pharmaceutical products and how are they classified into different categories and why are they necessary in preparation and does that help to the pharmacist?

Keywords

Excipient, Vehicles, Pharmacopoeia, Antiadherents, Binders, Diluents, Ingredient, Indian Pharmacopoeia, United States Pharmacopoeia, Buffering Agents, Ointments, Dosage Etc.

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Safa Mohammed Sadiq ¹, Amtul Kareem ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma.D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri (Dist)-508284, Telangana, IN

Abstract

The treatment of microbial infection is increasingly complicated by the ability of microbe to develop resistance to antimicrobial agents. Antimicrobial agents are often categorized according to their principle mechanism of action. Mechanism includes interference with cell wall synthesis, inhibition of protein synthesis, interference with nucleic acid synthesis and disruption of bacterial membrane structure.

Keywords

Antimicrobials, Antiseptics, Disinfectants, Germicides, Bacteriostatics, Sanitizers, Oxidation, Halogenation, Protein Precipitation, Zinc Peroxide, Sodium Hypochlorite, Mild Silver Protein.

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Abdul Saleem Mohammad ¹, Nuha Rasheed ², Hajera Hafeez ³, Mohammed Nayeem Uddin ⁴

Affiliations
1 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V)-508284, Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist), Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V)-508284, Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist), Telangana, IN
3 Department of Pharmaceutics, Global College of Pharmacy, Beside to Moinabad Police Station, Moinabad-501504, Rangareddi (Dist), Telangana, IN
4 Department of Pharmacology, Nizam Institute of Pharmacy, Deshmukhi (V)-508284, Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist), Telangana, IN

Abstract

Generally, a product manager manages one or more tangible products. However, the term may be used to describe a person who manages intangible products, such as music, information, and services. A product manager's role in tangible goods industries is similar to a program director's role in service industries. Diverse interpretations regarding the role of the product manager are the norm. The product manager title is often used in many ways to describe drastically different duties and responsibilities. Even within the high-tech industry where product management is better defined, the product manager's job description varies widely among companies. This is due to tradition and intuitive interpretations by different individuals. A product manager communicates product vision from the highest levels of executive leadership to development and implementation teams. The product manager is often called the product "CEO". The product manager investigates, selects, and drives the development of products for an organization, performing the activities of product management. A product manager considers numerous factors such as intended demographic, the products offered by the competition, and how well the product fits with the company's business model. The product manager is often considered the CEO of the product and is responsible for the strategy, roadmap, and feature definition for that product or product line. The position may also include marketing, forecasting, and profit and loss (P&L) responsibilities.

Keywords

CEO, Manager, Product, Executive, Responsibilities, Industry.

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Nuha Rasheed ¹, Abdul Saleem Mohammad ², Hajera Hafeez ³, Seema Farheen ¹

Affiliations
1 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutics, Global College of Pharmacy, Beside to Moinabad Police Station, Moinabad, Rangareddi (Dist)-501504, Telangana, IN

Abstract

The objective of the study was to prepare and evaluate ACS contain pellets by the process of extrusion followed by spheronization for controlled release. The method employed was economical and does not imply the use of toxic solvents. The aqueous SLS which forms micropores on the surface of the pellets. The results of micromeritic properties, Hausner ratio and friability of the pellets were well within the limits which indicate good flow potential for the prepared pellets. Drug contains pellets exhibited spherical nature as evidenced by SEM photomicrographs and sphericity studies. From the FTIR and DSC studies, it was observed that there was no chemical interaction between the drug and polymers used indicates that drug was in stable form. The drug content study revealed uniform distribution of the drug in the pellets. The drug release rate was found vary among the formulations depending on the compositions of polymers used. The obtained dissolution data indicated that the drug release through the microporous polymeric membrane follows Fickian diffusion. Optimized formulation F5 and marketed product Aceton SR100 mg tablet showed similarity in drug release profile. Formulation F5 is an ideal formulation for once daily administration. From the present study, it can be concluded that the prepared matrix pellets demonstrate the potential use of SA/GPS/MCC blend for the development of controlled drug delivery systems for many water insoluble drug.

Keywords

Aceclofenac, NSAID, Surfactants, Formulation, Lipophilic, Hydrophilic, Gastrointestinal Fluid (GIF).

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Raafia Aseena ¹, Syeda Zeba Hyder Zaidi ¹, Nuha Rasheed ², Abdul Saleem Mohammad ³

Affiliations
1 Department of Pharma. D, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist)-508284, Telangana, IN
2 Department of Pharmaceutics, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist)-508284, Telangana, IN
3 Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist)-508284, Telangana,, IN

Abstract

The study was carried out to ascertain anti asthmatic, analgesic and anti convulsant activities of the medicinal plant Bryonia laciniosa. Anticonvulsant activity was evaluated by Maximum electroshock induced seizure test. The anti asthmatic activity was estimated by mesenteric mast cell count by Atopic allergy method. Analgesic activity was estimated by Eddy's hot plate and Analgesiometer tests. The results indicated that 70% alcoholic extract of Bryonia laciniosa increased the antiasthmatic activity, analgestic activity and also anticonvulsant activity.

Keywords

Bryonia laciniosa, Atopic Allergy Method, Eddy’s Hot Plate Analgesio Meter, Electric Shock Method.

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