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Muralidharan, A.
- Neuropharmacological Activity of Trigonella foenum graecum Linn. Seeds
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Journal of Natural Remedies, Vol 7, No 1 (2007), Pagination: 160-165Abstract
Objective: To evaluate the neuropharmacological activity of Trigonella foenum graecum (Fenugreek) seeds. Methods: Total alcoholic extract (TA), Total aqueous extract (TQ), Petroleum ether extract (PE), Total alkaloidal extract (TK), Total glycosidal extract (TG), Fenugreek oil (FO), Diosgenin (DI) and Trigonelline (TR) were assessed for their neuropharmacological activity in primary screening studies, locomotor activity and phenobarbitone induced sleeping time using albino Wistar rats. The extracts TA, TQ, PE and FO were administered 100 mg/kg b.w. and TK, TG, DI and TR were administered 50 mg/kg b.w. intraperitoneally. Caffeine (CF) (48 mg/kg) and Chlorpromazine hydrochloride (CP) (150 μg/kg) were used as standard drugs. Results: In all the studies, all the extracts and active principles except TQ showed significant central nervous system (CNS) stimulant activity, while TQ alone showed significant CNS depressant activity. Conclusion: Thus from the above studies, the active compounds present in the fenugreek seed extracts possess CNS stimulant and depressant activities.Keywords
Trigonella foenum graecum, Locomotor Activity, Phenobarbitone Induced Sleeping Time- Bioelectricity Generation by Proton Exchange Membrane-Based Microbial Fuel Cell from Sewage Substrate
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Authors
Affiliations
1 Department of Genetic Engineering, School of Bioengineering, SRM University, Chennai 603 203, IN
2 Department of Zoology, Presidency College, Chennai 600 005, IN
1 Department of Genetic Engineering, School of Bioengineering, SRM University, Chennai 603 203, IN
2 Department of Zoology, Presidency College, Chennai 600 005, IN