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H. Berrougui , E. Marhuenda , W. Haddad , M. Hmamouchi , A. Khalil , A. El-Bouadili , M. D. Herrera

Abstract

The effect of seed methanolic, ethyl-acetate and chloroformic extracts of Peganum harmala L. on KCl- and Noradrenaline- induced contractions of aortic strips was studied. In aortic strips with endothelium intact, contractions induced using 80 mM KCl and 10^-6 M Nor-adrenaline were dose-dependently relaxed by the extracts, a more significant effect being seen with Nor-adrenaline-induced contractions. Following mechanical damage to the aortic endothelium, the results showed that the inhibition of contraction by the three extracts was not endothelium dependent. The rank order of relaxation potency was MeOH > EtoAc> CHCl₃-extracts of Peganum harmala L. The results suggest that the relaxation effect of the three alkaloids-rich extracts may be attributed to the inhibiting of the AMP cyclic nucleotide PDE (Phosphodiesterase).

Keywords

Peganum harmala L., Extracts, Aortic, Vasorelaxation. Corresponding Author

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A. A. Basheer , A. I. Taha , Kh. Q. Mansour , A. Khalil , T. Rabeh

Abstract

One of the most famous problem faces the coastal agricultural area is the saline-water intrusion from sea. This study endeavors at detailing the prevailing subsurface conditions from the viewpoint of groundwater location, depth and quality. Two well-known geophysical methods have been used and applied to determine the depth of the fresh water aquifer and the saline water intrusion. The vertical electrical sounding and time-domain electromagnetic sounding have been pertained in the same 67 sites, which covers the study area. Analysis and interpretation of the obtained results reveals that, the subsurface consists of three geo-electrical layers with a gentle general slope towards the sea. The fresh water overlies saline water. It deserves mention to note that the fresh water depth varies between 0.5 and 65 m. under the ground surface. The saline water depth varies between 23 and 83 m. below the ground surface.

Keywords

ER; TEM; Saline water intrusion; Fresh water aquifer; Qantar Shark Area; Sinai Peninsula, Egypt

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