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A. Joshi ¹

Affiliations
1 Dept. of Endocrinology, Topiwala National Medical College and BYL Nair Ch Hospital, Mumbai, IN

Abstract

No Abstract

Keywords

No Keywords given

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A. Joshi ¹, R. Vaidya ²

Affiliations
1 Topiwala National Medical College and BYL Nair Ch. Hospital Mumbai, IN
2 Endocrine Metabolic Unit, MRC-KHS & Consultant, Vasudha Clinic, Mumbai, IN

Abstract

No abstract.

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V. Deshmukh ¹, A. Joshi ²

Affiliations
1 Dinanath Mangeshkar Hospital, Pune, IN
2 Topiwala National Medical College and BYL Nair Hospital, Mumbai, IN

Abstract

No Abstract.

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B. R. Sharma ¹, A. Joshi ¹, P. K. Varthakavi ¹, M. Chaddha ¹, N. Bhagwat ¹, T. B. Lathia ¹, S. Mittal ¹, P. Pawal ¹, P. Dalwadi ¹

Affiliations
1 BYL Nair Charitable Hospital and Topiwala National Medical College, Mumbai, IN

Abstract

No Abstract.

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A. Joshi ¹, P. Varthakavi ²

Affiliations
1 Bhaktivedanta Hospital, Mandapeshwar Clinic, Mumbai, IN
2 Department of Endocrinology, T.N. Medical College and BYL Nair Hospital, Mumbai, IN

Abstract

No Abstract.

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A. Joshi ¹, S. Jain ¹

Affiliations
1 Department of Foods and Nutrition, College of Home Science, Maharana Pratap University of Agriculture and Technology, Udaipur-313001, IN

Abstract

Enteral tube feeding is the standard nutritional support modality for patients with a functioning gastrointestinal tract. Gastrointestinal tract (GIT) is the largest immune organ in the body containing 65 per cent of the body's overall immune tissue and upto 80 per cent of its immunoglobulin producing cells. Enteral nutrition is the preferred method of nutritional support as gut associated lymphoid tissue (GALT) attributes upto 60 per cent of total body immunity and enteral nutrition promotes mucosal viability and immunologic function.

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R. Punasiya ¹, A. Joshi ², S. Gupta ², J. Punasiya ²

Affiliations
1 G.R.Y. Institute of Pharmacy, Borawan, Khargone (M.P.), IN
2 GRY Institute of Pharmacy, Borawan, Khargone (M.P.) 451228, IN

Abstract

There is considerable interest in the skin as a site of drug application both for local and systemic effect. However, the skin, in particular the stratum corneum, poses a formidable barrier to drug penetration thereby limiting topical and transdermal bioavailability. Skin penetration enhancement techniques have been developed to improve bioavailability and increase the range of drugs for which topical and transdermal delivery is a viable option. This review describes enhancement techniques based on drug/vehicle optimization such as drug selection, prodrugs and ion-pairs, supersaturated drug solutions, eutectic systems, complexation, liposome, vesicles and particles. Enhancement via modification of the stratum corneum by hydration, chemical enhancers acting on the structure of the stratum corneum lipids and keratin, partitioning and solubility effects are also discussed. The mechanism of action of penetration enhancer's, retarders and their potential for clinical application is described.

Keywords

Transdermal Delivery, Skin Penetration, Enhancer, Retarder.

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R. Punasiya ¹, A. Joshi ², S. Yadav ², K. Patidar ², K. Kapse ²

Affiliations
1 G.R.Y. Institute of Pharmacy, Borawan, Khargone (M.P.), IN
2 GRY Institute of Pharmacy, Borawan, Khargone (M.P.) 451228, IN

Abstract

Human and veterinary medicines have not been so well succeeded in order to achieve their goals concerned with the treatment of various types of infections. The antibiotic activity of Punica granatum Linn. (Fresh leaves) extract was evaluated by the agar diffusion method and agar disc diffusion to determine the zone of inhibition. The extract of P. granatum presented potential antibiotic action over all the assayed strains, forming 10 to 36 mm diameter inhibition zones. This paper's results claim the effectiveness of the extract of P. granatum as a potential antibacterial agent and display the significance of evaluating new substances with antimicrobial potential, which can contribute to alternative therapeutics for medicine.

Keywords

Punica granatum, Aqueous Extract, Methanol Extract and Antibiotic Activity.

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Ajay Sharma ¹, A. Joshi ¹, G. Rajamani ¹, P. N. Mathur ¹

Affiliations
1 Department of Molecular Biology and Biotechnology, MPUAT, Rajasthan College of Agriculture, Udaipur-313001 (Rajasthan), IN

Abstract

Two month old stem explants of Carica papaya L. cv. Coorg Honeydew showed 80 per cent callus initiation on Murashige-Skoog (MS) nutrient medium supplemented with 3.0 μM of 2,4-dichloro phenoxyacetic acid (2,4-D). Treatment with phytohormones like Kinetin (Kin) or Benzyl adenine (BA) (@ 0.2 to 2.0 mg l^-1) were found to have no role with regard to callus initiation. However, these initiating calli when subcultured on MS + 2,4-D (3.0 μM) + Kin (0.5 mg l^-1) showed a two-fold growth by proliferation within 21 days after the date of sub-culture. During this period, 30 per cent of the callus tissue underwent necrosis. Thereafter, the best of 70 per cent friable, healthy calli were recultured on MS + 2,4-D (3.0 μM) + Napthalene acetic acid (NAA, 2.0 mg l^-1) + Kin (0.5 mg l^-1), also supplemented with casein (50 mg l^-1). This combination for reculture resulted in vigorous callus growth on fresh weight basis. Best somatic ernbryogenesis was achieved when callus tissue so obtained was further recultured in MS + NAA (1.0 mg l^-1) + Kin (0.5 mg l^-1) + Gibberelic acid (GA3 1.0 mg l^-1) + L- Ascorbic and (Asc, 50 mg l^-1) alongwith glycine (1.0 mg l^-1) + thiamine (Thia, 1.0 mg l^-1) as adjuvants. The pH of such culture media was maintained at 5.7, incubated under a 16/8-hr light/dark cycle at 25°±1°C in the culture room. This protocol resulted in 80 per cent somatic embryogenesis out of which about 20 per cent yielded regenerants. The plantlets were carefully transferred to half-strength MS medium for further growth and hardening.

Keywords

Carica papaya Callus, Somatic Embryogenesis, Regeneration, Tissue Culture.

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Ajay Sharma ¹, P. N. Mathur ¹, G. Rajamani ¹, A. Joshi ¹

Affiliations
1 Department of Molecular Biology and Biotechnology, Rajasthan College of Agriculture Maharana Pratap University of Agriculture and Technology, Udaipur - 313001(Rajasthan), IN

Abstract

Cotyledonary explants from 4 week-old aseptic seedlings of Capsicum fruitescens cv. California Wonder were cultured on MS medium supplemented with sucrose (5%), agar (0.8%) and 2,4-D (1 mg l^-1) pH 5.7. One month old callus was subcultured on the same medium devoid of 2,4-D but with salicylic acid (0.5 to 2.0 mM) to study the role of Salicylic acid in triggering defense responses. However, the best response for salicylic acid induced plantlet regeneration was obtained at 0.5 mM concentration. Kinetin (0.5 to 5.0 mg l^-1) or Gibberellic Acid (each 0.5 to 5.0 mg l^-1) failed to do so. The salicylic acid induced cytodifferentiation and plantlet regeneration in pepper may function through the response regulator mediated two component signaling system.

Keywords

Salicylic Acid, Regeneration, Pepper.

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S. Chakraborty ¹, J. Gowrishankar ², A. Joshi ³, P. Kannan ⁴, R. K. Kohli ⁴, S. C. Lakhotia ⁵, G. Misra ⁶, C. M. Nautiyal ⁷, K. Ramasubramanian ⁸, N. Sathyamurthy ³, A. K. Singhvi ⁹

Affiliations
1 National Institute of Plant Genome Research, New Delhi, IN
2 Indian Institute of Science Education and Research Mohali, IN
3 Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru, IN
4 Central University of Punjab, Bathinda, IN
5 Banaras Hindu University, Varanasi, IN
6 Indian Institute of Science, Bengaluru, IN
7 Indira Nagar, New Delhi, IN
8 Indian Institute of Technology, Mumbai, IN
9 Physical Research Laboratory, Ahmedabad, IN

Abstract

The outcome of deliberation on various aspects of publication and free access to scientific literature by a panel of nominated fellows from three science academies, viz. Indian National Science Academy, Indian Academy of Sciences, The National Academy of Sciences India, and expert invitees are presented.

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