Refine your search
Co-Authors
Journals
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Jaswanth, A.
- Control of Urinary Risk Factors of Stones by Padina boergesenii (Allander and Kraft), a Brown Algae in Experimental hyperoxaluria
Abstract Views :477 |
PDF Views:417
Authors
Source
Journal of Natural Remedies, Vol 3, No 2 (2003), Pagination: 189-194Abstract
Objective: In view of the continued screening of seaweeds of the Gulf of Mannar for biological activity Padina boergesenii, the most common species along the Mandapam coast was identified to study the various biological effects. Padina spp, exhibits diuretic effect hence, the antiurolithiatic effect of Padina boergesenii was tested in hyperoxaluric male albino rats. Methodology: Urolithiasis was induced in rats by feeding 3% glycolic acid along with pyridoxine deficient diet. The effect of the seaweed extract (ethanolic) at different doses was determined by comparing with the controls. Results: The ethanolic extract of Padina boergesenii at a dose of (150 & 200mg /kg p.o) significantly reduced the calcium excretion to normal level and significantly decreased oxalate excretion, thus reducing the risk of calcium oxalate super-saturation in urine as compared to the pyridoxine deficient control rats. The extracts also slightly elevated phosphorous, decreased uric acid and raised the magnesium excretion. Protein and creatinine elimination was effectively normalized by the extracts. Conclusion: The antiurolithiatic activity exhibited by the ethanolic extract is related to the chemical constituents in the algae which is discussed.Keywords
Padina boergesenii, Brown Algae, Urolithiatic Activity, Pyridoxine, Magnesium- Synthesis of Novel 3-[(dialkyl/aryl amino) methyl]-2-Substituted-4(3H)- Quinazolinones and Evaluation of their Anti-Inflammatory Activity
Abstract Views :202 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312, IN
2 Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312, IN
1 Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312, IN
2 Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana-502312, IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 2 (2017), Pagination: 60-62Abstract
Literature survey reveals that in recent years several Quinazolinone derivatives have been synthesized and reported to possess varied biological and pharmacological properties. They are found to be useful as antibacterial, analgesic, anti-inflammatory, antifungal, anticonvulsant and anticancer agents. A new series of 3- [(di alkyl amino) methyl]-2-substituted-4(3H)-Quinazolinones were synthesized by the reaction of a mixture of 2-substituted-4(3H)-Quinazolinone, formaldehyde and dialkyl or diaryl amine by mannich reaction. The chemical structures of the synthesized compounds were confirmed by IR, mass spectral and C, H, N analysis techniques. The synthesized compounds were screened for anti-inflammatory activity by the carrageenan induced rat hind paw edema method. The synthesized compounds were significantly showed their antiinflammatory activity that of standard.Keywords
Quinazolinone, Isomer, Analgesic, Anti-Inflammatory, Carrageenan.- Validated RP-HPLC Method for the Simultaneous Estimation of Simvastatin and Niacin
Abstract Views :181 |
PDF Views:3
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Procadence Institute of Pharmaceutical Sciences, Rimmanaguda, Gajwel, Medak (Dt)-502312, Telangana, IN
2 Department of Pharmaceutical Analysis, Procadence Institute of Pharmaceutical Sciences, Rimmanaguda, Gajwel, Medak (Dt)-502312, Telangana, IN
3 Department of Pharmacology, Procadence Institute of Pharmaceutical Sciences, Rimmanaguda, Gajwel, Medak (Dt)-502312, Telangana, IN
1 Department of Pharmaceutical Chemistry, Procadence Institute of Pharmaceutical Sciences, Rimmanaguda, Gajwel, Medak (Dt)-502312, Telangana, IN
2 Department of Pharmaceutical Analysis, Procadence Institute of Pharmaceutical Sciences, Rimmanaguda, Gajwel, Medak (Dt)-502312, Telangana, IN
3 Department of Pharmacology, Procadence Institute of Pharmaceutical Sciences, Rimmanaguda, Gajwel, Medak (Dt)-502312, Telangana, IN
Source
Asian Journal of Research in Chemistry, Vol 9, No 2 (2016), Pagination: 62-66Abstract
A simple, accurate, precise, rapid and sensitive reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the estimation of Simvastatin and Niacin in Pure and Tablet dosage forms. Inertsil ODS, RP-18 Column (250×4.6 mm ID, 5μ) was used with a mobile phase containing a mixture of Phosphate buffer pH 2.5, Methanol and Acetonitrile in the ratio of 45:20:35. The procedure was carried out at pH-3.5. The compounds were eluted at a flow rate of 1.0 ml/min. results were determined at 220 nm with fixed wavelength PDA detector. The linearity for Niacin was found between 75-175 μg/ml and between 3-7 μg/ml for Simvastatin. The retention times were found as 4.747 min and 2.970 min for Niacin and Simvastatin respectively. The above method was validated in terms of System suitability, linearity, accuracy, precision, Limit of Detection (LOD), Limit of Quantification (LOQ), Robustness in accordance with ICH guidelines. The method was rapid, simple, economical and suitable for routine quality control analysis.Keywords
Simvastatin, Niacin, Method Development, Validation, RP-HPLC.- Formulation and Evaluation of Oro Dispersible Tablets of Atenolol by Sublimation Method
Abstract Views :464 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutics, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, IN
2 Department of Pharmaceutics, Talla Padmavathi College of Pharmacy, karreeemabad Bodrai (V), Warangal (D), Telangana – 506012, IN
3 Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, IN
4 Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, IN
1 Department of Pharmaceutics, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, IN
2 Department of Pharmaceutics, Talla Padmavathi College of Pharmacy, karreeemabad Bodrai (V), Warangal (D), Telangana – 506012, IN
3 Department of Pharmaceutical Chemistry, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, IN
4 Department of Pharmacology, Surabhi Dayakar Rao College of Pharmacy, Rimmanaguda (V), Gajwel (M), Siddipet (D), Telangana – 502312, IN
Source
Asian Journal of Pharmacy and Technology, Vol 8, No 1 (2018), Pagination: 1-7Abstract
The present study aims to formulate and evaluate oro dispersible tablets of Atenolol, a drug that is used for the treatment of chest pain (angina) was prepared by using sublimation method and also optimize the best formulation. The study involved different excipients which were tested for their compatibility with Atenolol by the FT-IR studies. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Atenolol which were used for the preparation of Atenolol oral disintegrating tablets. Oral disintegrating tablets of Atenolol were prepared by direct compression method by the addition of subliming agents. Twelve batches (H1-H12) of oral disintegrating tablets of Atenolol were prepared by using Subliming agents like Ammonium Carbonate, Camphor, Thymol and Menthol in variable concentrations along with other excipients for the development of optimized formulation. All the formulations were subjected to evaluation studies of weight variation, hardness, friability, drug content, Wetting time, in-vitro disintegration, in vitro-dissolution studies and are found to be within the limits.Keywords
Oro Dispersible Tablet (ODT), Atenolol, Direct Compression, Sublimation Method, Anti Angina Activity.References
- Rangasamy Manivannan. Oral disintegrating tablets: A future Compaction Publication. International Journal of Pharmaceutical Research and Development 2009; 1: 1-10.
- Ibrahim HK, El-Setouhy DA. Valsartan orodispersible tablets: formulation, in vitro/in vivo characterization. AAPS PharmSciTech 2010;11: 189-96.
- Revathi S, Moulali SK, Dhanaraju MD. Formulation and evaluation of orodispersible valsartan tablets. Pharm Lett. 2015; 7: 315-24.
- Rewar S, Singh C, Bansal B, Pareek R, Sharma A. Oral dispersible tablets: An overview; development, technologies and evaluation. Int J Res Dev Pharm Life Sci. 2014; 3: 1223-35.
- Deshpande K, Ganesh N. Orodispersible tablets: an overview of formulation and technology. Int J Pharma Biol Sci. 2011; 2: 72634.
- L Lachman, HA Liberman, Joseph L Kani G. The Theory and Practice of Industrial Pharmacy. Varghese publishing house. Bombay. 1990; 3rd Edition: p. 315-317.
- Patel B, Patel JK, Rajput G, Thakor R. Formulation and evaluation of tablets of cinnarizine. Journal of pharmacy research. 2009; 2(3):510-13.
- L Lachman, HA Liberman, Joseph L Kani G. The Theory and Practice of Industrial Pharmacy. Verghese Publication House. Bombay. 1990; 3rd Edition: p. 171-193.
- Jeevanandham S , Dhachinamoorthi D, Chandrashekhar KB, Muthukumaran M, Sriram N. Formulation and evaluation of naproxen sodium orodispersible tablets- A sublimation technique. Asian journal of pharmaceutics. 2010; 4(1):48-51.