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Harani, A.
- Inhibitory Effects of Ethanolic Extract of Physalis minima on Amylase, Lipase and Alpha Glucosidase
Abstract Views :311 |
PDF Views:0
Authors
S. N. Raju
1,
D. Sathis Kumar
2,
Otilia Banji
1,
David Banji
1,
P. Yogeswaran
1,
D. Narender Prasad
1,
A. Harani
1
Affiliations
1 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh-508 001, IN
2 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh-508 001, IN
1 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh-508 001, IN
2 Nalanda College of Pharmacy, Nalgonda, Andhra Pradesh-508 001, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 2 (2010), Pagination: 159-162Abstract
The aim of the present study was to assess the effects of ethanolic extract of Physalis minima on the amylase, lipase and alpha glucosidase activity in vitro. Powder of whole plant of Physalis minima was extracted in ethanol and the extract was assayed for the measurement of inhibitory effects on activities of enzymes. The extracts rich in bioactive phytochemicals showed inhibitory activity on the amylase, lipase and alpha glucosidase, thus suggesting that extract might be useful in the treatment to limit dietary fat and glucose absorption and the accumulation of fat in adipose tissue. The extracts of Physalis minima may be safe, natural and cost effective for reducing fat and glucose absorption.Keywords
Physalis minima, Amylase, Lipase, Alpha Glucosidase.
- Molecular Interaction Studies of Phosphatidylcholine As Drug Delivery Substrate For Asenapine Maleate
Abstract Views :541 |
PDF Views:195
Authors
A. Harani
1,
J. VijayaRatnam
1,
B. Dipankar
2,
D. Sathis Kumar
3,
M. Bhagya Lalitha
3,
S. P. N. Kumar
3
Affiliations
1 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, IN
2 Certum Analytics, Certum Ventures Private Limited, Hyderabad - 500 023, IN
3 Aditya Pharmacy College, Surampalem - 533 437, IN
1 University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, IN
2 Certum Analytics, Certum Ventures Private Limited, Hyderabad - 500 023, IN
3 Aditya Pharmacy College, Surampalem - 533 437, IN
Source
Current Science, Vol 115, No 3 (2018), Pagination: 499-504Abstract
Phospholipid complexes have become promising delivery systems for delivery of drugs with poor bioavailability like asenapine maleate. To improve the bioavailability of asenapine maleate, phospholipid complex was chosen for the drug with Phospholipon 90 G (phosphatidylcholine). The automated molecular docking calculation for asenapine and maleate individually with phospholipid was performed by AutoGrid 4.2.6, a docking program. The van der Waals hydrogen bond, electrostatic potential energy and desolvation free energy grid maps were calculated by AutoDock parameter set- and distance-dependent dielectric functions respectively. The change in free energy was specifically seen for the complex between asenapine and phospholipid which exhibited least binding docking energy of –3.86 kcal/mol among the summary of 25 poses. Finally, molecular docking studies confirmed that the asenapine is able to make a complex with phosphatidylcholine, plausibly on account of its structural similarity with phospholipid in its physiochemical properties.Keywords
Asenapine, Binding Docking Energy, Maleate, Phosphatidylcholine.Full Text
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