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Rajiv Kukkar ¹, Mona R. Kukkar ², S. H. Shukla ³, A. K. Saluja ²

Affiliations
1 Department of Pharmacognosy, Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, P.O. Box 53, Beyond G .I .D .C, Phase IV, PO. Vitthal Udyognagar-388 121, Gujarat, IN
2 A. R. College of Pharmacy, Vallabh Vidyanagar, Gujarat, IN
3 Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Gujarat, IN

Abstract

The present study deals with the preparation of Kajjali using equal proportions of mercury and sulphur. Prior to preparation, mercury and sulphur were purified according to procedure mentioned in Ayurvedic literature. The final product, Kajjali, was analysed for various parameters like Physical characterization, Elemental analysis by Inductive Coupled Plasma (ICP), Energy Dispersive X-ray Analysis (EDAX), Particle Size distribution and Determination of Particle shape by Particle size analyzer. Some of the results obtained can be used for standardization of Kajjali.

Keywords

Kajjali, Analysis, Inductive Coupled Plasma, Energy Dispersive X-Ray Analysis.

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U. D. Shah ¹, M. B. Shah ², A. K. Saluja ³

Affiliations
1 Department of Pharmacognosy, APMC College of Pharmaceutical Education Research, Himatnagar, IN
2 Dept. of Pharmacognosy, L. M. College of Pharmacy, Ahmedabad, IN
3 Dept. of Pharmacognosy, A. R. College Pharmacy, Vallabh Vidyanagar, IN

Abstract

Fresh stembark of Albizzia lebbeck was studied for macro and microscopical characters. Betulinic acid was isolated and identified by M. P., co-chromatography with reference standard and IR spectral characteristics. HPTLC method was developed for quantification of betulinic acid using precoated silica gel plates as a stationary phase, Toluene: Acetone: Acetic acid (100:1:0.1) as a mobile phase and anisaldehyde sulphuric acid as a spray reagent. The bark is rough as longitudinal fissures and transverse cracks are present. TS of bark shows rhytidoma as a major portion followed by stone cell bands and secondary phloem with groups of phloem fibres, with starch and prisms of calcium oxalate being found in all the tissues. Saponins, tannins, triterpenoids and flavanoids were found be the major components of the bark. HPTLC method was developed for quantification of betulinic acid by scanning the plates at 523nm. The quality parameters and HPTLC method developed would serve as useful tools in standardization of Albizzia lebbeck.

Keywords

Albizzia lebbeck, HPTLC, Quality Parameters, Betulinic Acid.

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Nitin Dubey ¹, Nidhi Dubey ², R. S. Mehta ³, A. K. Saluja ³, D. K. Jain ¹

Affiliations
1 College of Pharmacy, IPS Academy, Indore [M.P], IN
2 School of Pharmacy, Devi Ahilya University, Indore [M.P], IN
3 A R College of Pharmacy, Vallabh Vidyanagar [Gujarat], IN

Abstract

Kushta-e-gaodanti was prepared as per the method mentioned in Unani formulary. The raw materials, intermediates obtained during the preparation of kushta and the final product were characterized using modern analytical techniques like Fourier transform infra-red spectroscopy (FTIR). X-ray powder diffraction (XRPD) and thermo gravimetric analysis (TGA). The study shows that the mineral Gaodanti (calcium sulphate dihydrate) is converted into calcium sulphate hemi hydrate on first calcination in earthen pot sealed with the process gil-e-hikmat. Further on calcination this intermediate is transformed to kushta-e-gaodanti which is orthorhombic α-calcium sulphate anhydride. Kushta-e-gaodanti is a fine powder with particle size 7-8 micrometer, calcium content 29.32%, bulk density 0.928, tapped density 1.268, angle of repose 36.67° and the value of Carr’s index is 47.08. Loss on drying at 110°C and loss on ignition was not more than 0.5 %w/w and 0.05% w/w respectively. Microbial load of the preparation was found negative for the presence of Escherichia coli, Salmonella species and Staphylococcus aureus. Total aerobic count was under acceptance limit. Trace element analysis of bhasma by ICP-OES revealed the presence of some other important metals like arsenic, lead, chromium, cadmium, mercury, tin under acceptable limits at prescribed dose.

Keywords

FTIR, Calcination, Unani Traditional Medicine.

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