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Nadiminti Satish Reddy ¹, Vidyasabbani ¹, B. Pravanthi ¹, B. Vijaya Laxmi ¹, B. Harika ¹

Affiliations
1 Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, IN

Abstract

Objective: The main objective of this work is to evaluate the invivo antidiabetic activity of ethanolic extract of Rumex vesicarius in the streptozotocin induced diabetic rats.

Methods: Single intraperitoneal injection (i.p.) of streptozotocin (60 mg/kg body weight) was used for induction of diabetes in albino rats . The induction of diabetes was confirmed after 3 days of streptozotocin injection and rats with fasting blood glucose levels were greater than 200 mg/dl and were considered to be diabetic used in the experiment. Rumex vesicarius at a once daily dose of 100 mg/kg, 200 mg/kg and 400 mg/kg along with Glibenclamide 10 mg/kg was also given for 1 week. On the last day, the blood was collected from all group of rats which have fasted overnight by puncturing the retro-orbit of the eye under mild ether anesthetic condition.

Results: The statistical data indicated that the different doses of Rumex vesicarius significantly decreases the level of blood glucose in streptozotocin induced rats. This result indicated that Rumex vesicarius can protect pancreatic βcells from streptozotocin induced damage which is confirmed by the results of histopathological examination of pancreas.

Conclusion: Our investigation has clearly indicated that ethanolic extract of Rumex vesicarius showed antihyperglycemic activity due to its possible systemic effect involving in pancreatic mechanism.

Keywords

Rumex vesicarius, Diabetes, Histopathology, Pancreas, Glibenclamide.

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Nadiminti Satish Reddy ¹, D. Santhosha ¹, Vidyasabbani ¹, P. Vishwanath Reddy ¹, Venu ¹

Affiliations
1 Department of Pharmacology, Vishnu Institute of Pharmaceutical Education and Research, Vishnupur, Narsapur, Medak, Telangana, IN

Abstract

The methanolic extract leaves of Cleome gynandra (Family Capparidaceae) was selected to evaluate the antidiarrhoeal activity against castor oil and magnesium sulphate induced diarrhoea in wistar albino rats. The present study was performed at three different doses of 100 mg/kg, 200mg/kg and 400mg/kg methanolic extract of plant. The Methanolic plant extracts shows more effective antidiarrhoeal activity against castor-oil induced diarrhea compared to magnesium sulphate induced diarrhoea in a dose dependent manner. From the results we conclude that methanolic leaf extracts of Cleome gynandra had reported antidiarrhoeal activity similar to standard drug loperamaide at dose of 3 mg/kg.

Keywords

Cleome gynandra, Antidiarrhoeal Activity, Loperamide, Castor Oil, Magnesium Sulphate.

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