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Authors
Affiliations
1 Assist Prof. Dr., College of Medicine, University of Baghdad, IQ
2 Prof. Dr., College of Medicine, University of Baghdad, IQ
3 Lecturer Dr., University of Al-Hilla Islamic, IQ
4 Prof. Dr. College of Science, University of Babylon, IQ
Source
Indian Journal of Public Health Research & Development, Vol 11, No 2 (2020), Pagination: 2380-2385
Abstract
Background: A lifelong persistence of latent human cytomegalovirus (hCMV) infection may result and/or associated with Hodgkin’s lymphoma (HL). The B-cell lymphoma-2 (BCL2) is an anti-apoptotic molecule expressed in non-neoplastic lymphoid tissue (hyperplastic lymph node) while down-regulated in normal germinal center B cells. Objective: Is to analyze the concordant impact of BCL2 expression and hCMV infection on tissues from a group of patients with Hodgkin’s lymphoma.
Patients and Method: Eighty formalin-fixed, paraffin-embedded lymph node tissue-biopsies enrolled in this study; 40 from HLand 40 with unremarkable pathological changes. Detection of hCMV was done by chromogenic in situ hybridization (CISH) technique while immunohistochemistry (IHC) was used for the BCL2 protein expression.
Results: In HL, the hCMV-positiveCISH and the BCL2-positive IHC reactions were detected in 35% and 42.5% of tissues, respectively. The correlation between hCMV and BCL2 was highly significant (P = 0.002).
Conclusions: The significant co-expression of BCL2 and hCMV genes in HL tissues could point for their possible role in either lymph node pathogenesis or carcinogenesis.
Keywords
hCMV, Hodgkin’s Lymphoma, BCL2, CISH, IHC.
