Indian Journal of Public Health Research & Development

A. Julius ¹, K. Renugadevi ², S. Bhuminathan ³, S. Raghavendra Jayesh ⁴, Shobakishore ⁵

Affiliations
1 Department of Biochemistry, Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, IN
2 Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College,Venkatsennagar, IN
3 Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai,, IN
4 Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, IN
5 Department of Pathology, Sree Balaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai, IN

Abstract

Diabetes and aging are associated with reduced vascular endothelial function, 20 controls and 20 subjects with type 2 diabetes age 40 participated, a series of experiments were conducted to examine the interrelationship between age, Type 2 Diabetes Mellitus and endothelial renal function. This complication is first manifested as an increase in UAE [microalbuminuria] which progresses to over albuminuria and then to renal failure In subjects with diabetes age < 40 were more prone to nephropathy which progress to End Stage Renal Disease [ESRD]

Keywords

Diabetes Mellitus, Aging, Type 2 Diabetes Mellitus, ESRP, Nephropathy.

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B. Julius ¹, B. Durga ², S. Bhuminathan ³, Shobakishore ⁴, V. Ankayarkanni ⁵

Affiliations
1 Department of Biochemistry, Sree Balaji Dental College & Hospital Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Chennai, IN
2 Department of biochemistry, Prince Shri Venkateshwara Arts & Science College, Venkatesen Nagar, Chennai, IN
3 Department of Pronthodontics, Sree Balaji Dental College & Hospital, Narayanapuram, Chennai, IN
4 Department of Pathology, Sree Balaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai,, IN
5 Department of Physiology, Sree Balaji Dental College, Pallikaranai, Chennai. Bharath Institute of Higher Education and Research, IN

Abstract

Today millions of people die due to cigarette smoking in the world. Smoking is the most common method of consuming tobacco. Tobacco smoking is the practice of burning tobacco & inhaling the smoke Cigarette smoking is one major consequence to develop oxidative stress will damage the lung lead to death. Cigarette contains nicotinean addictive stimulant that causes psychological and physical dependency The aim of the study is to evaluate the oxidative stress by novel non-enzymatic antioxidant between young chronic smokers and non- smokers in the fasting state.

Keywords

Alpha tocopherol, PUFA,Vitamin C,β- Carotene, ROS, Smokers and Non –Smokers.

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A. Julius ¹, K. Renugadevi ², S. Bhuminathan ³, S. Raghavendra Jayesh ³, Shobakishore ⁴

Affiliations
1 Department of Biochemistry, Sree Balaji Dental College and Hospital Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, Chennai, IN
2 Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College,Venkatsennagar, Chennai, IN
3 Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, Chennai, IN
4 Department of Pathology, Sree Balaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai, IN

Abstract

Diabetes Nephropathy is a major microvascular complication of Diabetes Mellitus and the most common cause of End Stage Renal Disease (ESRD) worldwide. Hyperglycemia, a well recognized pathogentic factor of long term complications of Diabetes Mellitus, generates ROS. This attenuates antioxidative mechanisms through glycation of the scavenging enzymes. Excess amount of ROS modulate activation of protein kinaseC, mitogin activated protien kinares and various cytokines and transcription factors which eventually cause increased expression of extracellular matrix (ECM) genes with progression of fibrosis and end stage renal disease. Therefore, this study was carried out to investigate oxidant and antioxidant status in Diabetic patients for manifesting the progression to diabetic nephropathy.

Keywords

Diabetic Nephropathy, Hyperglycemia, Reactive Oxygem Species, Extracellular Matrix, Oxidative Stress.

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A. Julius ¹, K. Renugadevi ², S. Bhuminathan ³, S. RaghavendraJayesh ³, Shobakishore ⁴

Affiliations
1 Department of Biochemistry, SreeBalaji Dental College and Hospital Bharath Institute of HigherEducation and Research, (Bharath University),Narayanapuram, Pallikaranai, Chennai, IN
2 Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College,Venkatsennagar, Chennai, IN
3 Department of Prosthodontics, SreeBalaji Dental College and Hospital, Bharath Instituteof Higher Education and Research, (Bharath University),Narayanapuram, Pallikaranai, Chennai, IN
4 Department of Pathology, SreeBalaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai, IN

Abstract

Tamm Horsfall Protein or Uromodulin is the most abundant urinary glycoprotein that has a protective function in the bladder mucosal layer. THP is also the primary constituent of renal tubular casts and THP aggregation has been implicated as a factor in the pathogenesis of acute renal failure by causing tubular obstruction. Using ELISA, the autoantibody level of Tamm Horsfall Protein in serum was determined in Hypertensive Patients and control subjects. A significant percentage of hypertensive subjectshave a greater risk of renal stone formation, with high autoantibodies level to Tamm Horsfall Protein in serum when compared to control subjects. Hence THP acts as a potential biomarker for nephrolithiasis in Hypertensive patients.

Keywords

Tamm Horsfall Protein Hypertension ELISA Autoantibody Nephrolithiasis.

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M. Vasanthi ¹, B. Nithya ¹, Krishna Prasanth ¹, S. Bhuminathan ²

Affiliations
1 MERF Institute of Speech and Hearing, Chennai, IN
2 COCPAR,Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education & Research, IN

Abstract

In India the incidence of Road Traffic accidents is reported to be 4,64,910 in 2017 among which 1,47,913 lives were dead and 4,70,975 persons were injured.Road traffic accidents result in various complications which will affect the person’s quality of life. One such complication is cognitive linguistic deficit. This case study is about a young man who has cognitive linguistic deficit which is a result of road traffic accident. The patient exhibited several complex cognitive- linguistic issues during the assessment. This includes reduced semantic memory, spared generative memory, reduced speech intelligibility, extensive surgical management and other behavioural problems. And he has speech and language difficulties such as reduced speech intelligibility, paraphasia, circumlocutions were present.

Keywords

Traumatic Brain Injury, Cognitive- Linguistic, Paraphasia, Circumlocution.

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Mazhar Ahmed Mohammed ¹, S. Bhuminathan ²

Affiliations
1 Department of Orthodontics and Dentofacial Orthopedics, Care Dental college, Guntur, Andhra Pradesh, IN
2 Sree Balaji Dental College and Hospital, BIHER, Chennai, IN

Abstract

With the increase in adult orthodontic treatment comes the need to find a reliable method for bonding orthodontic brackets onto metal or ceramic crowns and fixed partial dentures. In this study, shear bond strength and surface roughness tests by scanning electron microscope study were used to examine the effect of 5 different surface conditioning methods: 37% phosphoric acid gel, 9% Hydrofluoric acid, sandblasting + 9% Hydrofluoric acid, Sandblasting + Silane, Fine diamond bur roughening + silane for bonding metal brackets to ceramic surfaces of feldspathic porcelain. A total of 60 human maxillary premolar teeth extracted for therapeutic purposes from patients seeking orthodontic treatment were collected, and 50 ceramic crowns were fabricated onto the premolar teeth following crown preparation. 10 natural teeth were used as controls, they were acid etched in conventional manner using 37% phosphoric acid. Metal brackets were bonded using a light-curing composite. The samples were stored in distilled water at physiological temperature (37ºC) for 1 day, and thermocycled 500 times between 5°C and 55°C. Shear bond tests were performed with a universal testing device, and the results were statistically analysed. Ceramic surfaces conditioned with sand blasting followed by application of Silane produced maximum bond strength of 12.34 ± 0.95 MPa comparable or even better than the control group 11.03 ± 1.63 MPa followed by 9% Hydrofluoric acid 11.48 ± 0.98 MPa & Fine Diamond Bur roughening + Silane 9.28 ± 1.11 MPa. Ceramic surfaces conditioned with 37% Ortho Phosphoric acid produced least SBS of 5.51 ± 0.88 MPa and hence not suitable for bonding Orthodontic brackets in a clinical scenario. Statistical tests showed significant difference between and within the groups in shear bond strength and P value also was highly significant, i.e. ***p<0.001. The SEM photomicrographs of all the six different surface preparations revealed different surface morphologies & were corroborative of SBS values. Even though 9% Hydrofluoric acid and Fine diamond bur roughening produced clinically acceptable SBS values, because of their technique sensitivity and side effects, they have to be used with great care and caution. sand blasting followed by the application of Silane coupling agent was found to be the best porcelain surface conditioning method.

Keywords

Bond Strength, Metal Brackets, Ceramic Surfaces, PFM’s: Surface-conditioning, Sand Blasting.

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