A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Mahakalkar, S. M.
- The Psychomotor Effects of Levocetirizine - a Second Generation Antihistamine in Healthy Volunteers
Authors
1 Pharmacology Rajiv Gandhi Institute of Medical Sciences (RIMS) Adilabad A.P., IN
2 Pharmacology Rajiv Gandhi Institute of Medical Sciences (RIMS) Adilabad, A.P., IN
3 Pharmacology Wasantrao Naik Medical College Yeotmal, M.S., IN
4 Pharmacology Indira Gandhi Government Medical College Nagpur, M.S., IN
Source
Indian Journal of Public Health Research & Development, Vol 2, No 1 (2011), Pagination: 44-47Abstract
Background
Levocetirizine, a new second generation antihistamine which is claimed to be non-sedative in western studies is an R-enantiomer of cetirizine. In Indian context there is little literature available about its impact on psychomotor performance. That's why present study was planned to exclude the possibility of adverse effect of levocetirizine on psychomotor performance in Indian conditions.
Materials and methods
In this double blind, placebo controlled, cross over study, 24 healthy volunteers performed various objective and subjective psychometric test after single dose of levocetirizine 5 mg, chlorpheniramine 4 mg or placebo at 0hrs, 2hrs and 4 hrs intervals. The test battery included was - six digit cancellation test, digit symbol substitution test, arithmetic ability, critical flicker fusion, serial verbal learning, hand steadiness test and three different visual analogue scales.
Results
In the present study levocetirizine was statistically similar with chlorpheniramine on six digit cancellation test (p value <0.05), however it did not impair any other psychomotor performance test and was similar to placebo. Chlorpheniramine impaired performance significantly on all the objective and subjective psychomotor test at both time intervals.
Conclusion
It can be concluded that levocetirizine in 5mg dose is free from the negative effects of the previous generation of antihistamines and do not impair psychomotor performance in Indian conditions also.
Keywords
Levocetirizine, Six Digit Cancellation Test, Psychomotor Performance
References
- Murdoch, D., Goa, K.L., Keam, S.J. Desloratadine An update of its efficacy in the management of allergic disorders. Drugs 2003; 63 (19): 2051- 2077.
- Slater, J.W., Zechnich, A.D., Haxby, D.G. Second - generation antihistamines a comparative review. Drugs 1999; 57 (1): 31-47.
- Lawrence, M., Buske, D. Clinical comparison of histamine H1 - receptor antagonist drugs. J Allergy Clin Immunol 1996; 98 (6 pt 3): S 307 – S318.
- Verster, J.C., Volkerts, E.R., van Oosterwijck, A.W., Arab, M., Bijtjes, S.I., De Weert, A.M., Eijken, E.J., Verbaten, M.N. Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood. J Allergy Clin Immunol 2003 ;111(3) : 623-7.
- Tashiro, M., Mochizuki, H., Iwabuchi, K., Sakurada, Y., Itoh, M. Roles of histamine in regulation of arousal and cognition: functional neuroimaging of histamine H1 – receptor in human brain. Life Sci 2002 ; 72 : 409-414.
- Manual on Clinical Pharmacology. Workshop on clinical pharmacology, 2003. Post Grad 1nst Med Ed Res (PGIMER) Chandigarh.
- Stone, B.M. Pencil and paper tests-sensitivity to psychotropic drugs. Br J Clin Pharmacol 1984; 18 Suppl 1: 15S-20S.
- Manual Pharmatech. Techniques in pharmacology. Seth GS Med Coll and KEM Hosp Mumbai 1996.
- Marshall, S., Colon, E.A. Effects of a llergy season on mood and cognitive functions. Ann Allergy 1993; 71: 251-258.
- Aitken, R.C.B. Measurement of feelings using visual analogue scales. Proc Roy Soc Med 1969; 62: 989-993.
- Hindmarch, 1., Johnson, S., Meadows, R., Kirkaptrick, T., Shamsi, Z. The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and wheal and flare. Curr Med Res Opin 2001; 17 (4): 241 – 55.
- Gandon, J.M., Allain, H. Lack of effect of single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor function in healthy volunteers. Br J Clin Pharmacol 2002; 54: 51- 58.
- Clarke, C.H., Nicholson, A.N. Performance studies with antihistamines. Br J Clin Pharmacol 1978 ; 6 : 31-35.
- Meador, K.J., Ioring, D.W., Thompson, E.E., Thompson, W.O. Differential cognitive effects of terfenadine and chlorpheniramine. J Allergy Clin Immunol 1989; 84(3): 322-325.
- Khosla,P.P., Saha,N., Koul,A., Chakrabarti,A., Sankarnarayanan,A., Sharma,P.L. Effects of ranitidine alone and in combination with chlorpheniramine on histamine-induced wheal and flare and psychomotor performance. Indian J Physiol Pharmacol 1993; 37(2): 132-4.
- Simons, F.E., Reggin, J.D., Roberts, J.R., Simons, K.J. Benefit/risk ratio of the antihistamines (H1-receptor antagonists) terfenadine and chlorpheniramine in children. Pediatr 1994; 124(6): 979-83.