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Aggarwal, Roopak
- Giant Cell Tumor of Bone in Northern India-incidence, Clinical Presentation, Radiology, Histopathology and Treatment Approach
Authors
1 S.M.S.&R Gr. Noida, IN
2 CIO Lab, Pathology, VMMC and Safdarjung Hospital, New Delhi, IN
3 SMS & R, Gr. Noida, IN
Source
Indian Journal of Public Health Research & Development, Vol 4, No 2 (2013), Pagination: 215-220Abstract
Giant cell tumor is relatively uncommon benign locally aggressive neoplasm. and is still a challenge to the Surgeons in the developing countries due to limited diagnostic and therapeutic facilities.
Aim of study: This study was conducted to determine the clinical pattern of Giant cell tumors including their relative frequencies as per age and sex distributions, anatomical sites of occurrence, radiological features, histopathology features analysis and treatment approach in a tertiary care hospital of North India.
Materials and Method: This is a retrospective study of all the histopathologically confirmed Giant cell tumors seen at Safdarjang Hospital New Delhi and S.M.S. Greater Noida over a 9 year period. During this period total number of primary bone tumors were 1170.Out of these 128 were diagnosed as Giant Cell tumors and 108 cases were followed up and forms the basis of the study.
Results: Out of 108 patients there were 57 males and 51 females. Their ages ranging from 11 to 55 years with an average of 28 years. The most common sites of the lesions were the ends of long bones (90 cases), especially the distal femur (24 cases), proximal tibia (31 cases) and distal radius (11 cases). The histological pattern of giant cell tumor was rather uniform. The indispensable feature of giant cell tumor was, giant cell itself. Microscopic evidence of malignancy was found in one of our cases of giant cell tumour of recurred lesion.Various forms of treatment included were curettage, en- bloc resection and radiation.
Conclusion: Incidence of GCT was 9 % of all primary tumors. Microscopic evidence of malignancy was found in one of our cases of giant cell tumour of recurred lesion.Histological grading has little prognostic value. Benign histology does not necessarily relate to the clinical behavior of the tumor. Resection yielded the best result. Radiation therapy should be reserved for surgically inaccessible tumor because of high risk of recurrence and malignant transformation.
Keywords
Giant Cell Tumor, Histopathology, Multinucleated Giant Cell (MNGC)References
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- Giant Cell Tumour of Tendon Sheath: a Clinicopathological Study
Authors
1 A.I.I.M.S Patna, IN
2 SMS & R GR, Noida Uttar Pradesh, IN
Source
Indian Journal of Public Health Research & Development, Vol 4, No 3 (2013), Pagination: 302-305Abstract
Giant cell tumour of tendon sheath is second most common tumour of hand with high incidence of recurrence. It is slowly progressing benign tumour arising from synovial cells of tendon sheath. It occurs at any age with peak incidence in third to fourth decade. Trauma, inflammation, metabolic diseases and a neoplastic etiology are considered as etiological factors.
Aim of study: This study was conducted to share our experience of Clinicopathological aspects of Giant cell tumours of tendon sheath including their relative frequencies as per age and sex distributions, anatomical Sites of occurrence, Fine needle aspiration cytology findings &, histopathology features in School of Medical Science Greater Noida.
Material & Methods: This is a retrospective study of Giant cell tumour of tendon sheath which was done at School of Medical sciences & Research Gr. Noida U.P India during four years from 2008 t0 2012.P atients were examined clinically, FNAC & Biopsy were done and FNAC and histopathological features were studied .
Results: There were total 5 cases of giant cell tumour of tendon sheath. Most common site was fingers of hand. Age of patients varied from 25 yrs to 60 yrs. Duration of swelling were from 1 year to 3 years. Most of the swelling were approximately 2cms in diameter, firm and painless.
FNAC of the swellings revealed sheets and clusters of oval to spindle cells intermixed with mononuclear cells and osteoclast type of giant cells, suggestive of Giant cell tumour of tendon sheath.
Histopathological findings were characteristic of GCT-TS showing foamy histiocytes, multinucleate giant cells, fibroblast like cells and foamy histiocytes. Hemosiderin laden macrophages were seen in two cases ,one case revealed diffuse fibro histiocytic proliferation
Conclusion: Giant Cell tumour is a relatively rare soft tissue tumour of uncertain histogenesis. Clinical and pathological features identified were same as those of previous studies .The basic aim of management should be early diagnosis with meticulous and complete excision to prevent recurrence.
Keywords
GCTTS (Giant Cell Tumour of Tendon Sheath), Multinucleate Giant Cells, Foamy Histiocytes, FNAC (Fine Needle Aspiration Cytology)References
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