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Jassim, Nizar Abdulateef
- Effect of Smoking on Disease Activity and Functional Impairment in a Sample of Iraqi Patients with Ankylosing Spondylitis
Authors
1 Babylon Health Directorate, Marjan Medical City, IQ
2 Baghdad University, College of Medicine, Rheumatology Unit, IQ
Source
Indian Journal of Public Health Research & Development, Vol 11, No 2 (2020), Pagination: 2619-2624Abstract
Background:The etiology of AS is unknown, but a combination of genetic and non- genetic risk factors works in concert to produce clinical disease. Smoking has a negative impact on disease activity and functional ability in AS with more severe radiographic damage. The aim of this study is to assess the effect of smoking on AS disease indices (activity, and functional impairment).
Patients and Method: A cross sectional study was conducted on 150 AS patients. Information concerning smoking, demographic characteristics & clinical criteria data were gathered consisted of age, gender, BMI, duration of disease,Ankylosing Spondylitis Disease Activity Score (ASDAS-ESR), Bath ankylosing spondylitis disease activity index (BASDAI),Bath Ankylosing Spondylitis Functional Index (BASFI). All cases were investigated for HLA-B27 and ESR.
Results:A total of 150 patients with AS were involved in this research. The non-smokers constituted 52% of cases. Ex-smokers formed 14.7% of patients. Low grade smokers (<15 pack-year) formed 18% of patients and high grade smoker (15+ pack-year) formed 15.3% of patients. There is a positive relation and statistically significant moderately strong to strong positive linear correlation between AS disease activity, functional impairment. The mean ASDAS, BASDAI and BASFI was the lowest in non-smokers and elevate with increment in the number of cigarette smoking.
Conclusion:AS smoker cases had elevated disease activity & functional impairment.
Keywords
Smoking in Ankylosing Spondylitis, Smoking & As Disease Activity, Physical Function In Iraqi Patients.
- Pulmonary Function Test is More Restrictive in a smoker Patients with Ankylosing Spondylitis than in Non Smokers and is Associated with Impaired Spinal Mobility
Authors
1 Babylon Health Directorate, Marjan Medical City, Rheumatology Unit, IQ
2 Baghdad University of Baghdad, College of Medicine, Rheumatology Unit, IQ
Source
Indian Journal of Public Health Research & Development, Vol 11, No 2 (2020), Pagination: 2630-Abstract
Background:Ankylosing Spondylitis (AS) is a chronic, systemic, inflammatory, rheumatic disease affecting mainly the axial skeleton, with extra-skeletal manifestations, involving lung and an increased risk of cardiovascular morbidity. This research aims to assess the effect of smoking on pulmonary function test and spinal mobility.
Patients and Method:A cross sectional study was conducted on 150 AS patients. Information concerning smoking history, demographic and clinical data were collected. All patients were investigated for HLA-B27, complete blood count, chest x ray and pulmonary function test. AS metrology index (ASMI) measured depending five measurements.
Results:A total of 150 patients with AS were enrolled in this study (139 male and 11 female) with a mean age 36.7+/-8.2 years and mean duration of the disease 11.6+/-6.9 years. The mean FVC and FEV1 was highest among non-smokers and decrease increasing amount of smoking to reach its lowest mean among those with current high grade smoker but failed to reach the level of statistical significance. Smoking habit and age had a statistically significant association with mean of ASMI after adjusting for HLA-B27 status, gender, BMI and duration of the disease. Being a former smoker or low grade smoker is equally expected to increase ASMI by a mean of 0.85 compared to non-smokers.
Conclusion:Smoker AS patients had worse spinal mobility and restrictive PFT.