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This study aims to found the relationship of interleukin-4(IL-4) genetic polymorphism -590 C/Tin association of type-2 diabetes (T2D)development. (50) blood samples were collection from the patients with T2D and (30) samples from healthy group individual from Al-Diwaniyah Hospital. PCR-RFLP was carried out for detection IL-4 genetic polymorphism (-590 C/T) of T2D patients and healthy blood samples .The IL-4 gene polymorphism genotype frequencies were studied in the patients and healthy group, for the CC, CT and TT genotypes, the result revealed significant (p˂0.05) presence of these genotypes in the patients group compared with healthy group. Also found the TT genotype increased the risk more than 20% in T2D compared with healthy group 3.33%,and CT genotype increased the risk more than 57% in T2D compared with healthy group 30%,while CC was decreased the risk 26% in the T2D compared with healthy group 66.66% . Frequency of allele T increased to 46% in the T2D compared with healthy group 20%. While frequency of allele C was not show any signification. The allele C and T carriage rates were examined, and there was no significant changes in carriage rate for C alleles. However, a significant changes was noticed in carriage rate of T allele(78.7%) in the patients population compared to healthy population. Also the results revealed there were a significant (p˂0.05), effect of the sex and family history parameter on the IL-4 genetic polymorphism, the females and positive family history of disease 58% and 72% respectively were revealed more occurrence of this genotype in their samples with percentage. Our study was concluded that genotype C/T may be is risk factor in the T2D.

Keywords

Interleukin-4; Genetic Polymorphism -590 C/T; Type- 2 Diabetes; Iraq

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