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Authors
Affiliations
1 Post Graduate student, University of Baghdad-College of Education, Ibn-Al-Haitham-Chemistry Dept., IQ
2 Prof. Dr. University of Baghdad-College of Education, Ibn-Al-Haitham-Biology Dept., IQ
Source
Indian Journal of Public Health Research & Development, Vol 11, No 2 (2020), Pagination: 2428-2434
Abstract
Two series of metal complexes were prepared in this study, the first set from reaction of metal salts with Schiff base (HL1) as a primary ligand (which prepared by condensation of Benzdine, 2-hydroxynaphthaldehyed and 9-anthracen carbaldehyed in a one pot step with 1:1:1 molar ratio. The second series was synthesized by reaction of two mixed ligands [HL1] and 1,10-phenanthroline [L2] with the metal saltes in a 1:1:1 molar ratio. The Schiff base ligand and mixed ligand chelates characterization based on spectroscopic method; FTIR, UV-Vis, 1H-NMR along with elemental analysis, metal content, melting point, magnetic susceptibility and conductance measurements. The Schiff base ligand and mixed ligand complexes were found to have the general formulae [M(L1)2(H2O)2]. H2Oand [M(L1)(1,10phen)] Cl. H2O, where (M=Mn(II), Co(II), Cu(II), Ni(II), Zn(II) and Cd(II) respectively. Octahedral geometrical structures were proposed for (HL1) complexes while a tetrahedral structure was proposed for the mixed ligand complexes. The interactions of prepared compounds with DNA were investigated by gel electrophoresis and Ultra-Violet spectroscopy. The results of DNA binding and cleavage experiments displayed that some metal complexes were able to interact with DNA in intercalative mode, these results suggested the possible utilization of metal complexes for pharmaceutical applications.
Keywords
Schiff-Base Ligand, Benzdine, DNA Cleavage, DNA Interactions.
