A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Sanjeevreddy, M
- Role of Imprint Cytology in the Diagnosis of Upper Gastrointestinal Tract Lesions
Authors
1 Department of Pathology, BLDEA's Shri B M Patil Medical College and Research Centre, Bijapur, Karnataka, IN
2 Dept. of Pathology, Belgaum Institute of Medical Sciences, Belgaum, Karnataka, IN
3 Dept of Gastroenterology, BLDEA's Shri B M Patil Medical College and Research Centre, Bijapur, Karnataka, IN
4 Department of Pathology, Jawaharlal Nehru Medical College, KLE, University, Belgaum, Karnataka, IN
5 Department of Pathology, BLDEA's Shri B M Patil Medical, College and Research Centre, Bijapur, Karnataka, IN
Source
Indian Journal of Public Health Research & Development, Vol 4, No 3 (2013), Pagination: 190-195Abstract
Background: Histological study of the upper gastrointestinal (GI) endoscopic biopsies provides an accurate diagnosis of the lesions occurring in these regions. But the limitation of histology is longer time required. Study of imprint smears of endoscopic biopsies enables an immediate report.
Aim: To compare the accuracy of endoscopic biopsy imprint cytology with histology in the diagnosis of upper gastrointestinal tract lesions.
Materials and Method: A total of 77 cases were studied over a period of two years. The endoscopic biopsy tissue was first taken on a clean glass slide and rolled gently with the help of a needle to make an imprint of the tissue on the slide. These imprint smears were immediately fixed with 95% alcohol and stained with H and E and PAP stain. After the imprint smears are made the same biopsy tissue was then put in 10% formalin for routine histopathological processing. Two separate staff studied the imprint smears and histopathology slides independently and later the findings were correlated.
Results: Biopsy histology results were found to be correct in 100% cases. Imprint cytology had an overall accuracy of 97.6%, 100% and 100% for the diagnosis of malignancies of the oesophagus, stomach and duodenum respectively. One false result was obtained in oesophageal lesions. The combined diagnostic accuracy of imprint cytology and histology for all upper GI lesions was 100%.
Conclusion: Imprint cytology can serve as a useful and simple tool for an immediate and accurate diagnosis of upper GI malignancies.
Keywords
Imprint Cytology, Malignancy, Upper Gastrointestinal Tract
References
- Mysorekar VV, Dandekar CP, Satyaprakash BS, Sarkar A. Role of imprint cytology in the diagnosis of gastrointestinal tract malignancies. Indian J Pathol Microbial 2003;46(1):37-43.
- Geisinger KR, Wang HH, Ducatman BS, Teot LA. Gastrointestinal cytology. Clinics in laboratory medicine 1991;11(2):403-40.
- Geisinger KR, Stanley MW, Raab SS, Silverman JF, Abati A. Gastrointestinal system. In: Modern cytopathology 1st edn. Philadelphia: Churchill livingstone;2004. 449-50.
- Kobayashi S, Prolla JC, Winans CS, Kirsner JB. Improved endoscopic diagnosis of gastrooesophageal cancer. Combined use of direct vision brushing cytology and biopsy. JAMA 1970;212:2086-89.
- Young JA, Hughes HE, Lee FD. Evaluation of endoscopic brush and biopsy touch smear cytology and biopsy histology in the diagnosis of carcinoma of the lower oesophagus and cardia. J clin pathol 1980;33:811-14.
- Jaiswal KN, Umap PS, Jaiswal N, Shrikhande AV. Crush preparation cytology of gastrointestinal malignancies. Journal of cytology 2005;22(1): 35-38.
- Gupta SC, Bisht D, Nigam DK, Sati HC, Singh PA. Fibre-optic endoscopy, endoscopic brush and biopsy imprint cytology and bioptic histology in lesions of upper gastro-intestinal tract. Indian J Pathol Microbial 1984;27:229-40.
- Sharma P, Misra V, Singh PA, Misra SP, Gupta SC. A correlative study of histology and imprint cytology in the diagnosis of gastrointestinal tract malignancies. Indian J Pathol Microbial 1997;40:139-46.
- Young JA, Hughes HE. Three year trial of endoscopic cytology of the stomach and duodenum. Gut 1980;21:241-46.
- Gupta RK, Rogers KE. Endoscopic cytology and biopsy in the diagnosis of gastroesophageal malignancy. Acta cytologica 1983;27(1):17-22.
- Chun-Sheng Lan. Critical evaluation of the cytodiagnosis of fibrogastrorndoscopic samples obtained under direct vision. Acta cytological 1990;34(2):217-20.
- Waldron R, Kerin M, Ali A et al. Evaluation of the role of endoscopic biopsies and cytology in the detection of gastric malignancy. Br J Surg 1990;77:62-63.