Indian Journal of Public Health Research & Development

Jayamathi Govindaraj ¹, Keerthidaa Govindaraj ², S. Raghavendra Jayesh ³, Padmavathy Kesavaram ⁴, U. Vidyarekha ⁵

Affiliations
1 Professor, Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
2 MDS Department of Periodontics, Thai Mookambihai Dental College and Hospital, MGR University, Maduravoyal, IN
3 Professor, Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (BIHER) Pallikaranai, IN
4 Associate Professor, Department of Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
5 Senior Lecturer in Public Health Dentistry, Sree Balaji Dental College and Hospital, Bharath institute of Higher education and Research, Pallikaaranai, Chennai, IN

Abstract

Reactive oxygen species (ROS) were once considered to be deleterious agents, contributing to a vast range of pathologies. Both their damaging and beneficial effects are initiated when they target distinct molecules and consequently begin functioning as part of complex signal-transduction pathways. The recognition of ROS as signaling mediators has driven a wealth of research into their roles in both normal and pathophysiological states. The present review assesses the outline of current perspectives on redox-signaling mechanisms.

Keywords

Reactive Oxygen Species, Oxidative Stress, Nitric Oxide.

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Jayamathi Govindaraj ¹, Keerthidaa Govindaraj ², S. Raghavendra Jayesh ³, Padmavathy Kesavaram ⁴, U. Vidyarekha ⁵

Affiliations
1 Professor, Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
2 MDS Department of Periodontics, Thai Mookambihai Dental College and Hospital, MGR University, Maduravoyal, IN
3 Professor, Department of Prosthodontics, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, (BIHER), Pallikaranai, IN
4 Associate Professor, Department of Microbiology, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, IN
5 Senior Lecturer in Public Health Dentistry, Sree Balaji Dental College & Hospital, Bharath institute of Higher education and Research, Pallikaaranai, Chennai, IN

Abstract

Adipocytokines are mainly adipocyte-derived cytokines regulating metabolism and are key regulators of insulin resistance. Visfatin is a newly discovered adipocyte hormone with a direct relationship type 2 diabetes mellitus. Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is a protein with diverse functions. Although the first discovery of this molecule as a pre-B-cell colony-enhancing factor suggested primarily a cytokine function, its rediscovery as the key enzyme in nicotinamide adenine dinucleotide generation has considerably widened its potential biological activities. Its broad spectrum of effects is being regarded as a potential approach to prevent and treat various pathological conditions.

Keywords

Adipose Tissue, Adipokines, Quinolinc Acid, Insulin Resistance.

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